A Versatile Carbon Monoxide Nanogenerator for Enhanced Tumor Therapy and Anti-Inflammation

Wang, Shibo; Zhang, Cheng; Chen, Zhaoxia; Ye, Jing‐Jie; Peng, Song; Rong, Lei; Liu, Chuan-Jun; Zhang, Xian‐Zheng

doi:10.1021/acsnano.9b00345

Cited by 94 publications

(60 citation statements)

References 41 publications

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“…Recently, the advent of photocatalytic nanomaterial has been used to induce in situ generation of CO in tumor tissue and avoid the risk of CO poisoning caused by exogenous administration of CO . For instance, a multifunctional CO nanogenerator based on partially oxidized tin disulfide nanosheet (polymer@POS@DOX, denoted as PPOSD) was engineered and developed for synergistic anticancer treatment and effective anti‐inflammation therapy . CO could be generated by PPOSD via CO 2 photoreduction upon the illumination with 561 nm laser.…”

Section: Carbon Monoxide Releasing Nanomaterialsmentioning

confidence: 99%

Emerging Delivery Strategies of Carbon Monoxide for Therapeutic Applications: from CO Gas to CO Releasing Nanomaterials

Yan

Zhu

et al. 2019

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Carbon monoxide (CO) therapy has emerged as a hot topic under exploration in the field of gas therapy as it shows the promise of treating various diseases. Due to the gaseous property and the high affinity for human hemoglobin, the main challenges of administrating medicinal CO are the lack of target selectivity as well as the toxic profile at relatively high concentrations. Although abundant CO releasing molecules (CORMs) with the capacity to deliver CO in biological systems have been developed, several disadvantages related to CORMs, including random diffusion, poor solubility, potential toxicity, and lack of on‐demand CO release in deep tissue, still confine their practical use. Recently, the advent of versatile nanomedicine has provided a promising chance for improving the properties of naked CORMs and simultaneously realizing the therapeutic applications of CO. This review presents a brief summarization of the emerging delivery strategies of CO based on nanomaterials for therapeutic application. First, an introduction covering the therapeutic roles of CO and several frequently used CORMs is provided. Then, recent advancements in the synthesis and application of versatile CO releasing nanomaterials are elaborated. Finally, the current challenges and future directions of these important delivery strategies are proposed.

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Section: Carbon Monoxide Releasing Nanomaterialsmentioning

confidence: 99%

Emerging Delivery Strategies of Carbon Monoxide for Therapeutic Applications: from CO Gas to CO Releasing Nanomaterials

Yan

Zhu

et al. 2019

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“…The emerging researches of carbon monoxide (CO) gas therapy have attracted widespread attention, including therapy of neurodegenerative diseases (Queiroga et al, 2015) and as an antibacterial (Wareham et al, 2015), anti-cancer (Wegiel et al, 2013;Wu et al, 2018a), and especially anti-inflammatory agent (He et al, 2015;Ji et al, 2016b;Popova et al, 2018;Zheng et al, 2018;Wang et al, 2019). Moreover, studies have revealed that CO serves as an endogenous signaling molecule and shows significant anti-inflammatory effects at low doses in many inflammation-related diseases (Otterbein et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Carbon Monoxide Controllable Targeted Gas Therapy for Synergistic Anti-inflammation

et al. 2020

iScience

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Carbon monoxide (CO) plays an important role in the regulation of a variety of physiological processes and thus is regarded as a promising pharmaceutical agent. Nevertheless, therapeutic applications of CO are severely hampered by the difficulty of the delivery of controlled amounts of CO to biological targets. To address this deficiency, we present a spatiotemporally controllable COreleasing platform (designated as Neu-MnO 2 /Fla) for synergistic anti-inflammation. With the assistance of neutrophil membrane coating, Neu-MnO 2 /Fla can target to inflammatory sites. Subsequently, excess H 2 O 2 at the inflamed tissues can be decomposed into oxygen because of MnO 2 as nanozymes possessing catalase (CAT) activity, which not only relieves oxidative stress but also achieves in situ rapid photo-induced CO release. The in vitro and in vivo results indicate our CO-releasing platform exhibits a strong synergistic anti-inflammatory effect. Our work will shed light on targeted CO release to avoid side effects of therapeutic applications of CO.

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“…Recently, carbon monoxide releasing molecule (CORM)‐derived CO has attracted attention as a potential therapeutic agent with versatile beneficial functions for tumor therapy and anti‐inflammation (S. B. Wang et al, 2019). Figure 1b displayed both the total amount of CO released and the rate of CO release.…”

Section: Resultsmentioning

confidence: 99%

Radiosensitivity enhancement by Co‐NMS‐mediated mitochondrial impairment in glioblastoma

Yang

Zhang

et al. 2020

Journal Cellular Physiology

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We investigated the radiosensitizing effects of Co‐NMS, a derivative of nimesulide based on a cobalt carbonyl complex, on malignant glioma cells. In the zebrafish exposed to Co‐NMS ranging from 5 to 20 μM, cell death and heat shock protein 70 expression in the brain and neurobehavioral performance were evaluated. Our data showed that Co‐NMS at 5 μM did not cause the appreciable neurotoxicity, and thereby was given as a novel radiation sensitizer in further study. In the U251 cells, Co‐NMS combined with irradiation treatment resulted in significant inhibition of cell growth and clonogenic capability as well as remarkable increases of G2/M arrest and apoptotic cell population compared to the irradiation alone treatment. This demonstrated that the Co‐NMS administration exerted a strong potential of sensitizing effect on the irradiated cells. With regard to the tumor radiosensitization of Co‐NMS, it could be primarily attributed to the Co‐NMS‐derived mitochondrial impairment, reflected by the loss of mitochondrial membrane potential, the disruption of mitochondrial fusion and fission balance as well as redox homeostasis. Furthermore, the energy metabolism of the U251 cells was obviously suppressed by cotreatment with Co‐NMS and irradiation through repressing mitochondrial function. Taken together, our findings suggested that Co‐NMS could be a desirable drug to enhance the radiotherapeutic effects in glioblastoma patients.

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A Versatile Carbon Monoxide Nanogenerator for Enhanced Tumor Therapy and Anti-Inflammation

Cited by 94 publications

References 41 publications

Emerging Delivery Strategies of Carbon Monoxide for Therapeutic Applications: from CO Gas to CO Releasing Nanomaterials

Emerging Delivery Strategies of Carbon Monoxide for Therapeutic Applications: from CO Gas to CO Releasing Nanomaterials

Carbon Monoxide Controllable Targeted Gas Therapy for Synergistic Anti-inflammation

Radiosensitivity enhancement by Co‐NMS‐mediated mitochondrial impairment in glioblastoma

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