A Vaccination Strategy for the Long-Term Suppression of Androgens in Advanced Prostate Cancer

Parkinson, Richard; Simms, Matthew; Broome, P.; Humphreys, Jane; Bishop, M. C.

doi:10.1016/j.eururo.2003.10.007

Cited by 22 publications

(9 citation statements)

References 10 publications

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“…Active immunization with LHRH-6-D-lysine-DT vaccine was effective for lowering of testosterone and PSA in clinical trials conducted on 28 patients of carcinoma of prostate in India and Austria (17). The utility of GnRH-DT vaccine in treatment of such patients is also reported by others (18,19).…”

Section: Introductionmentioning

confidence: 60%

Development of a novel recombinant LHRH fusion protein for therapy of androgen and estrogen dependent cancers

Gupta¹,

Hada²,

Sahai

et al. 2017

Protein Expression and Purification

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Section: Introductionmentioning

confidence: 60%

Development of a novel recombinant LHRH fusion protein for therapy of androgen and estrogen dependent cancers

Gupta¹,

Hada²,

Sahai

et al. 2017

Protein Expression and Purification

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“…Results from another Phase I study were further reported [83], where two lower vaccine doses were tested (3 and 15 ug). No responses were observed in the group treated with the lower dose, while 2 of 6 subjects in the higher dose group showed significant anti-GnRH antibody titers together with suppression of testosterone to castration levels, and with a significant and prolonged reduction in PSA.…”

Section: Cancer Vaccines Targeting the Hormone Lhrh/gnrhmentioning

confidence: 88%

Cancer Vaccines for Hormone/Growth Factor Immune Deprivation:A Feasible Approach for Cancer Treatment

Gonzalez

Lage

2007

CCDT

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One of the older and most validated cancer treatments is endocrine therapy. Some tumors are dependent on hormone stimulation for growth, and therefore therapeutic interventions aiming to deprive the cells of the hormone are feasible and have been successful. Tumor growth also depends in some cases on growth factors, so that the concept of hormone-dependence can be extended to growth factors deprivation. Hormone deprivation has been therapeutically achieved up to now by surgical, radiation and chemical means. However, the immune system usually can be manipulated to recognize hormones and growth factors, and in fact some autoimmune diseases exists involving autoantibodies against hormones. The idea of inducing a deprivation of hormones and growth factors by active immunizations is appealing, and initial evidence about the feasibility of this approach is starting to appear in the literature. Clinical trials have been initiated using immunization with human chorionic gonadotrophin (hCG), gastrin, luteinizing hormone releasing hormone (LHRH) / gonadotropin releasing hormone (GnRH) and epidermal growth factor (EGF). Preliminary data already show that antibody titers can be elicited, which results in a decrease in the concentration of a given hormone or growth factor. Both the antibody titers and the decrease in the hormone level are related to survival. This immunological approach for hormone and growth factor deprivation creates the possibility of chronic management of advanced cancer patients.

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“…Therefore, GnRH-based vaccine has good application in meat-producing industry and provides a humane treatment alternative to surgical castration [8]. Immunization of human subjects of prostate cancer with GnRH-based vaccine led to significant reduction in serum testosterone and prostate-specific antigen, with improvement in clinical parameters [15,16].…”

Section: Gonadotropin-releasing Hormonementioning

confidence: 99%

Vaccines for immunological control of fertility

Gupta

Bansal

2009

Reprod Medicine & Biology

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Vaccines have been proposed as one of the strategies for population control. Immunocontraceptive vaccines can be designed to inhibit: (1) production of gametes (sperm and egg); (2) functions of gametes, leading to blocking of fertilization; and (3) gamete outcome (pregnancy). Immunization with gonadotropin-releasing hormone coupled to different carriers has shown curtailment in the production of sperm with concomitant infertility in various species. Immunization of nonhuman primates and men with ovine follicle stimulating hormone has also resulted in reduced sperm output. Various spermatozoa-specific proteins such as FA1, PH-20, LDH-C, SP-10, SP-17, sp56, SPAG9, and Izumo have been proposed as candidate antigens to develop contraceptive vaccines, which have shown efficacy in inhibiting fertility in different animal models. Immunization with zona pellucida glycoproteins-based immunogens also results in curtailment of fertility in a variety of species. However, ways to overcome the observed oophoritis associated with zona proteins immunization have yet to be discovered, a necessary step before their proposal for control of human population. Nonetheless, this is a very promising approach to control wildlife animal population. Phase II clinical trials of β-human chorionic gonadotropin-based vaccine in women have established the proof of principle that it is possible to inhibit fertility without any untoward side-effects by vaccination. Further scientific inputs are required to increase the efficacy of contraceptive vaccines and establish their safety beyond doubt, before they can become applicable for control of fertility in humans.

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A Vaccination Strategy for the Long-Term Suppression of Androgens in Advanced Prostate Cancer

Cited by 22 publications

References 10 publications

Development of a novel recombinant LHRH fusion protein for therapy of androgen and estrogen dependent cancers

Development of a novel recombinant LHRH fusion protein for therapy of androgen and estrogen dependent cancers

Cancer Vaccines for Hormone/Growth Factor Immune Deprivation:A Feasible Approach for Cancer Treatment

Vaccines for immunological control of fertility

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