A volumetric MRI and magnetization transfer imaging follow-up study of patients with first-episode schizophrenia

Price, Gary; Cercignani, Mara; Bagary, M.; Barnes, Thomas R. E.; Barker, Gareth J.; Joyce, Eileen M.; Ron, María A.

doi:10.1016/j.schres.2006.06.019

Cited by 36 publications

(19 citation statements)

References 59 publications

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“…There is growing evidence for disruption of white matter integrity in the early stages of schizophrenia (Price et al, 2006, 2007; Pérez-Iglesias et al, 2010), which lends support to this possibility. The negative findings are also in keeping with our earlier studies in patient samples overlapping the one described here, which failed to demonstrate differences in cortical volume between patients and controls using surface-based morphometry (Gutiérrez-Galve et al, 2010) and only fronto-temporal white matter volume loss with no cortical changes observed when using magnetization transfer imaging or volumetric MRI (Price et al, 2006). …”

Section: Discussionsupporting

confidence: 92%

A window into the brain: An in vivo study of the retina in schizophrenia using optical coherence tomography

Chu

Kolappan

Barnes

et al. 2012

Psychiatry Research: Neuroimaging

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118

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Retinal nerve fibre layer (RNFL) thickness and macular volume (MV) can be measured in vivo using optical coherence tomography (OCT) providing a “window into the brain”. RNFL and MV are promising biomarkers in neurological diseases. This study explores the potential of RNFL and MV to detect axonal abnormalities in vivo in schizophrenia and their correlations with clinical features. OCT was performed in 49 patients (38 schizophrenia, 11 schizoaffective disorder) and 40 healthy controls matched for age and gender. Group comparisons were made between whole retina and quadrant RNFL thickness and MV using multi-level analyses. In patients, associations were sought between RNFL and MV with symptom severity (positive/negative). Patients and controls had similar whole retina RNFL thickness (p = 0.86) and MV (p = 0.64), but RNFL in the right nasal quadrant of the schizoaffective group was thinner than in the schizophrenia group (p = 0.02). In patients, positive symptom severity was associated with smaller MV (right β = − 0.54, p = 0.02; left β = − 0.49, p = 0.04). Normal MV and RNFL thickness suggests unmyelinated axons in patients with schizophrenia/schizoaffective disorder remain unaffected. Longitudinal studies using higher resolution OCT will clarify whether progressive RNFL and MV changes occur and whether they can be used as state or trait markers in schizophrenia.

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Section: Discussionsupporting

confidence: 92%

A window into the brain: An in vivo study of the retina in schizophrenia using optical coherence tomography

Chu

Kolappan

Barnes

et al. 2012

Psychiatry Research: Neuroimaging

Self Cite

118

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“…177 In the early stages of the disease, such MTR abnormalities tend to remain stable, as suggested by a recent 3.7-year follow-up study. 181 In patients with bipolar disorders, MTR analysis showed subtle abnormalities in the anterior cingulated and subgyral WM, in the absence of significant volumetric changes in these regions. 182 More recently, MTR abnormalities in several frontotemporal regions have been correlated with decline in intellectual quotient in these patients.…”

Section: Psychiatric Disordersmentioning

confidence: 99%

Magnetization Transfer Magnetic Resonance Imaging of the Brain, Spinal Cord, and Optic Nerve

Filippi

Rocca

2007

Neurotherapeutics

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Summary:Magnetic resonance imaging is highly sensitive in revealing CNS abnormalities associated with several neurological conditions, but lacks specificity for their pathological substrates. In addition, MRI does not allow evaluation of the presence and extent of damage in regions that appear normal on conventional MRI sequences and that postmortem studies have shown to be affected by pathology. Quantitative MR-based techniques with increased pathological specificity to the heterogeneous substrates of CNS pathology have the potential to overcome such limitations. Among these techniques, one of the most extensively used for the assessment of CNS disorders is magnetization transfer MRI (MT-MRI). The application of this technique for the assessment of damage in macroscopic lesions, in normal-appearing white and gray matter, and in the spinal cord and optic nerve of patients with several neurological conditions is providing important in vivo information-dramatically improving our understanding of the factors associated with the appearance of clinical symptoms and the accumulation of irreversible disability. MT-MRI also has the potential to contribute to the diagnostic evaluation of several neurological conditions and to improve our ability to monitor treatment efficacy in experimental trials.

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“…With a few exceptions, 39 studies have not detected differences over time. 8,33,35,36,40 Price and colleagues 36 used magnetization transfer imaging, an MRI technique sensitive to subtle anomalies, to longitudinally investigate progression of potential whole-brain neuropathological changes. They found no evidence of exaggerated progression in patients.…”

Section: Neuroimagingmentioning

confidence: 99%

The Longitudinal Course of Schizophrenia Across the Lifespan

Heilbronner¹,

Samara

Leucht³

et al. 2016

Harvard Review of Psychiatry

129

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A volumetric MRI and magnetization transfer imaging follow-up study of patients with first-episode schizophrenia

Cited by 36 publications

References 59 publications

A window into the brain: An in vivo study of the retina in schizophrenia using optical coherence tomography

A window into the brain: An in vivo study of the retina in schizophrenia using optical coherence tomography

Magnetization Transfer Magnetic Resonance Imaging of the Brain, Spinal Cord, and Optic Nerve

The Longitudinal Course of Schizophrenia Across the Lifespan

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