A Vanadium(V) complexes derived from pyridoxal/salicylaldehyde. Interaction with CT-DNA/HSA, and molecular docking assessments

Newly synthesized palladium(ii) complexes with dialkyl esters of (S,S)-propylenediamine-N,N′-di-(2,2′-di-(4-hydroxy-benzil))acetic acid: in vitro investigation of biological activities and HSA/DNA binding

“…Using the viscometric method, possible intercalation, or non-intercalation of compounds into DNA nucleobases can be determined. 23 It is known that intercalation results in DNA elongation, due to the separation of base pairs at the intercalation site, which at the same time leads to an increase in the relative specific viscosity of such solutions. 24 The results of viscosity measurements of complexes C1–C4 were indicated that complexes are not performing intercalation between the DNA bases, and which probably bind to minor/major grooves.…”

Vanadium(v) complexes derived from triphenylphosphonium and hydrazides: cytotoxicity evaluation and interaction with biomolecules

“…On a Bruker AVANCE III 600 MHz spectrometer, the 1 H (600 MHz), 13 C (151 MHz), 19 F (565 MHz), 31 P (243 MHz), and 51 V (158 MHz) nuclear magnetic resonance (NMR) spectra were recorded at 298.1 K. Dimethyl sulfoxide (DMSO-d 6 ) or chloroform (CDCl 3 ) were used as deuterated solvents. Tetramethylsilane (Me 4 Si) was used as internal reference, while triphenylphosphane (PPh 3 ) in DMSO-d 6 solution and vanadium(V) trichloride oxide in deuterated benzene (90% VOCl 3 /C 6 D 6 solution) were used as external references.…”

“…27 There are also reports on the synthesis and structural characterization of vanadium(V) complexes containing tridentate hydrazone ligands with O,N,O topology, as well as their corresponding interaction with both DNA and serum albumin. [28][29][30][31] Notably, our group has synthesized and evaluated the interactive profile with DNA and HSA of some vanadium-based compounds, e.g., two series of vanadium(V) complexes derived from pyridoxal hydrochloride or salicylaldehyde and p-substituted benzoic hydrazides. 31 One approach to increasing the efficiency and decreasing the side effects of new medicines is the development of targeted drugs.…”

“…[28][29][30][31] Notably, our group has synthesized and evaluated the interactive profile with DNA and HSA of some vanadium-based compounds, e.g., two series of vanadium(V) complexes derived from pyridoxal hydrochloride or salicylaldehyde and p-substituted benzoic hydrazides. 31 One approach to increasing the efficiency and decreasing the side effects of new medicines is the development of targeted drugs. 32 A target of interest is mitochondria, an organelle responsible for generating cellular energy in adenosine triphosphate (ATP) form and regulating and triggering the intrinsic pathway of apoptosis.…”

“…39,40 The solid-state structures of these inorganic complexes were thoroughly elucidated using single-crystal X-ray crystallography. Additionally, the complexes underwent comprehensive characterization through various techniques, including vibrational spectroscopy and elemental analysis in the solid state, as well as UV-Vis absorption, cyclic voltammetry, and 1 H, 19 F, 31 P, and 51 V-nuclear magnetic resonance in solution.…”