A variety of Helicobacter pylori strains colonize the stomach of non-bleeding Egyptian patients with upper gastrointestinal disorders

Eldeen, Loaa A. Tag; Mohamed, Mohamed A.; Awad, Mohamed M.; Sheir, Mohamed I; Shams, Tahany M.; Ragheb, Mostafa

doi:10.1186/s42269-019-0224-5

Cited by 4 publications

(3 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The prevalence of H. pylori infection in this study was higher in males than females and was statistically significant ( p = 0.00001), 17/43 (39.5%) of females versus 38/69 (55%) of males. This is matched with the previously investigated results in systemic meta‐analysis done on H. pylori 62,63 . In this study, the prevalence of H. pylori positive cases was correlated with the age of population.…”

Section: Discussionsupporting

confidence: 89%

See 1 more Smart Citation

Regulatory B cells (Bregs) in Helicobacter pylori chronic infection

et al. 2023

View full text Add to dashboard Cite

Helicobacter pylori are flagellated, spiral Gram-negative bacteria that persistently colonize the human stomach of approximately more than 50% of the population worldwide, 1,2 and up to 90% in Africa. 3 H. pylori is linked with a wide variety of diseases, such as gastro-duodenal diseases varying from chronic gastritis, gastric ulcers up to mucosa associated lymphoid tissue (MALT) lymphoma, and gastric cancer. H. pylori was the first bacteria proven to cause cancerous transformations and is currently classified as a group I carcinogen by the International Agency for Research on Cancer. 4

show abstract

Section: Discussionsupporting

confidence: 89%

“…This is matched with the previously investigated results in systemic metaanalysis done on H. pylori. 62,63 In this study, the prevalence of H. pylori positive cases was correlated with the age of population.…”

Section: F I G U R E 1 Flow Cytometry Analysis Of B Regulatory Cells ...mentioning

confidence: 76%

Regulatory B cells (Bregs) in Helicobacter pylori chronic infection

et al. 2023

View full text Add to dashboard Cite

show abstract

“…In the study of Mi et al [ 88 ] using cagA typing and RAPD-PCR fingerprinting, H. pylori strain isolated from patients showed heterogenicity that were considered to indicate the incidence of multiple infections. Overall, the different clinical outcomes during H. pylori infection may be due to differences in H. pylori strains—this could act as a marker to predict H. pylori disease outcomes [ 89 ].…”

Section: An Overview Of H Pylori Infectionmentioning

confidence: 99%

Helicobacter pylori: an up-to-date overview on the virulence and pathogenesis mechanisms

2022

View full text Add to dashboard Cite

Helicobacter pylori is an organism associated with ulcer disease and gastric cancer. The latter is one of the most prevalent malignancies and currently the fourth major cause of cancer-related deaths globally. The pathogen infects about 50% of the world population, and currently, no treatment ensures its total elimination. There has been an increase in our understanding of the pathophysiology and pathogenesis mechanisms of H. pylori over the years. H. pylori can induce several genetic alterations, express numerous virulence factors, and trigger diverse adaptive mechanisms during its adherence and colonization. For successful colonization and infection establishment, several effector proteins/toxins are released by the organism. Evidence is also available reporting spiral to coccoid transition as a unique tactic H. pylori uses to survive in the host’s gastrointestinal tract (GIT). Thus, the virulence and pathogenicity of H. pylori are under the control of complex interplay between the virulence factors, host, and environmental factors. Expounding the role of the various virulence factors in H. pylori pathogenesis and clinical outcomes is crucial for vaccine development and in providing and developing a more effective therapeutic intervention. Here we critically reflect on H. pylori infection and delineate what is currently known about the virulence and pathogenesis mechanisms of H. pylori .

show abstract

Comparison of invasive histological and molecular methods in the diagnosis of Helicobacter pylori from gastric biopsies of Sudanese patients: a cross-sectional study

et al. 2022

View full text Add to dashboard Cite

Background: The continuous rise in the number of patients suffering from Helicobacter pylori is probably due to the changes in modern life. Nowadays, patients suffering from gastrointestinal problems are diagnosed through invasive and non-invasive techniques. The choice of a diagnostic test is influenced by factors such as the tests' sensitivity and specificity, the clinical conditions, and the cost-effectiveness of the testing strategy. This study aimed to compare molecular detection methods of H. pylori by polymerase chain reaction (PCR) targeting the 16S rRNA, ureA and glmM genes with an invasive histopathological technique. Methods: 290 gastric biopsies were collected using gastrointestinal endoscopy from patients with gastritis symptoms in different hospitals in Khartoum state. Two gastric biopsies were collected from each patient for PCR and histopathology. Results: A total of 103 (35.5%) samples were positive by histopathological examination, 88 (30.3%) by 16S rRNA, 39 (13.4%) by glmM gene, and 56 (19.3%) by ureA gene. The highest sensitivity was observed in 16S rRNA (46.6%), followed by glmM (24.3%) and ureA (23.3%). While the best specificity was observed in glmM gene (92.5%), followed by ureA (82.3%) and 16S rRNA (78.6%). Conclusion: PCR test targeting the 16S rRNA gene exhibited the best results for molecular detection of H. pylori compared to other genes.

show abstract

A variety of Helicobacter pylori strains colonize the stomach of non-bleeding Egyptian patients with upper gastrointestinal disorders

Cited by 4 publications

References 44 publications

Regulatory B cells (Bregs) in Helicobacter pylori chronic infection

Regulatory B cells (Bregs) in Helicobacter pylori chronic infection

Helicobacter pylori: an up-to-date overview on the virulence and pathogenesis mechanisms

Comparison of invasive histological and molecular methods in the diagnosis of Helicobacter pylori from gastric biopsies of Sudanese patients: a cross-sectional study

Contact Info

Product

Resources

About