A volumetric MRI study of the hippocampus and the parahippocampal region after unilateral medial temporal lobe resection

Noulhiane, Marion; Samson, Séverine; Clemenceau, Stéphane; Dormont, Didier; Baulac, Michel; Hasboun, Dominique

doi:10.1016/j.jneumeth.2006.02.021

Cited by 37 publications

(32 citation statements)

References 68 publications

(79 reference statements)

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“…Such increases in volume suggest that contralateral compensation for iatrogenic damage may have occurred via enhanced synaptic connectivity or other processes that impact structural volumes, as documented in murine somatosensory cortex lesion studies [28]. While this post-surgical phenomenon for the hippocampus was reported in one study of epileptic patients [37], it was not observed in another [34]. The latter study also found no post-operative contralateral differences from controls in measured volumes of the temporopolar cortex and regions of the parahippocampal gyrus (perirhinal, entorhinal, and parahippocampal cortices).…”

Section: Discussionmentioning

confidence: 99%

Influences of temporal lobe epilepsy and temporal lobe resection on olfaction

et al. 2018

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Although temporal lobe epilepsy (TLE) and resection (TLR) impact olfactory eloquent brain structures, their influences on olfaction remain enigmatic. We sought to more definitively assess the influences of TLE and TLR on olfaction using three well-validated olfactory tests and measuring the tests' associations with the volume of numerous temporal lobe brain structures. The University of Pennsylvania Smell Identification Test and an odor detection threshold test were administered to 71 TLE patients and 71 age- and sex-matched controls; 69 TLE patients and controls received an odor discrimination/memory test. Fifty-seven patients and 57 controls were tested on odor identification and threshold before and after TLR; 27 patients and 27 controls were similarly tested for odor detection/discrimination. Scores were compared using analysis of variance and correlated with pre- and post-operative volumes of the target brain structures. TLE was associated with bilateral deficits in all test measures. TLR further decreased function on the side ipsilateral to resection. The hippocampus and other structures were smaller on the focus side of the TLE subjects. Although post-operative volumetric decreases were evident in most measured brain structures, modest contralateral volumetric increases were observed in some cases. No meaningful correlations were evident pre- or post-operatively between the olfactory test scores and the structural volumes. In conclusion, we demonstrate that smell dysfunction is clearly a key element of both TLE and TLR, impacting odor identification, detection, and discrimination/memory. Whether our novel finding of significant post-operative increases in the volume of brain structures contralateral to the resection side reflects plasticity and compensatory processes requires further study.

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Section: Discussionmentioning

confidence: 99%

Influences of temporal lobe epilepsy and temporal lobe resection on olfaction

et al. 2018

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“…Authors who performed MRI volumetry analysis often came to the conclusion that the amount of the resected tissues varies considerably [28,30] . Detailed volumetry of the hippocampus and of the parahippocampal region was published by Noulhiane et al [31] after ATL and AHE. Their volumetric results were similar to ours from the group of subjects treated surgically.…”

Section: Discussionmentioning

confidence: 99%

Microsurgical and Stereotactic Radiofrequency Amygdalohippocampectomy for the Treatment of Mesial Temporal Lobe Epilepsy: Different Volume Reduction, Similar Clinical Seizure Control

Malíková

Vojtěch

Procházka

et al. 2009

Stereotact Funct Neurosurg

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We compared stereotactic radiofrequency amygdalohippocampectomy (SAHE) with microsurgical amygdalohippocampectomy (AHE) in a group of 33 patients with mesial temporal lobe epilepsy in terms of hippocampal and amygdalar volume reductions and clinical outcome. In 23 subjects treated by SAHE, the hippocampal volume decreased by 58.0% (20.0; median, quartile range), with p = 10^–4, and the amygdalar volume decreased by 55.2% (23.8), with p = 10^–4. Two years after SAHE, 74% of patients were classified as class I, 22% as class II and 4% as class III. In 10 subjects treated by AHE, 83.5% (11.2) of the hippocampal and 53.1% (53.9) of the amygdalar volumes were removed (p = 0.05 and p = 0.005, respectively). Two years after the operation, 50% of the subjects were classified as class I, 30% as class II and 10% as class III and IV. To conclude, SAHE leads to a similar reduction of the amygdalar volume but to a significantly lower reduction of the hippocampal volume than AHE. The clinical outcome of SAHE is comparable with that of AHE.

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“…Eight ROIs were manually delineated in the MTL on both sides of each subject, as described in previous studies (Noulhiane et al, 2006, 2007; de Vanssay-Maigne et al, 2011): AC, hippocampus head, body, and tail, entorhinal, perirhinal, parahippocampal and temporopolar cortices. The ROI boundaries were identified using anatomical landmarks (Insausti et al, 1998; Duvernoy and Bourgouin, 1999; Pruessner et al, 2002) taking into account hippocampus development (Insausti et al, 2010).…”

Section: Methodsmentioning

confidence: 99%

Memory for fearful faces across development: specialization of amygdala nuclei and medial temporal lobe structures

Pinabiaux

Hertz-Pannier

Chiron

et al. 2013

Front. Hum. Neurosci.

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Enhanced memory for emotional faces is a significant component of adaptive social interactions, but little is known on its neural developmental correlates. We explored the role of amygdaloid complex (AC) and medial temporal lobe (MTL) in emotional memory recognition across development, by comparing fMRI activations of successful memory encoding of fearful and neutral faces in children (n = 12; 8–12 years) and adolescents (n = 12; 13–17 years). Memory for fearful faces was enhanced compared with neutral ones in adolescents, as opposed to children. In adolescents, activations associated with successful encoding of fearful faces were centered on baso-lateral AC nuclei, hippocampus, enthorhinal and parahippocampal cortices. In children, successful encoding of fearful faces relied on activations of centro-mesial AC nuclei, which was not accompanied by functional activation of MTL memory structures. Successful encoding of neutral faces depended on activations in anterior MTL region (hippocampal head and body) in adolescents, but more posterior ones (hippocampal tail and parahippocampal cortex) in children. In conclusion, two distinct functional specializations emerge from childhood to adolescence and result in the enhancement of memory for these particular stimuli: the specialization of baso-lateral AC nuclei, which is associated with the expertise in processing emotional facial expression, and which is intimately related to the specialization of MTL memory network. How the interplay between specialization of AC nuclei and of MTL memory structures is fundamental for the edification of social interactions remains to be elucidated.

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A volumetric MRI study of the hippocampus and the parahippocampal region after unilateral medial temporal lobe resection

Cited by 37 publications

References 68 publications

Influences of temporal lobe epilepsy and temporal lobe resection on olfaction

Influences of temporal lobe epilepsy and temporal lobe resection on olfaction

Microsurgical and Stereotactic Radiofrequency Amygdalohippocampectomy for the Treatment of Mesial Temporal Lobe Epilepsy: Different Volume Reduction, Similar Clinical Seizure Control

Memory for fearful faces across development: specialization of amygdala nuclei and medial temporal lobe structures

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