A virtual reality counterconditioning procedure to reduce methamphetamine cue-induced craving

Wang, Yongguang; Liu, Meng-hui; Shen, Zhihua

doi:10.1016/j.jpsychires.2019.06.007

Cited by 34 publications

(34 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Visual (photographs/images and videos) ( n = 28), in vivo paraphernalia and/or simulated drug ( n = 10) and imagery cues (e.g., audiotaped scripts, recalling of last drug use) ( n = 4) were the different modalities used in all the studies to elicit responses in a cue reactivity paradigm. Several studies also designed and employed the use of a methamphetamine virtual reality (methamphetamine-VR) cue model to assess self-reported cravings and physiological changes [ 24 , 25 , 26 , 27 ]. A total of 18 studies compared effects of methamphetamine-related cues with neutral cues; some of which involved the use of cues related to nature scenes ( n = 4), beach ( n = 1), images of artifacts and normal daily actions ( n = 2), footage of tropical fish in tank/aquarium ( n = 2) or the handling of a glass of water ( n = 2) and pine cones, shells, and rocks ( n = 1).…”

Section: Resultsmentioning

confidence: 99%

“…Price et al (2010) also examined drug cue reactivity and response extinction in a laboratory setting where participants underwent a total of six cue exposure sequences, and data revealed a mean percentage change of −84.4% in craving score from Sequence 1 to end of the last cue sequence, with11 of the 20 participants reported no craving at the end of Sequence 6. Lastly, another study using virtual reality counterconditioning procedure (VRCP) and its computerized version found participants in the intervention groups to show a significantly larger decrease on methamphetamine craving and liking in a group of patients, as well as in heart rate variability on time domain and non-linear domain from baseline to follow-up assessments in a separate sample [ 26 ]. These results therefore indicated that extinction of drug-cue conditioned responding can occur in methamphetamine-using individuals, offering promise for the development of extinction- or counterconditioning-based treatment strategies.…”

Section: Resultsmentioning

confidence: 99%

“…Literature, however, suggests that extinction procedure may not be adequate in suppressing drug craving [ 62 ] and it was proposed that the affective component inherent to the drug-related cues tends to hinder the efficacy of cue exposure-based therapy in individuals with substance use disorder [ 63 ]. In this sense, the counterconditioning approach has been viewed to be a better alternative as it not only decreases the unconditioned expectancy, but also changes the emotional valence of conditioned stimuli through pairing new unconditioned stimuli with an opposite valence [ 26 ]. Previous studies have also supported counterconditioning procedures to exert a stronger suppressing effect on the relapse of memories or the cue-drug association than extinction [ 64 , 65 ].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

A Scoping Review on Cue Reactivity in Methamphetamine Use Disorder

Seow

Ong

Hombali

et al. 2020

IJERPH

View full text Add to dashboard Cite

The experience of craving via exposure to drug-related cues often leads to relapse in drug users. This study consolidated existing empirical evidences of cue reactivity to methamphetamine to provide an overview of current literature and to inform the directions for future research. The best practice methodological framework for conducting scoping review by Arkey and O’Malley was adopted. Studies that have used a cue paradigm or reported on cue reactivity in persons with a history of methamphetamine use were included. Databases such as Medline, EMBASE, PsycINFO and CINAHL were searched using key terms, in addition to citation check and hand search. The search resulted in a total of 32 original research articles published between 2006 to 2020. Three main themes with regard to cue reactivity were identified and synthesized: (1) effects of cue exposure, (2) individual factors associated with cue reactivity, and (3) strategies that modulate craving or reactivity to cues. Exposure to methamphetamine-associated cues elicits significant craving and other autonomic reactivity. Evidence suggests that drug cue reactivity is strongly associated with indices of drug use and other individual-specific factors. Future studies should focus on high quality studies to support evidence-based interventions for reducing cue reactivity and to examine cue reactivity as an outcome measure.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A Scoping Review on Cue Reactivity in Methamphetamine Use Disorder

Seow

Ong

Hombali

et al. 2020

IJERPH

View full text Add to dashboard Cite

show abstract

“…Recent research has exploited the development of high-performance virtual reality (VR) technology to increase the ecological validity of stimuli presented in studies of cue-exposure [31] , counterconditioning [32] and equilibrium training [33] . By equipping participants with headmounted VR-glasses and sufficient space to navigate within the VR-environment, a strong sense of immersion can be created, which in turn generates more realistic stimulation.…”

