A Venture to Discover the Treatment of Coronavirus Disease 2019 (COVID 19): SARS-CoV-2

Modern medicines for human use are required to comply with specific standards and regulation set forth by the concerned authorities. A simple and sensitive UV spectrophotometric method was developed and validated for the simultaneous determination of Potassium Clavulanate (PC) and Amoxicillin. As complementary of this work, an assay method for amoxicillin and potassium clavulanate mixtures was developed and validated; stress-testing and stability studies of amox/clav mixtures was carried out under specified conditions according to ICH and analyzed by using validated stability-indicating assay and related substances methods. Aim of this study was to test the validation of derivative spectrophotometric method in simultaneous determination the content amoxicillin and clavulanate potassium in dry syrup by derivative spectrophotometric method with zero crossing technique, in buffer phosphate pH 4,4-methanol (91:9) mixture.

Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Review on process validation of Amoxicillin Potassium Clavulanate Dry Syrup

Devi

Kumar

Jeet

et al. 2022

“…20 mg/kg of cefuroxime axetil suspension is similar to a 500 mg tablet for adults. Our kids on 15 or 20 mg/kg cefuroxime axetil suspension had a Cmax similar to those on broken tablets in 85% sucrose (27) . Cmax and AUC rose correspondingly over 10-20 mg/kg.…”

Section: Pharmacokinetics Of Cefueoxime Axetilsupporting

confidence: 51%

A Short Review on Cefueoxime Axetil Tablet

Kumar

Jeet²,

Devi³

et al. 2022

Cefuroxime axetil is a broad-spectrum antibiotic with a simple pharmacokinetic profile. The medicine treats otitis media, pharyngitis, sinusitis, CAP, and acute exacerbations of chronic bronchitis effectively and well. Cefuroxime axetil was beneficial in intravenous/oral sequential therapy for CAP, but dosage recommendations are not accessible in some countries. Cefuroxime axetil may be used to treat community-acquired infections, including those caused by -lactamase-producing respiratory bacteria. In an era of rapidly growing bacterial resistance, empirical treatment with cefuroxime axetil may assure the proper use of newer antibacterial medicines, reducing bacterial resistance to these drugs.

“…When development and stability statistics demonstrate container/closure extractables are below safe levels, this test can be omitted. [19,20] Reevaluate if container/closure or formulation changes.…”

Section: Gradientmentioning

confidence: 99%

“…Validate dissolving techniques using pharmacopoeial or non-pharmacopoeial equipment/circumstances. [19] Immediate-release formulations have single-point measurements. Multiple-point sampling is required for modified-release formulations.…”

Section: Gradientmentioning

confidence: 99%

A Comprehensive Review on Amoxicilin and Clavulanic Acid as Potential Antibacterial Agent

Jeet

Kumar²,

Singh³

et al. 2022

Suspensions comprise finely divided medication particles (the suspensoid) spread uniformly in a vehicle with or without stabilisers and other ingredients. Conventional oral suspension is ready-to-use and does not require reconstitution. Dry syrup is more bioavailable than tablets and capsules because it dissolves in water outside the mouth and enters the GI tract. GIT absorbs suspension quickly: Amoxicillin and clavulanic acid have been used since the 1970s. Despite having the same half-life as amoxicillin, clavulanic acid is protein-bound and heat unstable. It causes gastrointestinal side effects, including Clostridium difficile infection, and restricts amoxicillin oral combination doses. Due to clavulanic acid's b-lactamase tendency, the first amoxicillineclavulanic acid ratio was 4:1; currently it's 2:1, 7:1, 14:1, and 16:1. Few ratio comparisons exist. Amoxicillineclavulanic acid is often used as empiric therapy for WHO's Priority Infectious Syndromes in adults and children, resulting in large consumption. Some of these syndromes may be handled with a delayed antibiotic prescription approach or amoxicillin alone.