A Vagal-NTS Neural Pathway that Stimulates Feeding

Chen, Jing; Cheng, Mingxiu; Wang, Liang; Zhang, Lei; Xu, Dan; Cao, Peng; Wang, Fengchao; Herzog, Herbert; Song, Sen; Zhan, Cheng

doi:10.1016/j.cub.2020.07.084

Cited by 86 publications

(76 citation statements)

References 54 publications

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“…Brain sections to a thickness of 30 μm were prepared using a cryostat (Leica, CM3050S) and collected in DPEC-treated PBS. Fluorescence in situ hybridization (FISH) was performed as previously described ( Chen et al, 2020 ) with minor modifications. Briefly, brain sections were rinsed with DPEC-treated PBS, permeabilized with DPEC-treated 0.1% Tween 20 solution (in PBS), and DPEC-treated 2 × SSC containing 0.5% Triton.…”

Section: Methodsmentioning

confidence: 99%

Transcriptomic encoding of sensorimotor transformation in the midbrain

Xie

Wang

Liu

et al. 2021

eLife

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Sensorimotor transformation, a process that converts sensory stimuli into motor actions, is critical for the brain to initiate behaviors. Although the circuitry involved in sensorimotor transformation has been well delineated, the molecular logic behind this process remains poorly understood. Here, we performed high-throughput and circuit-specific single-cell transcriptomic analyses of neurons in the superior colliculus (SC), a midbrain structure implicated in early sensorimotor transformation. We found that SC neurons in distinct laminae express discrete marker genes. Of particular interest, Cbln2 and Pitx2 are key markers that define glutamatergic projection neurons in the optic nerve (Op) and intermediate gray (InG) layers, respectively. The Cbln2+ neurons responded to visual stimuli mimicking cruising predators, while the Pitx2+ neurons encoded prey-derived vibrissal tactile cues. By forming distinct input and output connections with other brain areas, these neuronal subtypes independently mediate behaviors of predator avoidance and prey capture. Our results reveal that, in the midbrain, sensorimotor transformation for different behaviors may be performed by separate circuit modules that are molecularly defined by distinct transcriptomic codes.

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Section: Methodsmentioning

confidence: 99%

Transcriptomic encoding of sensorimotor transformation in the midbrain

Xie

Wang

Liu

et al. 2021

eLife

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“…Specifically, calcium imaging of vagal ganglia showed that GLP1R-expressing neurons are selectively activated by stomach stretch, whereas perfusion of nutrients or high osmolar solutions into the small intestine activates GPR65-expressing neurons ( Tan et al., 2020 ; Williams et al., 2016 ). Additionally, acute organ- or cell-type-specific stimulation of vagal afferents has been shown to be sufficient to alter food intake ( Bai et al., 2019 ; Chen et al., 2020 ; Han et al., 2018 ). Opto- or chemogenetic stimulation of upper-gut-innervating, GLP1R-expressing, or oxytocin-receptor-expressing vagal afferents reduced feeding ( Bai et al., 2019 ; Brierley et al., 2021 ; Han et al., 2018 ), whereas chemogenetically stimulating vagal afferents that synaptically engage tyrosine-hydroxylase-expressing neurons in the nucleus of the solitary tract (NTS) increased feeding ( Chen et al., 2020 ).…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, acute organ- or cell-type-specific stimulation of vagal afferents has been shown to be sufficient to alter food intake ( Bai et al., 2019 ; Chen et al., 2020 ; Han et al., 2018 ). Opto- or chemogenetic stimulation of upper-gut-innervating, GLP1R-expressing, or oxytocin-receptor-expressing vagal afferents reduced feeding ( Bai et al., 2019 ; Brierley et al., 2021 ; Han et al., 2018 ), whereas chemogenetically stimulating vagal afferents that synaptically engage tyrosine-hydroxylase-expressing neurons in the nucleus of the solitary tract (NTS) increased feeding ( Chen et al., 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism

et al. 2021

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“…Thus, there is now evidence implicating vagal afferents in the appetite (preference and acceptance) conditioning actions of sugar, fat, and glutamate in the gut. Interestingly, other recent findings implicate vagal afferents in the hunger state induced by fasting [ 125 , 126 ]. In one study, selective ghrelin receptor (GHSR) knockdown in vagal afferent neurons abrogated the hyperphagic effect of ghrelin administered at dark onset and caused other behavioral and metabolic impairments [ 126 ].…”

Section: Mechanisms For Protein-conditioned Preferencesmentioning

confidence: 99%

Learning of food preferences: mechanisms and implications for obesity & metabolic diseases

et al. 2021

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Omnivores, including rodents and humans, compose their diets from a wide variety of potential foods. Beyond the guidance of a few basic orosensory biases such as attraction to sweet and avoidance of bitter, they have limited innate dietary knowledge and must learn to prefer foods based on their flavors and postoral effects. This review focuses on postoral nutrient sensing and signaling as an essential part of the reward system that shapes preferences for the associated flavors of foods. We discuss the extensive array of sensors in the gastrointestinal system and the vagal pathways conveying information about ingested nutrients to the brain. Earlier studies of vagal contributions were limited by nonselective methods that could not easily distinguish the contributions of subsets of vagal afferents. Recent advances in technique have generated substantial new details on sugar- and fat-responsive signaling pathways. We explain methods for conditioning flavor preferences and their use in evaluating gut–brain communication. The SGLT1 intestinal sugar sensor is important in sugar conditioning; the critical sensors for fat are less certain, though GPR40 and 120 fatty acid sensors have been implicated. Ongoing work points to particular vagal pathways to brain reward areas. An implication for obesity treatment is that bariatric surgery may alter vagal function.

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A Vagal-NTS Neural Pathway that Stimulates Feeding

Cited by 86 publications

References 54 publications

Transcriptomic encoding of sensorimotor transformation in the midbrain

Transcriptomic encoding of sensorimotor transformation in the midbrain

Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism

Learning of food preferences: mechanisms and implications for obesity & metabolic diseases

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