A validated UPLC-MS/MS method to determine free and total irinotecan and its two metabolites in human plasma after intravenous administration of irinotecan hydrochloride liposome injection

Zhuang, Quankun; Liu, Xuemei; Sun, Zhengyi; Wang, Hongyun; Jiang, Ji

doi:10.1016/j.jpba.2019.03.034

Cited by 13 publications

(5 citation statements)

References 21 publications

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“…and Basu et al. to retain and separate the analytes of interest [17, 18]. Though the retention time of irinotecan, SN38 and SN38G was short, some small ion suppression was still observed.…”

Section: Resultsmentioning

confidence: 99%

“…The polar endogenous components could be eluted in the short retention time in the C 18 column even with a high aqueous phase [13][14][15][16]. In the preliminary study, we used the elution programs developed by Zhuang et al and Basu et al to retain and separate the analytes of interest [17,18]. Though the retention time of irinotecan, SN38 and SN38G was short, some small ion suppression was still observed.…”

Section: Methods Developmentmentioning

confidence: 99%

See 1 more Smart Citation

A validated high‐performance liquid chromatography‐tandem mass spectrometry method for simultaneous determination of irinotecan and two major metabolites in rat plasma: Application for the pharmacokinetics study

Liangzhu,

Nan,

Yuzhi

et al. 2024

Separation Science Plus

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A high‐performance liquid chromatography‐tandem mass spectrometry method has been developed for the determination of irinotecan, 7‐ethyl‐10‐hydroxycamptothecin (SN38), and SN38 glucuronide (SN38G) in rat plasma in the present study. The analytes were separated on a C18 column and a triple‐quadrupole mass spectrometry equipped with an electrospray ionization source was applied for detection. Irinotecan, SN38 and SN38G could be well retained in the C18 column after optimization of mobile phase. A simple protein precipitation was used to pretreat the plasma. The extraction recovery was above 90% and the matrix effect could be negligible. The method was linear over the concentration ranges of 3.46–3458.8 ng/mL for irinotecan, 2.53–2530.0 ng/mL for SN38 and 2.5–2500.0 ng/mL for SN38G. The precision and accuracy was within the acceptable limits. The simple and convenient method was validated and successfully applied to support the pharmacokinetic study and elucidate the mechanism of irinotecan‐induced diarrhea after irinotecan was intravenously injected to the Sprague‐Dawley rats.

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“…and Basu et al. to retain and separate the analytes of interest [17, 18]. Though the retention time of irinotecan, SN38 and SN38G was short, some small ion suppression was still observed.…”

Section: Resultsmentioning

confidence: 99%

Section: Methods Developmentmentioning

confidence: 99%

A validated high‐performance liquid chromatography‐tandem mass spectrometry method for simultaneous determination of irinotecan and two major metabolites in rat plasma: Application for the pharmacokinetics study

Liangzhu,

Nan,

Yuzhi

et al. 2024

Separation Science Plus

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“…Liposomes are microcapsules (Figure 7b) that can encapsulate both hydrophilic and hydrophobic drugs [109]. Commonly designed for targeted delivery or lymphatic orientation, liposomes can be administered in various routes, such as intravenous injection [110], oral administration [111], intraocular administration [112], pulmonary administration [113] and external use (including skin administration) [114] according to clinical needs. With the drug encapsulated in the lipid-like bilayer, the stability of the drug is enhanced by minimizing excretion and metabolism in a sustained release manner, which conduces to reduce the toxicity of the drug [115].…”

Section: Liposomesmentioning

confidence: 99%

Solubility and Bioavailability Enhancement of Oridonin: A Review

et al. 2020

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Oridonin (ORI), an ent-kaurene tetracyclic diterpenoid compound, is isolated from Chinese herb Rabdosia rubescens with various biological and pharmacological activities including anti-tumor, anti-microbial and anti-inflammatory effects. However, the clinical application of ORI is limited due to its low solubility and poor bioavailability. In order to overcome these shortcomings, many strategies have been explored such as structural modification, new dosage form, etc. This review provides a detailed discussion on the research progress to increase the solubility and bioavailability of ORI.

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“…CPT-11 is an excellent candidate drug for which to develop a drug sensor, because it has a narrow therapeutic index and because it exhibits wide inter-individual differences in pharmacokinetic and pharmacodynamic behavior [ 20 , 21 ]. A variety of methods to detect CPT-11 have been reported, including electrochemical analysis [ 17 , 22 ], high-performance liquid chromatography coupled to tandem mass spectrometry [ 23 , 24 ], and reversed-phase high-performance coupled to liquid chromatography coupled to UV detection [ 25 ]. Although these methods can analyze and detect CPT-11, they have complex operations, long assay times, and the measurement requires a centralized and well-equipped laboratory and skilled operators.…”

Section: Introductionmentioning

confidence: 99%

Lanthanide (Eu3+/Tb3+)-Loaded γ-Cyclodextrin Nano-Aggregates for Smart Sensing of the Anticancer Drug Irinotecan

Guo

Liu

Tang

et al. 2022

IJMS

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The clinical use of anticancer drugs necessitates new technologies for their safe, sensitive, and selective detection. In this article, lanthanide (Eu3+ and Tb3+)-loaded γ-cyclodextrin nano-aggregates (ECA and TCA) are reported, which sensitively detects the anticancer drug irinotecan by fluorescence intensity changes. Fluorescent lanthanide (Eu3+ and Tb3+) complexes exhibit high fluorescence intensity, narrow and distinct emission bands, long fluorescence lifetime, and insensitivity to photobleaching. However, these lanthanide (Eu3+ and Tb3+) complexes are essentially hydrophobic, toxic, and non-biocompatible. Lanthanide (Eu3+ and Tb3+) complexes were loaded into naturally hydrophilic γ-cyclodextrin to form fluorescent nano-aggregates. The biological nontoxicity and cytocompatibility of ECA and TCA fluorescent nanoparticles were demonstrated by cytotoxicity experiments. The ECA and TCA fluorescence nanosensors can detect irinotecan selectively and sensitively through the change of fluorescence intensity, with detection limits of 6.80 μM and 2.89 μM, respectively. ECA can safely detect irinotecan in the cellular environment, while TCA can detect irinotecan intracellularly and is suitable for cell labeling.

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A validated UPLC-MS/MS method to determine free and total irinotecan and its two metabolites in human plasma after intravenous administration of irinotecan hydrochloride liposome injection

Cited by 13 publications

References 21 publications

A validated high‐performance liquid chromatography‐tandem mass spectrometry method for simultaneous determination of irinotecan and two major metabolites in rat plasma: Application for the pharmacokinetics study

A validated high‐performance liquid chromatography‐tandem mass spectrometry method for simultaneous determination of irinotecan and two major metabolites in rat plasma: Application for the pharmacokinetics study

Solubility and Bioavailability Enhancement of Oridonin: A Review

Lanthanide (Eu3+/Tb3+)-Loaded γ-Cyclodextrin Nano-Aggregates for Smart Sensing of the Anticancer Drug Irinotecan

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