A visco-poroelastic model of functional adaptation in bones reconstructed with bio-resorbable materials

Giorgio, Ivan; Andreaus, Ugo; Scerrato, Daria; Dell’Isola, Francesco

doi:10.1007/s10237-016-0765-6

Cited by 102 publications

(75 citation statements)

References 121 publications

(113 reference statements)

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“…In the fields of biomechanics, FE analysis-based bone strength assessment, 56,57 age-related (or drug-related) bone remodeling, 50,54,55,58,59 and bone reconstruction with bioresorbable material [60][61][62] have been recently developed and attempted to investigate bone microstructure for various purposes. However, due to a lack of in vivo HR imaging techniques, these methods have struggled for further clinical applications.…”

Section: Discussionmentioning

confidence: 99%

Computational study of estimating 3D trabecular bone microstructure for the volume of interest from CT scan data

Kim

Nam

Jang

2018

Numer Methods Biomed Eng

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Inspired by the self-optimizing capabilities of bone, a new concept of bone microstructure reconstruction has been recently introduced by using 2D synthetic skeletal images. As a preliminary clinical study, this paper proposes a topology optimization-based method that can estimate 3D trabecular bone microstructure for the volume of interest (VOI) from 3D computed tomography (CT) scan data with enhanced computational efficiency and phenomenological accuracy. For this purpose, a localized finite element (FE) model is constructed by segmenting a target bone from CT scan data and determining the physiological local loads for the VOI. Then, topology optimization is conducted with multiresolution bone mineral density (BMD) deviation constraints to preserve the patient-specific spatial bone distribution obtained from the CT scan data. For the first time, to our knowledge, this study has demonstrated that 60-μm resolution trabecular bone images can be reconstructed from 600-μm resolution CT scan data (a 62-year-old woman with no metabolic bone disorder) for the 4 VOIs in the proximal femur. The reconstructed trabecular bone includes the characteristic trabecular patterns and has morphometric indices that are in good agreement with the anatomical data in the literature. As for computational efficiency, the localization for the VOI reduces the number of FEs by 99%, compared with that of the full FE model. Compared with the previous single-resolution BMD deviation constraint, the proposed multiresolution BMD deviation constraints enable at least 65% and 47% reductions in the number of iterations and computing time, respectively. These results demonstrate the clinical feasibility and potential of the proposed method.

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Section: Discussionmentioning

confidence: 99%

Computational study of estimating 3D trabecular bone microstructure for the volume of interest from CT scan data

Kim

Nam

Jang

2018

Numer Methods Biomed Eng

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“…These, and many others, are the object of a next paper, together with a generalization in 3D. In order to meet the richness of behaviour of different materials, including potentially complex biological tissues [66][67][68][69][70][71], some other interesting behaviours are under study.…”

Section: Discussionmentioning

confidence: 99%

Position-based dynamic of a particle system: a configurable algorithm to describe complex behaviour of continuum material starting from swarm robotics

Dell'Erba

2018

Continuum Mech. Thermodyn.

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In a previous work we considered a two-dimensional lattice of particles and calculated its time evolution by using an interaction law based on the spatial position of the particles themselves. The model reproduced the behaviour of deformable bodies both according to the standard Cauchy model and second gradient theory; this success led us to use this method in more complex cases. This work is intended as the natural evolution of the previous one in which we shall consider both energy aspects, coherence with the principle of Saint Venant and we start to manage a more general tool that can be adapted to different physical phenomena, supporting complex effects like lateral contraction, anisotropy or elastoplasticity.

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“…Although the experimental DVC‐measured strain field contributed to an enhanced knowledge of the local mechanics in biomaterial‐mediated newly formed bone, these types of studies are limited to a single time point after implantation. Nevertheless, these findings have the potential to inform computational models of bone tissue and bioresorbable material adaptation (Lekszycki & Dell'Isola, ; Giorgio et al ., ; Giorgio et al ., ; Giorgio et al ., ), enabling predictions of the long‐term in vivo behaviour of such grafts in the repair of critical‐sized bone defects. Such models could be used for a deeper study of bone−biomaterial micromechanics, in which more physiological relevant loading and boundary conditions are considered.…”

Section: Biomechanical Xct Analysis Of Bone Regenerationmentioning

confidence: 97%

Applications of X‐ray computed tomography for the evaluation of biomaterial‐mediated bone regeneration in critical‐sized defects

Fernández

Witte²,

Tozzi

2019

Journal of Microscopy

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Bone as such displays an intrinsic regenerative potential following fracture; however, this capacity is limited with large bone defects that cannot heal spontaneously. The management of critical‐sized bone defects remains a major clinical and socioeconomic need with osteoregenerative biomaterials constantly under development aiming at promoting and enhancing bone healing. X‐ray computed tomography (XCT) has become a standard and essential tool for quantifying structure–function relationships in bone and biomaterials, facilitating the development of novel bone tissue engineering strategies. This paper presents recent advancements in XCT analysis of biomaterial‐mediated bone regeneration. As a noninvasive and nondestructive technique, XCT allows for qualitative and quantitative evaluation of three‐dimensional (3D) scaffolds and biomaterial microarchitecture, bone growth into the scaffold as well as the 3D characterisation of biomaterial degradation and bone regeneration in vitro and in vivo. Furthermore, in combination with in situ mechanical testing and digital volume correlation (DVC), XCT demonstrated its potential to better understand the bone–biomaterial interactions and local mechanics of bone regeneration during the healing process in relation to the regeneration achieved in vivo, which will likely provide valuable knowledge for the development and optimisation of novel osteoregenerative biomaterials. Lay Description Bone, being a dynamically adaptable material, displays excellent regenerative properties following fracture. However, the self‐healing capacity of bone becomes more difficult with large bone defects. Those defects are common and occur in many clinical situations; hence, biomaterials are mostly used to restore both bone structure and function in the defect site. X‐ray computed tomography (XCT) is a powerful tool to evaluate bone regeneration in critical‐sized defects after the implantation of biomaterials, allowing to an improved understanding of the regeneration process following different bone tissue engineering approaches. This paper focuses on recent advancements in XCT analysis to characterise biomaterial‐mediated bone regeneration in critical‐sized defects. XCT supports three‐dimensional (3D) analysis of biomaterials, scaffolds and regenerated bone microarchitecture, as well as bone ingrowth into the scaffold. As a nondestructive technique, XCT allows for a 3D characterisation of biomaterial degradation and bone regeneration over time. In addition, XCT combined with in situ mechanical experiments and digital volume correlation (DVC) provides a 3D evaluation and quantification of bone–biomaterial interactions and deformation mechanisms during the regeneration process. This remains essential for the development and enhancement of novel biomaterials able to produce bone that is comparable with the native tissue they aim to replace.

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A visco-poroelastic model of functional adaptation in bones reconstructed with bio-resorbable materials

Cited by 102 publications

References 121 publications

Computational study of estimating 3D trabecular bone microstructure for the volume of interest from CT scan data

Computational study of estimating 3D trabecular bone microstructure for the volume of interest from CT scan data

Position-based dynamic of a particle system: a configurable algorithm to describe complex behaviour of continuum material starting from swarm robotics

Applications of X‐ray computed tomography for the evaluation of biomaterial‐mediated bone regeneration in critical‐sized defects

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