A validated non-aqueous potentiometric titration method for quantitative determination of alprazolam from pharmaceutical preparation

Rajan, V Rele; Prathamesh, P Tiwatane

doi:10.5958/0974-4150.2016.00080.8

Cited by 4 publications

(2 citation statements)

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“…But Lafutidine is soluble and stable 1 in acidic medium. A survey on literature revealed that few UV-Spectrophotometric 2-7 , Spectrofluorimetric 8 , High performance liquid chromatographic [9][10][11][12][13][14][15][16][17][18] and other 19 methods were available for the estimation of the titled drug. However, according to the knowledge of the author no visible spectrophotometric method was reported so far.…”

Section: Fig 1: Structure Of Lafutidinementioning

confidence: 99%

Untitled

2015

IJPSR

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A simple, sensitive, highly accurate method has been developed for the determination of Lafutidine in bulk sample and dosage forms. This method is based on the oxidative coupling reaction of drug with 3-methyl-2-benzothialinone hydrazine hydrochloride (MBTH) reagent in the presence of ferric chloride to form green colored chromogen exhibiting maximum absorption at 630 nm. Beer's law was obeyed and quantitative results were obtained in the range of 1-18µg/mL. The results of the analysis for the methods have been validated statistically. INTRODUCTION: Lafutidine, a newly developed histamine H(2)-receptor antagonist, inhibits gastric acid secretion. It is currently marketed in Japan, China and India. It is not only suppresses gastric acid secretion, but also possesses cytoprotective properties. After oral administration, Lafutidine is quickly absorbed in the GIT. The plasma protein binding ability of Lafutidine is 88%. The drug is predominantly metabolized via CYP2D6 and CYP3A4 enzymes.

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Section: Fig 1: Structure Of Lafutidinementioning

confidence: 99%

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2015

IJPSR

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“…The combination of Ambroxol hydrochloride with Fexofenadine hydrochloride used clinically for treatment and prophylaxis of allergic rhinitis, cold and flu. Literature survey reveals that Spectrophotometric (Polawar et al, 2008;Lata et al, 2012;Narayana et al, 2010;Vekaria et al, 2011;Amrithraj et al, 2011;Rahul et al, 2013;Ponnilavasaran et al, 2011;Nagras et al, 2012), Conductometric (Asjour et al, 2013), HPTLC (Vekaria et al, 2012;Sharma et al, 2010;Tandulwadkar et al, 2012), Potentiometric (Rajan et al, 2013), RP-UPLC (Bhupendrasinh et al, 2012), HPLC (Prasanth et al, 2012;Tamilselvi et al, 2012;Krishna et al, 2013;Ravisankar et al, 2012;Hashem et al, 2013;Mounika et al, 2012;Moses et al, 2013;Nidhi et al, 2012;Kamarupa et al, 2010;Khedkar et al, 2012;Suresh et al, 2012;Manasa et al, 2013), methods have been reported for their individual analysis, along with other combinations in pharmaceutical formulation and biological fluids. To the best of our knowledge no HPLC method of analysis has yet been reported for simultaneous analysis of AMB and FEX.…”

Section: Introductionmentioning

confidence: 99%

RP-HPLC Method for the Simultaneous Estimation of Ambroxol Hydrochloride and Fexofenadine Hydrochloride in bulk and in a Tablet Mixture

Buchupalli¹,

Srinivas²

2015

J App Pharm Sci

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A simple, rapid and precise reverse phase liquid chromatographic (RP-HPLC) method was developed and subsequently validated for simultaneous estimation of Ambroxol hydrochloride and Fexofenadine hydrochloride in bulk drug and in a synthetic mixture. The method is based on High Performance Liquid Chromatography (HPLC) on a reversed -phase column, Hypersil ODS C18 (Hypersil ODS 250 x 4.6 mm, 5, Make: Thermo Scientific) prepacked column. The separation was carried out using a mobile phase containing a buffer and acetonitrile (56:44 v/v), was pumped at a flow rate of 0.8 mL/min, column temperature at 35º C using UVdetection at 225 nm. Both the drugs were well resolved on the stationary phase and the retention times were around 2.424 minute for Ambroxol hydrochloride and 3.753 minute for Fexofenadine hydrochloride. The method was validated and shown to be linear for both the drugs. The correlation coefficients for Ambroxol hydrochloride and Fexofenadine hydrochloride are 0.9994 and 0.9992 respectively.

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Validation of the Quantitative Determination Method of the active substance in Angiolin eye drops by spectrophotometry

I. Kucherenko,

R. Akopian,

О. Portna

et al. 2024

RJPT

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Today, cataracts are the main cause of vision loss. Therefore, the creation of new ophthalmic medicines (drugs), namely eye drops, based on the active substance angiolin ((S)-2,6-diaminohexanoic acid 3-methyl-1,2,4-triazolyl-5-thioacetate) is an urgent task. Previously, we developed a method of standardization of the active substance – by the spectrophotometry. According to the requirements of the SPhU, the next step was the validation of the developed methods. That became the purpose of our work. Validation of the method of quantitative determination of active substances was carried out according to the following indicators: specificity, linearity, range of application, accuracy, correctness and robustness. In the course of the conducted studies, it was established that the method is characterized by sufficient convergence and correctness, as the criterion of insignificance of the systematic error of the method is fulfilled. The systematic error of the method satisfies the requirements of statistical and practical insignificance. The high value of the correlation coefficient r = 1.0000 and 0.99994 satisfies the requirements of the acceptance criterion (r = 0.9998) and confirms the linearity of the dependence between the amount of Angiolin taken and found in the range from 80% to 120%, according to its nominal content in the drug. The requirements for the linear dependence parameters (a, SD0/b, r) of the Angiolin determination method are met in the entire concentration range from 80% to 120% of the nominal value. Thus, the developed method of standardization of active substances in Angiolin eye drops is valid and can be introduced into the project of QCM (quality control methods).

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A validated non-aqueous potentiometric titration method for quantitative determination of alprazolam from pharmaceutical preparation

Cited by 4 publications

References 0 publications

Untitled

Untitled

RP-HPLC Method for the Simultaneous Estimation of Ambroxol Hydrochloride and Fexofenadine Hydrochloride in bulk and in a Tablet Mixture

Validation of the Quantitative Determination Method of the active substance in Angiolin eye drops by spectrophotometry

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