A vitellogenin chain containing a superoxide dismutase-like domain is the major component of yolk proteins in cladoceran crustacean Daphnia magna

Kato, Yasuhiko; Tokishita, Shin-ichi; Ohta, Toshihiro; Yamagata, Hideo

doi:10.1016/j.gene.2004.03.030

Cited by 66 publications

(47 citation statements)

References 31 publications

(31 reference statements)

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“…Importantly, the Vtg of decapodan Crustacea is not directly related to the Vtg genes of other taxons, as assumed by others (52)(53)(54)(55)(56)(57)(58)(59)(60), but is an apoB-like LLTP. This observation explains previous phylogenetic analyses on Vtgs only (57,62,69,70), in which decapodan Vtg failed to group with other invertebrate Vtgs. Phylogenetic analysis of the aligned vWF-D modules (in total only z100 aa alignable sequence) also supports the grouping of decapodan Vtg with insect apoLp-II/I and ARP, apart from an unresolved group of other LLTPs with a vWF-D module (data not shown), further supporting the notion that decapodan Vtg is an apoB-like LLTP.…”

Section: Three Families Of Lltpssupporting

confidence: 76%

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Molecular diversity and evolution of the large lipid transfer protein superfamily

Smolenaars

Madsen

Rodenburg

et al. 2007

Journal of Lipid Research

158

160

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Circulatory lipid transport in animals is mediated to a substantial extent by members of the large lipid transfer (LLT) protein (LLTP) superfamily. These proteins, including apolipoprotein B (apoB), bind lipids and constitute the structural basis for the assembly of lipoproteins. The current analyses of sequence data indicate that LLTPs are unique to animals and that these lipid binding proteins evolved in the earliest multicellular animals. In addition, two novel LLTPs were recognized in insects. Structural and phylogenetic analyses reveal three major families of LLTPs: the apoB-like LLTPs, the vitellogenin-like LLTPs, and the microsomal triglyceride transfer protein (MTP)-like LLTPs, or MTPs. The latter are ubiquitous, whereas the two other families are distributed differentially between animal groups. Besides similarities, remarkable variations are also found among LLTPs in their major lipid-binding sites (i.e., the LLT module as well as the predicted clusters of amphipathic secondary structure): variations such as protein modification and number, size, or occurrence of the clusters. Strikingly, comparative research has also highlighted a multitude of functions for LLTPs in addition to circulatory lipid transport. The integration of LLTP structure, function, and evolution reveals multiple adaptations, which have come about in part upon neofunctionalization of duplicated genes. Moreover, the change, exchange, and expansion of functions illustrate the opportune application of lipid-binding proteins in nature.Accordingly, comparative research exposes the structural and functional adaptations in animal lipid carriers and brings up novel possibilities for the manipulation of lipid transport.

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Section: Three Families Of Lltpssupporting

confidence: 76%

“…The Vtg from the water flea Daphnia magna is the only exception known at present, as it has a 145 aa superoxide dismutaselike domain N terminal to the LLT module (62) (Fig. 1).…”

Section: Modular Organization Of Lltpsmentioning

confidence: 99%

Molecular diversity and evolution of the large lipid transfer protein superfamily

Smolenaars

Madsen

Rodenburg

et al. 2007

Journal of Lipid Research

158

160

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“…16 In oviparous species, vitellogenins are known to be differentially regulated at the gene level under many stress circumstances, and normally undergo major PTM due to their involvement in the egg maturation process. 27 In the case of daphnids, this is also true during parthenogenetic reproduction, as the main product of DmagVTG1 is gradually cleaved during egg maturation. 27 There is no known direct association of vitellogenin expression in crustaceans to a particular stressor-type or environmental factor, in contrast to sh where it is related to oestrogenic compounds when found in males.…”

Section: Role Of Modied Proteinsmentioning

confidence: 99%

“…27 In the case of daphnids, this is also true during parthenogenetic reproduction, as the main product of DmagVTG1 is gradually cleaved during egg maturation. 27 There is no known direct association of vitellogenin expression in crustaceans to a particular stressor-type or environmental factor, in contrast to sh where it is related to oestrogenic compounds when found in males. 29 Yet work has been completed to establish vitellogenins as an easily applicable biomarker between invertebrate species, including daphnids.…”

