A viscous lidocaine mouthwash is no better than placebo for improving oral intake in children with painful mouth ulcers

Descroix, Vianney; Coudert, Amélie E.

doi:10.1136/ebmed-2014-110002

Cited by 1 publication

(1 citation statement)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The pain is mainly stimulated by inflammatory mediators such as prostaglandins, 5-hydroxytryptamine and bradykinin secreted by inflammatory cells [ 8 ]. At present, a combination of treatments, such as local rinses with 2% viscous lidocaine solution, mouthwash preparations and other systemic analgesics are used to control pain [ 9 ]. However, most commercially available mouthwashes contain alcohol and other ingredients, which sensitize the lesion and make patients uncomfortable.…”

Section: Introductionmentioning

confidence: 99%

Nattokinase crude extract enhances oral mucositis healing

et al. 2021

View full text Add to dashboard Cite

Background Nattokinase (NK) is a promising alternative in the prevention and treatment of cardiovascular diseases due to its potent fibrinolytic activity. In this study, we investigated the effect of crude nattokinase extract on the healing of acetic acid-induced oral mucositis in mice. Methods Bacillus subtilis culture media (BSCM) was isolated into the supernatant, named nattokinase crude extract (NCE), and the pellet was named Bacillus subtilis mass (BSM). An oral mucositis model was established in mice by applying 50% glacial acetic acid to the buccal mucosa. According to the treatment conditions, the mice were divided into BSCM, NCE, BSM and phosphate buffered saline (PBS) groups. The weight of the mice, oral mucositis healing score and histopathological examination were used to evaluate the treatment. Results Fibrinolytic activities of BSCM, NCE and BSM were approximately 8069, 10,800 and 80 U/ml, respectively. The weight gain of mice in the NCE group was significantly different from the PBS group after three days’ treatment (p < 0.05). The oral mucositis score of NCE group was significantly higher than other groups (p < 0.05). The differences in histopathology scores between the NCE and other groups were statistically significant (p < 0.01). Conclusions NCE could possess remarkable potential to reduce pain and promote oral mucositis healing with minimal safety concerns. In this study, we first report that NCE from the supernatant of Bacillus subtilis can promote the healing of oral mucositis, which extends the application scope of NK.

show abstract

Section: Introductionmentioning

confidence: 99%