A vitamin E long-chain metabolite and the inspired drug candidate α-amplexichromanol relieve asthma features in an experimental model of allergen sensitization

Cerqua, Ida; Neukirch, Konstantin; Terlizzi, Michela; Granato, Elisabetta; Caiazzo, Elisabetta; Cicala, Carla; Ialenti, Armando; Capasso, Renato; Werz, Oliver; Sorrentino, Rosalinda; Séraphin, Denis; Hélesbeux, Jean-Jacques; Cirino, Giuseppe; Koeberle, Andreas; Roviezzo, Fiorentina; Rossi, Antonietta

doi:10.1016/j.phrs.2022.106250

Cited by 28 publications

(6 citation statements)

References 41 publications

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“…Therefore, it is encouraging to note that our top candidate, alpha-tocotrienol, is supported by the existing literature. Furthermore, the positive outcomes demonstrated by long-chain metabolites in alleviating AR symptoms serve to reinforce our results [95]. In addition, it might highlight that molecular size plays a significant role in this inhibition.…”

Section: Perspectivesupporting

confidence: 82%

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Evaluation of Urtica dioica Phytochemicals against Therapeutic Targets of Allergic Rhinitis Using Computational Studies

Culhuac,

Bello

2024

Molecules

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Allergic rhinitis (AR) is a prevalent inflammatory condition affecting millions globally, with current treatments often associated with significant side effects. To seek safer and more effective alternatives, natural sources like Urtica dioica (UD) are being explored. However, UD’s mechanism of action remains unknown. Therefore, to elucidate it, we conducted an in silico evaluation of UD phytochemicals’ effects on known therapeutic targets of allergic rhinitis: histamine receptor 1 (HR1), neurokinin 1 receptor (NK1R), cysteinyl leukotriene receptor 1 (CLR1), chemoattractant receptor-homologous molecule expressed on type 2 helper T cells (CRTH2), and bradykinin receptor type 2 (BK2R). The docking analysis identified amentoflavone, alpha-tocotrienol, neoxanthin, and isorhamnetin 3-O-rutinoside as possessing a high affinity for all the receptors. Subsequently, molecular dynamics (MD) simulations were used to analyze the key interactions; the free energy of binding was calculated through Generalized Born and Surface Area Solvation (MMGBSA), and the conformational changes were evaluated. Alpha-tocotrienol exhibited a high affinity while also inducing positive conformational changes across all targets. Amentoflavone primarily affected CRTH2, neoxanthin targeted NK1R, CRTH2, and BK2R, and isorhamnetin-3-O-rutinoside acted on NK1R. These findings suggest UD’s potential to treat AR symptoms by inhibiting these targets. Notably, alpha-tocotrienol emerges as a promising multi-target inhibitor. Further in vivo and in vitro studies are needed for validation.

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Section: Perspectivesupporting

confidence: 82%

“…However, exploring beyond traditional vitamin E, long-chain metabolites have shown promise for inhibiting key aspects of allergic responses, including the Th2 immune response and mast cell activation [95]. This aligns with the desired inhibition of targets for AR.…”

Section: Perspectivementioning

confidence: 91%

Evaluation of Urtica dioica Phytochemicals against Therapeutic Targets of Allergic Rhinitis Using Computational Studies

Culhuac,

Bello

2024

Molecules

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“…Furthermore, low intake of fruits, vegetables, juices, and vitamins (A, C, and E) was linked to deficits in lung function in children [ 96 ], and an association between low serum vitamin A levels and airway obstruction has been shown in healthy adults [ 97 ]. Because antioxidant enzymes are fundamental in the defense of the airways against oxidative stress, some proposed therapeutic strategies involve the intake of micronutrients such as vitamins (A, C, and E), polyphenols, and carotenoids to help protect (asthmatic) individuals from oxidative stress and airway inflammation [ 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 ].…”

Section: Oxidative Stress and Inflammation In Asthmamentioning

confidence: 99%

Oxidative Stress and Inflammation in Acute and Chronic Lung Injuries

Bezerra

Lanzetti

Nesi³

et al. 2023

Antioxidants

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Acute and chronic lung injuries are among the leading causes of mortality worldwide. Lung injury can affect several components of the respiratory system, including the airways, parenchyma, and pulmonary vasculature. Although acute and chronic lung injuries represent an enormous economic and clinical burden, currently available therapies primarily focus on alleviating disease symptoms rather than reversing and/or preventing lung pathology. Moreover, some supportive interventions, such as oxygen and mechanical ventilation, can lead to (further) deterioration of lung function and even the development of permanent injuries. Lastly, sepsis, which can originate extrapulmonary or in the respiratory system itself, contributes to many cases of lung-associated deaths. Considering these challenges, we aim to summarize molecular and cellular mechanisms, with a particular focus on airway inflammation and oxidative stress that lead to the characteristic pathophysiology of acute and chronic lung injuries. In addition, we will highlight the limitations of current therapeutic strategies and explore new antioxidant-based drug options that could potentially be effective in managing acute and chronic lung injuries.

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“…The use of natural products against global public health problems is prominent. Among the potentials of these products, we can mention anti-inflammatory, antioxidant, anti-depressant, anti-cancer and anti-microbial properties [ 18 , 19 ]. There is a growing recognition of medicinal plants as providing practical resources for new drug molecules, especially when most common synthetic drugs fail [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Green and environmentally friendly synthesis of silver nanoparticles with antibacterial properties from some medicinal plants

Asefian,

Ghavam

2024

BMC Biotechnol

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Recently there have been a variety of methods to synthesize silver nanoparticles, among which the biosynthesis method is more noticeable due to features like being eco-friendly, simple, and cost-efficient. The present study aims for the green synthesis of silver nanoparticles from the extract of the three plants A. wilhelmsi, M. chamomilla, and C. longa; moreover, it pledges to measure the antibacterial activity against some variants causing a skin rash. The morphology and size of the synthesized silver nanoparticles were evaluated by UV.vis, XRD, SEM, and FTIR analyses. Then results showed a color alteration from light yellow to dark brown and the formation of silver nanoparticles. The absorption peak with the wavelength of approximately 450 nm resulting from the Spectrophotometry analysis confirmed the synthesis of silver nanoparticles. The presence of strong and wide peaks in FTIR indicated the presence of OH groups. The SEM results showed that most synthesized nanoparticles had a spherical angular structure and their size was about 10 to 20 nm. The highest inhibition power was demonstrated by silver nanoparticles synthesized from the extract combined from all three species against Gram-positive bacteria Staphylococcus aureus and Staphylococcus epidermidis (23 mm) which had a performance far more powerful than the extract. Thus, it can be understood that the nanoparticles synthesized from these three species can act as potential environment-friendly alternatives to inhibit some variations causing skin disorders; an issue that calls for further clinical studies.

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A vitamin E long-chain metabolite and the inspired drug candidate α-amplexichromanol relieve asthma features in an experimental model of allergen sensitization

Cited by 28 publications

References 41 publications

Evaluation of Urtica dioica Phytochemicals against Therapeutic Targets of Allergic Rhinitis Using Computational Studies

Evaluation of Urtica dioica Phytochemicals against Therapeutic Targets of Allergic Rhinitis Using Computational Studies

Oxidative Stress and Inflammation in Acute and Chronic Lung Injuries

Green and environmentally friendly synthesis of silver nanoparticles with antibacterial properties from some medicinal plants

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