A vegetable oil-based organogel for use in pH-mediated drug delivery

Khuphe, Mthulisi; Mukonoweshuro, Blessing; Kazlauciunas, Algy; Thornton, Paul D.

doi:10.1039/c5sm02176f

Cited by 27 publications

(12 citation statements)

References 59 publications

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“…The XRD pattern of xerogel GO in DMF showedaseries of peaks with d-spacing values of 4.58, 2.23, and 1.49 with ar atio of 1:1/2:1/3 (Figure 4e and f), which was also in agreement with al amella structure. [84,85] Thei nterlayer distance was 4.58 nm, whichi sl ess than the length of two molecules, but longer than that of as ingle molecule, which indicates that GO is self-assembled into am ore tilted bilayer structure.…”

Section: Resultsmentioning

confidence: 94%

Steric‐Structure‐Dependent Gel Formation, Hierarchical Structures, Rheological Behavior, and Surface Wettability

Cao

Zhao

et al. 2016

Chemistry An Asian Journal

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A series of bicholesteryl-based gelators with different central linker atoms C, N, and O (abbreviated to GC, GN, and GO, respectively) have been designed and synthesized. The self-assembly processes of these gelators were investigated by using gelation tests, field-emission scanning electron microscopy, field-emission transmission electron microscopy, UV/Vis absorption, IR spectroscopy, X-ray diffraction, rheology, and contact-angle experiments. The gelation ability, self-assembly morphology, rheological, and surface-wettability properties of these gelators strongly depend on the central linker atom of the gelator molecule. Specifically, GC and GN can form gels in three different solvents, whereas GO can only form a gel in N,N-dimethylformamide (DMF). Morphologies from nanofibers and nanosheets to nanospheres and nanotubes can be obtained with different central atoms. Gels of GC, GN, and GO formed in the same solvent (DMF) have different tolerances to external forces. All xerogels gave a hydrophobic surface with contact angles that ranged from 121 to 152°. Quantum-chemical calculations indicate that the GC, GN, and GO molecules have very different steric structures. The results demonstrate that the central linker atom can efficiently modulate the molecular steric structure and thus regulate the supramolecular self-assembly process and properties of gelators.

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Section: Resultsmentioning

confidence: 94%

Steric‐Structure‐Dependent Gel Formation, Hierarchical Structures, Rheological Behavior, and Surface Wettability

Cao

Zhao

et al. 2016

Chemistry An Asian Journal

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“…More generally, vegetable oils (such as peanut oil, olive oil, soybean oil, etc.) are widely used to encapsulate hydrophobic drugs for drug delivery, [59][60][61][62] such as paclitaxel and camptothecin. 61,62 Given the known solubility of these drugs in a particular vegetable oil, the total amount that can be encapsulated primarily depends on the encapsulation efficiency of oil droplets in the oil-laden nanogels.…”

Section: Adaptability Of Double Nanoemulsion Nanogel Synthesis To Othmentioning

confidence: 99%

Synthesis of Oil-Laden Poly(ethylene glycol) Diacrylate Hydrogel Nanocapsules from Double Nanoemulsions

et al. 2017

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Multiple emulsions have received great interest due to their ability to be used as templates for the production of multi-compartment particles for a variety of applications.However, scaling these complex droplets to nanoscale dimensions has been a challenge due to limitations on their fabrication methods. Here, we report the development of oil-in-water-in-oil (O1/W/O2) double nanoemulsions via a two-step high-energy method, and their use as templates for complex nanogels comprised of inner oil droplets encapsulated within a hydrogel matrix.Using a combination of characterization methods, we determine how the properties of the nanogels are controlled by the size, stability, internal morphology, and chemical composition of the nanoemulsion templates from which they are formed. This allows for identification of 2 compositional and emulsification parameters that can be used to optimize the size and oil encapsulation efficiency of the nanogels. Our templating method produces oil-laden nanogels with high oil encapsulation efficiencies and average diameters of 200-300 nm. In addition, we demonstrate the versatility of the system by varying the types of inner oil, the hydrogel chemistry, the amount of inner oil, and the hydrogel network crosslink density. These non-toxic oil-laden nanogels have potential applications in food, pharmaceutical, and cosmetic formulations.

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“…48 The burst release from PGl-X-10 and PGl-X-20 was around 65 µg/mg PGl and 140 µg/mg PGl, respectively, which were higher than for the PGl-F sample (10 µg/mg PGl) due to greater amount of physisorbed IND on the fibre surfaces. By subtracting the burst release from the total amount of IND loaded into the samples, the total amounts of IND incorporated in the bulk of the fibers can be calculated which will only be released upon fibre erosion (not further studied here), 49,50 i.e. 90 µg/mg PGl for PGl-F, 145 µg/mg a higher drug loading is achievable by the swelling approach using crosslinked fibres but also that the total amount of drug can be controlled by the drug concentration in the swelling solution.…”

Section: Resultsmentioning

confidence: 99%

Direct UV-Triggered Thiol–ene Cross-Linking of Electrospun Polyester Fibers from Unsaturated Poly(macrolactone)s and Their Drug Loading by Solvent Swelling

et al. 2017

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Abstract. Electrospinning is considered a relative simple and versatile technique to form high porosity porous scaffolds with micron to nanoscale fibers for biomedical applications. Here, electrospinning of unsaturated aliphatic polyglobalide (PGl) into well-defined fibers with an average diameter of 9 µm is demonstrated. Addition of a dithiol crosslinker and a photoinitiator to the polymer solution enabled the UV-triggered intra-crosslinking of the fibers during the spinning process. The in-situ crosslinking of the fibers resulted in amorphous material able to swell up to 14% in tetrahydrofyrane (THF) without losing the fiber morphology. Seeding Mesenchymal Stem Cells (MSCs) onto both crosslinked and non-crosslinked PGl fibers proved their compatibility with MSCs and suitability as scaffolds for cell growth and proliferation of MSCs. Moreover, the ability to directly load crosslinked PGl with hydrophobic molecules by soaking the fiber mesh in solution is shown with Rhodamine B and Indomethacin, a hydrophobic anti-inflammatory drug. This marks an advantage over conventional aliphatic polyesters and opens opportunities for the design of drug loaded polyester scaffolds for biomedical applications or tissue engineering.

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A vegetable oil-based organogel for use in pH-mediated drug delivery

Abstract: Organogels prepared with vegetable oils as the liquid organic phase present an excellent platform for the controlled delivery of hydrophobic guest molecules.

Cited by 27 publications

References 59 publications

Steric‐Structure‐Dependent Gel Formation, Hierarchical Structures, Rheological Behavior, and Surface Wettability

Steric‐Structure‐Dependent Gel Formation, Hierarchical Structures, Rheological Behavior, and Surface Wettability

Synthesis of Oil-Laden Poly(ethylene glycol) Diacrylate Hydrogel Nanocapsules from Double Nanoemulsions

Direct UV-Triggered Thiol–ene Cross-Linking of Electrospun Polyester Fibers from Unsaturated Poly(macrolactone)s and Their Drug Loading by Solvent Swelling

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