A validated chiral LC method for the determination of Zolmitriptan and its potential impurities

Srinivasu, M.K.; Rao, B.M.; Sridhar, G.; Kumar, Pramod; Chandrasekhar, K. B.; Islam, Aminul

doi:10.1016/j.jpba.2004.10.021

Cited by 26 publications

(17 citation statements)

References 8 publications

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“…Recently, a validated chiral LC method for the determination of zolmitriptan and its potential impurities was reported [4]. So far, to our present knowledge, no stability indicating analytical method for zolmitriptan was available in literature.…”

Section: Introductionmentioning

confidence: 99%

A stability indicating LC method for zolmitriptan

Rao

Srinivasu

Sridhar

et al. 2005

Journal of Pharmaceutical and Biomedical Analysis

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Section: Introductionmentioning

confidence: 99%

A stability indicating LC method for zolmitriptan

Rao

Srinivasu

Sridhar

et al. 2005

Journal of Pharmaceutical and Biomedical Analysis

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“…High-performance liquid chromatography (HPLC) with UV-detection has been widely used for the quantitative determination of ZMT in pharmaceuticals [8][9][10][11][12][13][14][15]. Ultraperformance liquid chromatography (UPLC) [16], liquid chromatography-mass spectrometry [17], voltammetry [18], and UV-spectrophotometry methods [19][20][21] are the other techniques applied for the assay of ZMT in pharmaceuticals.…”

Section: Introductionmentioning

confidence: 99%

“…Most of the reported methods [8][9][10][11][12][13][14][15][16][17][18][19][20][21] require expensive instrumental setup, expertise personnel, and complicated procedure. Two of the reported visible spectrophotometric methods [23] require liquid-liquid extraction and strict pH control.…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric Determination of Zolmitriptan in Bulk Drug and Pharmaceuticals Using Vanillin as a Reagent

Prashanth

Basavaiah

Raghu

2013

ISRN Analytical Chemistry

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An accurate and precise spectrophotometric method is presented for the determination of zolmitriptan (ZMT) based on the formation of a red color product with vanillin in presence of concentrated H 2 SO 4 , with the chromogen being measured at 580 nm. The reaction proceeds quantitatively at room temperature in 10 min. The calibration curve is linear over the range 5.0-90.0 g mL and described by the regression equation = (−)0.0101+0.0117 with a regression coefficient ( ) of 0.9994 ( = 7). The calculated molar absorptivity and Sandell sensitivity values are 3.3 × 10 3 L mol −1 cm −1 and 0.0872 g cm −2 , respectively. The limits of detection (LOD) and quantification (LOQ) calculated as per ICH guidelines are 1.26 and 3.81 g mL −1 , respectively. The within-day accuracy expressed as relative error was better than 1.78% with precision (RSD) ranging from 0.83 to 1.45%. The between-day accuracy ranged from 1.21 to 1.84% with a precision less than 1.66%. The method was successfully applied to the analysis of one brand of tablet containing zolmitriptan. The results obtained were in agreement with those obtained by published reference method. The accuracy was also checked by placebo blank and synthetic mixture analyses besides recovery study via standard addition procedure.

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“…Chemical structure of zolmitriptan A few techniques had been reported in the literature for zolmitriptan quantitation in plasma samples coulometric detection, liquid chromatography tandem mass spectroscopy, liquid chromatography with florescence detection and chiral liquid chromatographic method for drug determination and its impurities [5][6][7][8] .…”

Section: Introductionmentioning

confidence: 99%

Validated Uv Spectroscopic Method for Estimation of Zolmitriptan From Tablet Formulations

Rao¹,

Humaira²,

Munde³

2011

Int J of Biomed & Adv Res

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A simple, economical, sensitive and specific UV spectrophotometric method was developed for the estimation of Zolmitriptan in bulk drug tablet dosage form. The optimum conditions for the analysis of the drug were established. The wavelength maxima (λmax) for zolmitriptan were found to be 226.5 nm. The linearity for this method was found to be in the range of 1-5µg/ml. The method showed high sensitivity with reproducibility in results. The lower limit of detection and the limit of quantification were found to be 4.234and 12.702 respectively. The calibration curve was drawn by plotting graph between absorbance and concentration. Coefficient of correlation was 0.99. The regression of the curve was Y = 0.1751x +0.0476. Precision of the method was found to be 1.625 ± 0.324 against the label claim of 2.5mg. The percentage recovery was found to be 98.66 -99.50. The sample solution was stable up to 12 hours. The proposed method may be suitably applied for the analysis of Zolmitriptan in tablet pharmaceutical formulation for routine analysis

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A validated chiral LC method for the determination of Zolmitriptan and its potential impurities

Cited by 26 publications

References 8 publications

A stability indicating LC method for zolmitriptan

A stability indicating LC method for zolmitriptan

Spectrophotometric Determination of Zolmitriptan in Bulk Drug and Pharmaceuticals Using Vanillin as a Reagent

Validated Uv Spectroscopic Method for Estimation of Zolmitriptan From Tablet Formulations

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