A Virologic Study of Chronic Bronchitis

Carilli, Albert D.; Gohd, Robert S.; Gordon, William

doi:10.1056/nejm196401162700303

Cited by 100 publications

(44 citation statements)

References 13 publications

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“…By virtue of its ability to further damage airway epithelial cells, influenza infection can lead to secondary bacterial proliferation and an increase in the frequency of AECB. Serological evidence of influenza A or B infection has been found in up to 28% of patients with AECB (126,321,322). In addition, COPD patients infected with influenza have a significant risk of requiring hospitalization (323).…”

Section: Prevention Of Aecbmentioning

confidence: 99%

Canadian Guidelines for the Management of Acute Exacerbations of Chronic Bronchitis

Balter

Forge

Low

et al. 2003

Canadian Respiratory Journal

116

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Acute exacerbations of chronic bronchitis (AECB) account for over 1.5 million physician visits annually in Canada and are a cause of significant morbidity and mortality. This document represents a joint effort between respirologists, microbiologists, infectious disease specialists and family physicians to update the Canadian AECB guidelines published in 1994. Treatment recommendations are graded on the strength of evidence in the published literature where possible. The role for oral corticosteroid therapy in preventing treatment failures, speeding up recovery and delaying the time to next exacerbation is discussed. Risk factors for treatment failure were used to stratify patients into risk groups to help guide antibiotic treatment recommendations. The importance of emerging antimicrobial resistance to current antibiotics is reviewed and strategies to prevent future AECB episodes are suggested.

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Section: Prevention Of Aecbmentioning

confidence: 99%

Canadian Guidelines for the Management of Acute Exacerbations of Chronic Bronchitis

Balter

Forge

Low

et al. 2003

Canadian Respiratory Journal

116

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“…Many agents have been found in association with exacerbations, but their relative importance has varied greatly in different studies. In particular, viruses have been identified with very variable frequency in several careful surveys (Somerville, 1963;Carilli et al, 1964;Eadie et al, 1966;Ross et al, 1966;Stenhouse, 1967;McNamara et al, 1969;Fisher et al, 1969). The paucity of viruses in some surveys is hard to reconcile with the common observation made in general practice that patients often have exacerbations of bronchitis when other members of the family are suffering mild, and presumably mainly viral, infection of the respiratory tract.…”

Section: Introductionmentioning

confidence: 99%

Infective Factors in Exacerbations of Bronchitis and Asthma

Lambert¹,

Stern²

1972

BMJ

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possible case of diabetes for the first time plasma glucose values ought to be reported. If anticoagulants interfere with the precipitating second antibody of double antibody insulin assay systems then separation of insulin ought to be achieved by other methods-for example, by adsorption to charcoal. They are equally efficient and simple to use.Glucose and insulin responses are being studied under widely varying circumstances-relation between mother and fetus, hypoglycaemic disturbances in the neonate, and the effects of new oral hypoglycaemic agents. Precise comparisons of data in these and other fields cannot be made unless glucose and insulin concentrations are determined on the same basis. An agreement on basic methodology will help to save a great deal of confusion in the future.

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“…Jack and Gandevia (1960) reported completely negative results but suggested that viruses not then identifiable might play a part in some exacerbations of chronic bronchitis. Since then it has become possible to isolate the rhinovirus group, but Carilli et al (1964), using suitable cultural conditions for this group of viruses, failed to isolate these agents; their survey covered a period of only eight BrrIass MEDICAL JOURNAL months, and their negative findings may have been due to the prevalent strain being particularly difficult to isolate (Tyrell and Bynoe, 1966). Some work in Glasgow (Eadie, Scott, and Grist, 1966) has provided evidence that the rhinoviruses may indeed play a part in chronic bronchitis.…”

Section: Discussionmentioning

confidence: 99%

“…Stark, Heath, and Curwen (1965) examined sera from outpatients in London at four-week intervals: 23 out of 199 patients showed evidence of viral infection, and in 13 this could be correlated with an exacerbation. A more comprehensive study was carried out by Carilli, Gohd, and Gordon (1964) in Boston: 46 cases of respiratory illness occurred, and 23 of these could be associated with viral infections; respiratory syncytial virus alone appeared to be responsible for 17%, but no common-cold viruses were isolated. Sommerville (1963) has also shown a high incidence of antibodies to respiratory syncytial virus in sera from chronic bronchitics in Glasgow.…”

Section: Persistence Of Viral Antibodies In Patients With Chronic Bromentioning

confidence: 99%