A Validated Chiral Chromatography Method for Enantiomeric Separation of Pomalidomide in Human Plasma
Gyan Vardhan,
Vikas Kumar,
Puran Lal Sahu
et al.
Abstract:In the present work, new chiral stationary phase high-performance liquid chromatography (CSP-HPLC) method was established and validated for the quantification of pomalidomide (PMD) enantiomers in human plasma. The chromatographic enantiomeric separation was achieved on a Daicel-CSP, Chiralpack IA 4.6 × 250 mm, 5 μm; because of its advantages of high degree of retention, high resolution capacity, better reproducibility, ability to produce lower back pressure and low degree of tailing. The mobile phase was maint… Show more
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