Section: Role Of Modied Proteinsmentioning

confidence: 99%

“…32 The presence of a SOD domain may indicate a link with oxidative stress. Hannas et al 29 found that many of the stressors that upregulate DmagVTG2 are also linked to OS while Kato et al 27 showed that the SOD domains present some, although weak, SOD activity. Since oxidative stress is a likely candidate for the toxicity mechanism of AgNP, this could explain the impact of those compounds on vitellogenins.…”

confidence: 99%

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Proteomic evaluation of citrate-coated silver nanoparticles toxicity in Daphnia magna

Rainville

Carolan

Coelho

et al. 2014

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Access to the full text of the published version may require a subscription. Recent decades have seen a strong increase in the promise and uses of nanotechnology. This is correlated with their growing release in the environment and there is concern that nanomaterials may endanger ecosystems. Silver nanoparticles (AgNPs) have some of the most varied applications, making their release into the environment unavoidable. In order to assess their potential toxicity in aquatic environments, the acute toxicity of citrate-coated AgNPs to Daphnia magna was measured and compared to that of AgNO 3 . AgNPs were found to be ten times less toxic by mass than silver ions, and most of this toxicity was removed by ultracentrifuging. At the protein level, the two forms of silver had different impacts. RightsBoth increased protein thiol content, while only AgNP increased carbonyl levels. In 2DE of samples labelled for carbonyls, no feature was significantly affected by both compounds, indicating different modes of toxicity. Identified proteins showed functional overlap between the two compounds:vitellogenins (vtg) were present in most features identified, indicating their role as a general stress sensor.In addition to vtg, hemoglobin levels were increased by the AgNP exposure while 14-3-3 protein (a regulatory protein) carbonylation levels were reduced by AgNO 3 . Overall, this study confirms the previously observed lower acute toxicity of AgNPs, while demonstrating that the toxicity of both forms of silver follow somewhat different biologic pathways, potentially leading to different interactions with natural compounds or pollutants in the aquatic environment.

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The interplay between prior selection, mild intermittent exposure, and acute severe exposure in phenotypic and transcriptional response to hypoxia

Ekwudo

Malek

Anderson

et al. 2022

Ecology and Evolution

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Hypoxia has profound and diverse effects on aerobic organisms, disrupting oxidative phosphorylation and activating several protective pathways. Predictions have been made that exposure to mild intermittent hypoxia may be protective against more severe exposure and may extend lifespan. Here we report the lifespan effects of chronic, mild, intermittent hypoxia, and short‐term survival in acute severe hypoxia in four clones of Daphnia magna originating from either permanent or intermittent habitats. We test the hypothesis that acclimation to chronic mild intermittent hypoxia can extend lifespan through activation of antioxidant and stress‐tolerance pathways and increase survival in acute severe hypoxia through activation of oxygen transport and storage proteins and adjustment to carbohydrate metabolism. Unexpectedly, we show that chronic hypoxia extended the lifespan in the two clones originating from intermittent habitats but had the opposite effect in the two clones from permanent habitats, which also showed lower tolerance to acute hypoxia. Exposure to chronic hypoxia did not protect against acute hypoxia; to the contrary, Daphnia from the chronic hypoxia treatment had lower acute hypoxia tolerance than normoxic controls. Few transcripts changed their abundance in response to the chronic hypoxia treatment in any of the clones. After 12 h of acute hypoxia treatment, the transcriptional response was more pronounced, with numerous protein‐coding genes with functionality in oxygen transport, mitochondrial and respiratory metabolism, and gluconeogenesis, showing upregulation. While clones from intermittent habitats showed somewhat stronger differential expression in response to acute hypoxia than those from permanent habitats, contrary to predictions, there were no significant hypoxia‐by‐habitat of origin or chronic‐by‐acute treatment interactions. GO enrichment analysis revealed a possible hypoxia tolerance role by accelerating the molting cycle and regulating neuron survival through upregulation of cuticular proteins and neurotrophins, respectively.

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A vitellogenin chain containing a superoxide dismutase-like domain is the major component of yolk proteins in cladoceran crustacean Daphnia magna

Cited by 66 publications

References 31 publications

Molecular diversity and evolution of the large lipid transfer protein superfamily

Molecular diversity and evolution of the large lipid transfer protein superfamily

Proteomic evaluation of citrate-coated silver nanoparticles toxicity in Daphnia magna

The interplay between prior selection, mild intermittent exposure, and acute severe exposure in phenotypic and transcriptional response to hypoxia

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