A validated pangenome-scale metabolic model for theKlebsiella pneumoniaespecies complex
Helena B. Cooper,
Ben Vezina,
Jane Hawkey
et al.
Abstract:TheKlebsiella pneumoniaeSpecies Complex (KpSC) is a major source of nosocomial infections globally with high rates of resistance to antimicrobials. Consequently, there is growing interest in understanding virulence factors and their association with cellular metabolic processes for developing novel anti-KpSC therapeutics. Phenotypic assays have revealed metabolic diversity within the KpSC, but metabolism research has been neglected due to experiments being difficult and cost-intensive.Genome-scale metabolic mo… Show more
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