A Vascular Patch Fabricated by Cosedimentating Polyurethane and Polymeric Nanoparticles onto a Decellularized Scaffold Facilitates Endothelialization

Zwitterionic Polymer-Grafted Polylactic Acid Vascular Patches Based on a Decellularized Scaffold for Tissue Engineering

“…PLA/DCS did not display the P 2p peak whereas PLA- g -poly­(AHEP)/DCS showed it at 134 eV because PLA does not contain phosphorus whereas AHEP does. The value of the P 2p peak for AHEP was consistent with those for sodium triphosphate (133.6 eV) and phosphatidylcholine (134 eV). , This indicated that AHEP was successfully grafted onto PLA/DCS. The thicknesses of DCS, PLA/DCS, and PLA- g -poly­(AHEP)/DCS were 0.95 ± 0.08, 1.07 ± 0.06, and 1.07 ± 0.08 mm.…”

“…In addition, the retained ECMs in the DCS can constitute a physiological microenvironment, deliver biochemical and cell signals, and guide cell attachment and growth. − Because of these characteristics, DCSs have attracted considerable attention in tissue engineering applications. − Nevertheless, DCSs are porous and cannot be used as vascular patches directly. Generally, before use, a DCS needs a coating with a polymeric film, such as a polyurethane (PU) or polylactic acid (PLA) film. , …”

Sodium triphosphate–capped silver nanoparticles on a decellularized scaffold-based polyurethane vascular patch for bacterial infection inhibition and rapid endothelialization

“…19,20 Moreover, the introduction of NPs does not change the material’s bulk properties, such as thermal stability and mechanical properties. 4,8 In this work, after AgNPs and Ag–STPP NPs were anchored onto the pure PU film, respectively, the resultant composite films AgNP/PU and Ag–STPP NP/PU had similar thermal stability and mechanical properties to the pure PU film (Supplemental Figures S2 and S3). In addition, anchoring AgNPs onto the pure PU film can prevent their aggregation, since the aggregation can induce a significant decrease in their antibacterial activity.…”

“…The P 2p peak position (133.9 eV) for STPP was consistent with that reported in our previous work (133.6 eV). 4 This suggested that Ag–STPP NPs were successfully incorporated into the surface of the PU film. The EDS spectrum of Ag–STPP NP/PU is shown in Figure 2(b).…”

“…Vascular patches have been extensively used to treat damaged or diseased blood vessels caused by cardiovascular diseases, a class of life-threatening diseases afflicting more than 10 million people worldwide. 1–6 For a damaged or diseased blood vessel, its innermost layer (i.e. endothelium) cannot function properly, which can lead to blood clotting, vessel blockage, and even death.…”