A versatile method for the synthesis of poly(glycolic acid): high solubility and tunable molecular weights

Şanko, Vildan; Şahin, İsa; Sezer, Ümran Aydemir; Sezer, Serdar

doi:10.1038/s41428-019-0182-7

Cited by 38 publications

(21 citation statements)

References 23 publications

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“…The range of melting temperature of PGA was reported to be 220–230 °C, indicating that PGA was successfully produced in this process . On the other hand, Sanko et al produced PGA with a Mw of 40,300 Da by the reaction at 170 °C for 30 h with triflic acid as a catalyst and anisole as the solvent . As a degradable polyester, PGA is extremely prone to degradation in the presence of water or water vapor, which has made PGA and its copolymer promising materials in medical fields for biodegradable bone grafts, dental materials, scaffolds in tissue engineering, and drug delivery vehicles .…”

Section: Resultsmentioning

confidence: 99%

Toward Low-Carbon-Footprint Glycolic Acid Production for Bioplastics through Metabolic Engineering in Escherichia coli

2023

ACS Sustainable Chem. Eng.

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Researchers are focusing on biological carbon dioxide abatement against the currently employed physical and chemical methods. Sustainable approaches for carbon conversion into indispensable bulk chemicals are the need of the hour. In this study, glycolic acid (GA), one of the promising components for bioplastics, food, and pharmaceutical industries, was produced in a low-carbon footprint manner using genetically engineeredEscherichia coli for the first time. By fine-tuning the genes in the TCA cycle and glyoxylate shunt, GA yield reached 0.21 g/g-glucose with a productivity of 0.08 g/L/h. Regeneration of NADPH was improved using glyceraldehyde-3-phosphate dehydrogenase (gapC) fromClostridium acetobutylicum in the glucose-6-phosphate-1-dehydrogenase (zwf) mutant. To further enhance CO2 uptake and carbon flux into the TCA cycle, phosphoenolpyruvate carboxylase (ppc) and pyruvate carboxylase (pyc) were applied. As a result, the titer and productivity of GA reached 11.9 g/L and 0.23 g/L/h, respectively, with a 41% reduction in CO2 emission compared to the strain without ppc expression during fermentation. Finally, GA was polymerized to form poly(glycolic acid) and characterized by Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). The presented strategy serves as an eco-friendly and cost-efficient approach for chemical production toward low-carbon emission.

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Section: Resultsmentioning

confidence: 99%

Toward Low-Carbon-Footprint Glycolic Acid Production for Bioplastics through Metabolic Engineering in Escherichia coli

2023

ACS Sustainable Chem. Eng.

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“…Sanko et al synthesized PGA of M n of 27,000 g mol -1 via azeotropic polycondensation at 154 o C over 30 hours using anisole as the solvent and triflic acid (TfOH) as the catalyst. 26 These polymerization techniques all require significantly longer reaction times as well as high catalyst concentrations. Thus, the resulting polymers will contain more catalyst impurities.…”

Section: Polycondensation From Glycolic Acidmentioning

confidence: 99%

Poly(glycolic acid) (PGA): a versatile building block expanding high performance and sustainable bioplastic applications

et al. 2020

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“…94 PGA has non-toxic degradation products and suitable biodegradability, biocompatibility and mechanical properties. 93 Owing to its hydrophilic nature and quick water uptake, PGA is not sustainable in vivo because PGA loses its mechanical strength usually over a period of 2 to 4 weeks after implantation and completely disappears several months after implantation. 94,110 In cardiovascular applications, PGA is usually applied as a temporary scaffold or support substrate.…”

Section: Poly(glycolic Acid)mentioning

confidence: 99%

<p>Biodegradable Nanopolymers in Cardiac Tissue Engineering: From Concept Towards Nanomedicine</p>

Nasr¹,

Rabiee²,

Hajebi³

et al. 2020

IJN

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Cardiovascular diseases are the number one cause of heart failure and death in the world, and the transplantation of the heart is an effective and viable choice for treatment despite presenting many disadvantages (most notably, transplant heart availability). To overcome this problem, cardiac tissue engineering is considered a promising approach by using implantable artificial blood vessels, injectable gels, and cardiac patches (to name a few) made from biodegradable polymers. Biodegradable polymers are classified into two main categories: natural and synthetic polymers. Natural biodegradable polymers have some distinct advantages such as biodegradability, abundant availability, and renewability but have some significant drawbacks such as rapid degradation, insufficient electrical conductivity, immunological reaction, and poor mechanical properties for cardiac tissue engineering. Synthetic biodegradable polymers have some advantages such as strong mechanical properties, controlled structure, great processing flexibility, and usually no immunological concerns; however, they have some drawbacks such as a lack of cell attachment and possible low biocompatibility. Some applications have combined the best of both and exciting new natural/ synthetic composites have been utilized. Recently, the use of nanostructured polymers and polymer nanocomposites has revolutionized the field of cardiac tissue engineering due to their enhanced mechanical, electrical, and surface properties promoting tissue growth. In this review, recent research on the use of biodegradable natural/synthetic nanocomposite polymers in cardiac tissue engineering is presented with forward looking thoughts provided for what is needed for the field to mature.

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A versatile method for the synthesis of poly(glycolic acid): high solubility and tunable molecular weights

Cited by 38 publications

References 23 publications

Toward Low-Carbon-Footprint Glycolic Acid Production for Bioplastics through Metabolic Engineering in Escherichia coli

Toward Low-Carbon-Footprint Glycolic Acid Production for Bioplastics through Metabolic Engineering in Escherichia coli

Poly(glycolic acid) (PGA): a versatile building block expanding high performance and sustainable bioplastic applications

<p>Biodegradable Nanopolymers in Cardiac Tissue Engineering: From Concept Towards Nanomedicine</p>

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