“…We reviewed the published literature and found that ROS1 protein was expressed frequently in ROS1-non-rearranged cases. We also found and that, in all, 37 ROS1-non-rearranged cases with IHC 2-3 + or high H-scores had been reported to date (Table 4), 10,12,14,15,19,20 posing a challenge for the screening of ROS1-rearranged lung cancer. However, knowledge regarding how to distinguish real ROS1rearranged cases from discordant cases is limited.…”