A visual lamina in the medulla oblongata of the frog, Rana pipiens

Wallace, Mark T.; Recktenwald, Eric W.; Dudkin, Elizabeth A.; Gruberg, Edward R.

doi:10.1016/j.neulet.2020.135280

Cited by 1 publication

(1 citation statement)

References 22 publications

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“…Increased sensory evoked activity between the ventroposteromedial nucleus (VPM) and S1, but not between the dorsal lateral geniculate nucleus and V1, was observed immediately after simultaneous visual and somatosensory stimuli (32–34). Neurons responding to stimuli of different modalities were also identified in the medulla oblongata (35) and the thalamic reticular nucleus (36), both structures in close relationship with dorsal thalamic nuclei and thalamocortical circuits.…”

Section: Discussionmentioning

confidence: 99%

Bimodal sensory integration in migraine: A study of the effect of visual stimulation on somatosensory evoked cortical responses

et al. 2022

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Background Merging of sensory information is a crucial process for adapting the behaviour to the environment in all species. It is not known if this multisensory integration might be dysfunctioning interictally in migraine without aura, where sensory stimuli of various modalities are processed abnormally when delivered separately. To investigate this question, we compared the effects of a concomitant visual stimulation on conventional low-frequency somatosensory evoked potentials and embedded high-frequency oscillations between migraine patients and healthy volunteers. Methods We recorded somatosensory evoked potentials in 19 healthy volunteers and in 19 interictal migraine without aura patients before, during, and 5 min after (T2) simultaneous synchronous pattern-reversal visual stimulation. At each time point, we measured amplitude and habituation of the N20-P25 low-frequency-somatosensory evoked potentials component and maximal peak-to-peak amplitude of early and late bursts of high-frequency oscillations. Results In healthy volunteers, the bimodal stimulation significantly reduced low-frequency-somatosensory evoked potentials habituation and tended to reduce early high-frequency oscillations that reflect thalamocortical activity. By contrast, in migraine without aura patients, bimodal stimulation significantly increased low-frequency-somatosensory evoked potentials habituation and early high-frequency oscillations. At T2, all visual stimulation-induced changes of somatosensory processing had vanished. Conclusion These results suggest a malfunctioning multisensory integration process, which could be favoured by an abnormal excitability level of thalamo-cortical loops.

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