A validated non-aqueous potentiometric titration method for quantitative determination of clopidogrel bisulphate from pharmaceutical preparation

Rajan, V Rele; Prathamesh, P Tiwatane

doi:10.5958/0974-4150.2017.00004.9

Cited by 3 publications

(1 citation statement)

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“…Titration is a quantitative analysis method used to determine the concentration of many active pharmaceutical ingredients such as tetraphenylborate sodium, phenothiazine compounds, acetaminophen, captopril, ascorbic acid, albendozole, sparfloxacin, salbutamol sulfate, montelukast sodium, phenylephrine hydrochloride, candesartan cilexetil [7][8][9][10][11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Status of Hydrogen Peroxide Solution 10 V in Commercialized Samples

Mn¹,

Ac²,

Hrn³

2017

Pharm Anal Acta

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Hydrogen peroxide (H 2 O 2 ) is one of the most powerful oxidants used in many sectors. Analytical method such as titration by permanganometry is used to maintain the quality of products containing H 2 O 2 . Thus, the objective of this work was to evaluate commercial samples of H 2 O 2 10 V by permanganometry. A difference of almost 3 volumes was found in the analysis of the samples. These results can be real or assigned to the potassium permanganate solution, not automation of the results and/or instability of the H 2 O 2 solutions, for example. The main issue is, in addition to alerting the consumers to adequate storage of H 2 O 2 solutions, to alert the scientific community to the need for concomitant analysis methods for unstable products such as H 2 O 2 10 V solutions in order to avoid doubts on the results and make the manufacturers aware of these quality tests.

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Section: Introductionmentioning

confidence: 99%

Status of Hydrogen Peroxide Solution 10 V in Commercialized Samples

Mn¹,

Ac²,

Hrn³

2017

Pharm Anal Acta

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Voltammetric Detection of Clopidogrel in Pharmaceuticals Utilizing Electropolymerized o-Aminophenol-MWCNTs Modified Electrode

Bahareh Feyzi-barnaji,

Barin,

Mohammadi

et al. 2023

Russ J Electrochem

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An Accurate and Precise Analytical Method for Estimation of Active Sulfur Trioxide and Sulfuric acid in Triethylamine Sulfur Trioxide Complex

Ahirrao

Jadhav

et al. 2022

AJPA

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Triethylamine sulfur trioxide complex (TEA-SO3) is an important sulfating agent used in the synthesis of various drug substances, dyes and other chemicals. Quality of TEA-SO3 is very crucial because it provides the active sulfur trioxide (SO3) in the sulfation reaction. We developed an accurate, precise and robust analytical method for determination of quality of TEA-SO3. The potentiometric titrimetry methods are capable to estimate SO3 as well as degradation product sulfuric acid (H2SO4) present in the TEA-SO3. Estimation of SO3 involves hydrolysis of the complex using H2SO4 under reflux condition and titrating excess H2SO4 against alkali solution. H2SO4 is quantified by direct titration against alkali solution. Both assay and impurity quantification methods were validated as per the ICH guideline. Accuracy of H2SO4 determination was 102.80% with precision of 0.75% and could be detected as low as 0.01%. Method to estimate SO3 was accurate with recovery of 99.92% and precision of 0.25%. The developed methods were employed for quality check of the reagent.

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A validated non-aqueous potentiometric titration method for quantitative determination of clopidogrel bisulphate from pharmaceutical preparation

Cited by 3 publications

References 0 publications

Status of Hydrogen Peroxide Solution 10 V in Commercialized Samples

Status of Hydrogen Peroxide Solution 10 V in Commercialized Samples

Voltammetric Detection of Clopidogrel in Pharmaceuticals Utilizing Electropolymerized o-Aminophenol-MWCNTs Modified Electrode

An Accurate and Precise Analytical Method for Estimation of Active Sulfur Trioxide and Sulfuric acid in Triethylamine Sulfur Trioxide Complex

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