A validated method for the determination and purity evaluation of benazepril hydrochloride in bulk and in pharmaceutical dosage forms by liquid chromatography

Simultaneous determination of lercanidipine, benazepril and benazeprilat in plasma by LC–MS/MS and its application to a toxicokinetics study

“…It is reported that analytes of the lercanidipine, benazepril and benazeprilat were identified by HPLC [9][10][11][12]2,13,14], derivative spectrophotometry [15][16][17][18][19], capillary electrophoresis (CE) [20], high performance thin layer chromatography (HPTLC) [21], gas chromatography-mass spectrometry [22] and liquid chromatography-mass spectrometry [1,20,23]. Few methods are reported for the assay of combination drug products containing two or more active drug substances [12].…”

“…Few methods are reported for the assay of combination drug products containing two or more active drug substances [12]. Most of published methods only monitored the quality of the pharmaceutical dosage forms [10][11][12]2,[13][14][15][16][17][18][19]21]. However, it is really important to analyze the compounds in body fluids.…”

New clopidogrel napadisilate salt and its solid dispersion with improved stability and bioequivalence to the commercial clopidogrel bisulphate salt in beagle dogs

“…To investigate the comparative stability of clopidogrel napadisilate and clopidogrel bisulphate, they were kept at the accelerated condition of 40 • C/75% RH for 7 weeks (Radhakrishna et al, 2000;Raijada et al, 2010). Their water content, drug content and degradants were analysed at pre-determined time intervals.…”

Stability indicating RP-HPLC method for simultaneous determination of amlodipine and benazepril hydrochloride from their combination drug product

“…HPLC [6][7][8][9][10][11][12][13], HPTLC [14][15][16], OPLC [17], SFC [18], UV spectrophotometry [19][20][21][22][23][24][25][26][27][28][29][30][31], and MEKC [32] for its determination from pharmaceuticals. Similarly, survey of literature for BH revealed methods based on HPLC [33][34][35][36][37][38][39][40], HPTLC [41], UV spectrophotometry [42][43][44][45][46][47], eletroanalytical techniques [48,49], and CE [50][51][52] for its determination from pharmaceuticals. Only one method [13] has been reported for simultaneous determination of AM and BH, which describes an RP-HPLC procedure using C18 column, but this method lacks stabil...…”

“…Only one method [13] has been reported for simultaneous determination of AM and BH, which describes an RP-HPLC procedure using C18 column, but this method lacks stability indicating nature. A stability indicating LC method with gradient elution has been reported for determination of BH [35]. None of the reported analytical procedures describe a stability indicating method for simultaneous determination of AM and BH in presence of their degradants.…”