Section: Introductionmentioning

confidence: 99%

“…Recent research has exploited the development of high-performance virtual reality (VR) technology to increase the ecological validity of stimuli presented in studies of cue-exposure [1–3] , counterconditioning [4] , equilibrium training [5] , social gazing [6] and gambling behavior in healthy control participants [7] . Furthermore, it has been shown to increase immersion and arousal during gambling games [8] .…”

Section: Introductionmentioning

confidence: 99%

Reliability assessment of temporal discounting measures in virtual reality environments

Bruder

Scharer

Peters

2020

Preprint

View full text Add to dashboard Cite

Increased reactivity to addiction related cues (cue-reactivity) plays a critical role in the maintenance of addiction. Studies assessing cue-reactivity in gambling disorder often suffer from low ecological validity due to the usage of picture stimuli in a neutral lab environment. Here we describe a novel virtual reality (VR) set-up for the concurrent assessment of behavioral and psychophysiological cue-reactivity in gambling disorder. On two days, thirty-four healthy non-gambling participants explored two rich and navigable VR-environments (neutral: cafe vs. gambling-related: casino and sports-betting facility), while their electrodermal activity was measured using remote sensors. In addition, participants completed a temporal discounting task implemented in each VR environment. On a third day, participants performed the task in a standard lab testing context. We then used comprehensive computational modeling using both standard softmax and drift diffusion model (DDM) choice rules to assess the reliability of discounting model parameters assessed in VR. Test-retest reliability estimates were good to excellent for the discount rate log(k), whereas they were poor to moderate for additional DDM parameters. Differences in model parameters between standard lab testing and VR, reflecting reactivity to the different environments, were mostly numerically small and of inconclusive directionality. Finally, while exposure to VR generally increased tonic skin conductance, this effect was not modulated by the neutral vs. gambling-related VR-environment. Taken together this proof-of-concept study in non-gambling participants demonstrates the feasibility assessing both physiological and behavioral cue-reactivity in VR. We show that temporal discounting measures obtained in VR are reliable, suggesting that VR is a promising tool for an ecologically valid assessment of cue-reactivity in gambling disorder.

show abstract

Addressing virtual reality misclassification: A hardware‐based qualification matrix for virtual reality technology

Takac

Collett

Conduit

et al. 2021

Clin Psychology and Psychoth

View full text Add to dashboard Cite

Through its unique sensory synchronized design, virtual reality (VR) provides a convincing, user-centred experience of highly controllable scenarios. Importantly, VR is a promising modality for healthcare, where treatment efficacy has been recognized for a range of conditions. It is equally valuable across wider research disciplines. However, there is a lack of suitable criteria and consistent terminology with which to define VR technology. A considerable number of studies have misclassified VR hardware (e.g. defining laptops as VR), hindering validity and research comparisons. This review addresses these limitations and establishes a standardized VR qualification framework. As a result of a comprehensive theoretical and literature review, the hardware-based VR qualification matrix is proposed.The matrix criteria consist of (1) three-dimensional (3D) synchronized sensory stimulation; (2) degrees of freedom tracking; and (3) visual suppression of physical stimuli. To validate the model and quantify the current scale/diversity of VR misclassification, a 2019 sectional review of health-related studies was conducted.Of the 115 studies examined against standardized criteria, 35.7% utilized VR, 31.3% misclassified VR, 18.3% were considered quasi-VR, and 14.8% omitted critical specifications. The proposed model demonstrates good validity and reliability for qualifying and classifying VR.

show abstract

A virtual reality counterconditioning procedure to reduce methamphetamine cue-induced craving

Cited by 34 publications

References 42 publications

A Scoping Review on Cue Reactivity in Methamphetamine Use Disorder

A Scoping Review on Cue Reactivity in Methamphetamine Use Disorder

Reliability assessment of temporal discounting measures in virtual reality environments

Addressing virtual reality misclassification: A hardware‐based qualification matrix for virtual reality technology

Contact Info

Product

Resources

About