A validated non-aqueous potentiometric titration method for quantitative determination of bromhexine hydrochloride from pharmaceutical preparation

Rajan, V Rele; Prathamesh, P Tiwatane

doi:10.5958/0974-4150.2020.00048.6

Cited by 1 publication

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“…Rupatadine is a second-generation non-sedating antihistaminic medicine which is selective and long-acting with a strong antagonist activity toward both histamine H1 receptors and platelet-activating factor receptors [ 8 ]. RUP can be determined via UV spectrophotometry [ 9 ], RP-HPLC [ 10 ], voltammetry [ 11 ], HPTLC [ 12 ], and by non-aqueous titration technique [ 13 ]. Montelukast sodium (MKT); Fig.…”

Section: Introductionmentioning

confidence: 99%

Environmentally benign liquid chromatographic method for concurrent estimation of four antihistaminic drugs applying factorial design approach

Ghonim,

Tolba,

Ibrahim

et al. 2024

BMC Chemistry

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In the last few decades, green analytical chemistry (GAC) has become a smart magical solution for the qualification and quantification of many drugs. In the current study, a direct, sensitive, and green RP-HPLC method was used to separate three anti-histaminic combinations rupatadine/montelukast, desloratadine/montelukast, fexofenadine/montelukast, and finally a mixture of rupatadine and its metabolite; desloratadine in less than 20 min. The developed method was optimized by a 23 full factorial design to improve the chromatographic responses. The proposed method was used to analyze these antihistaminic combinations at different pharmaceutical ratios. The linearity range is from 1 to 10 µg/mL for rupatadine, desloratadine, and montelukast, while for fexofenadine from 1 to 24 µg/mL drugs. The proposed method is useful in common quality control analysis of the investigated quaternary combinations because of its non-toxic and eco-friendly effects on the environment and human beings. The proposed procedure was thoroughly validated in accordance with ICH guidelines and was revealed to be accurate, reproducible, and selective. The developed methods were compared with a reported reference comparison method, where no significant difference was observed.

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