A VAPB e a Esclerose Lateral Amiotrófica

Chelate Complexes of 1,10-Phenanthroline and Related Compounds.

“…The symptoms caused by the complexes, i.e., torpor, tremor, paralysis of the limbs, clonic convulsions, an unaffected heart, and death due to respiratory failure, indicated an attack on the central nervous system. This has been supported by the finding that these substances are potent inhibitors of acetylcholinesterase (91, 92), and that they have a curare-like action on the neuromuscular transmission (25,94). Acetylcholinesterase is thought to have two active sites-a negatively charged one, and a so-called esteractic site.…”

“…*/ Fe(bipy)2++ + bipy <=> Fe(bipy)3++ (25) kb where equations 23 and 24 are rapidly established equilibria with constants Ki and K2, while equation 25 is the slow reaction having rate constants kf and fa for the forward and back reactions. The rate of formation is apparently independent of temperature.…”

“…Metal complexes of phenanthroline, bipyridine, and terpyridine have high biological activity. Toxicity to mice and rats (91) and to frogs and rabbits (20), bacteriostatic and bacteriocidal properties (91), and action on enzymes (91,92,200,224) and on neuromuscular transmission (25,94) have been demonstrated. The metal complexes used in these investigations were all coordinately saturated and highly stable chemically and had no specific active groups or centers.…”

“…It is unfortunate that a detailed account of Beccari's work is unavailable. Nervous conduction does not seem to be affected (25), but curare-like effects were obtained on the endplate potentials at synaptic junctions (25). Neuromuscular block was observed at low concentrations with rat diaphragm preparations (94); the response of the frog rectus abdominis preparation to acetylcholine was inhibited (94).…”

Intervenção fisioterapêutica no paciente com diagnóstico de esclerose lateral amiotrófica: uma revisão bibliográfica

“…A ELA ainda é considerada uma doença rara que causa incapacidade nos pacientes acometidos por ela, ainda não existe uma cura, porém alguns pacientes fazem uso do fármaco chamado Riluzol que é o único fármaco aprovado para o tratamento desses pacientes e que inibe a liberação pré-sináptica de glutamato (SARISLEYDIS et al, 2018).…”