Abstract:Given the complexity of the tumor microenvironment, multiple strategies are being explored to tackle hypoxic tumors. The most efficient strategies combine several therapeutic modalities and typically requires the development of multifunctional nanocomposites through sophisticated synthetic procedures. Herein, the G‐quadruplex (G4)‐forming sequence AS1411‐A (d[(G2T)4TG(TG2)4A]) is used for both its anti‐tumor and biocatalytic properties when combined with hemin, increasing the production of O2 ca. two‐fold as c… Show more
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