A V1-like receptor mediates vasopressin-induced flank marking behavior in hamster hypothalamus

Albers, H. Elliott; Pollock, Jennifer S.; Simmons, W H; Ferris, C. F.

doi:10.1523/jneurosci.06-07-02085.1986

Cited by 110 publications

(45 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, since the antagonist inhibited paternal activities, it is not simple to distinguish between the intrinsic effects of the antagonist and a specific blockade of the effects of injected AVP. Therefore, the pharmacological characteristics of the effects of AVP on paternal activities have to be studied in more detail, as was done for the effects of AVP on flank marking in hamsters (24,25). The effects of the injections of AVP and its antagonist suggest that endogenous as well as exogenous AVP can influence all of the prominent paternal activities except for pup retrieval.…”

Section: Discussionmentioning

confidence: 99%

Role of septal vasopressin innervation in paternal behavior in prairie voles (Microtus ochrogaster).

Wang

Ferris

Vries

1994

Proc. Natl. Acad. Sci. U.S.A.

335

213

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Role of septal vasopressin innervation in paternal behavior in prairie voles (Microtus ochrogaster).

Wang

Ferris

Vries

1994

Proc. Natl. Acad. Sci. U.S.A.

335

213

View full text Add to dashboard Cite

show abstract

“…Vasopressin is a neurotransmitter critical to the activation of flank marking, a stereotyped motor behavior used by hamsters to disseminate odors in the environment (Johnston, 1975;Ferris et al, 1984). Injecting AVP into the AH triggers intense flank marking behavior (Ferris et al, 1984), whereas blocking the V 1A receptor in this site inhibits flank marking induced by odors and agonistic encounters (Ferris et al, 1985(Ferris et al, , 1986aAlbers et al, 1986). The present studies were designed to test the hypothesis that 5-HT diminishes aggression by inhibiting the activity of the AVP system at the level of AH.…”

Section: Behavioral Assays and Drug Treatmentsmentioning

confidence: 99%

Vasopressin/Serotonin Interactions in the Anterior Hypothalamus Control Aggressive Behavior in Golden Hamsters

et al. 1997

View full text Add to dashboard Cite

Studies in several species of rodents show that arginine vasopressin (AVP) acting through a V 1A receptor facilitates offensive aggression, i.e., the initiation of attacks and bites, whereas serotonin (5-HT) acting through a 5-HT 1B receptor inhibits aggressive responding. One area of the CNS that seems critical for the organization of aggressive behavior is the basolateral hypothalamus, particularly the anterior hypothalamic region. The present studies examine the neuroanatomical and neurochemical interaction between AVP and 5-HT at the level of the anterior hypothalamus (AH) in the control of offensive aggression in Syrian golden hamsters. First, specific V 1A and 5-HT 1B binding sites in the AH are shown by in vitro receptor autoradiography. The binding for each neurotransmitter colocalizes with a dense field of immunoreactive AVP and 5-HT fibers and putative terminals. Putative 5-HT synapses on AVP neurons in the area of the AH are identified by double-staining immunocytochemistry and laser scanning confocal microscopy. These morphological data predispose a functional interaction between AVP and 5-HT at the level of the AH. When tested for offensive aggression in a resident /intruder paradigm, resident hamsters treated with fluoxetine, a selective 5-HT reuptake inhibitor, have significantly longer latencies to bite and bite fewer times than vehicle-treated controls. Conversely, AVP microinjections into the AH significantly shorten the latency to bite and increase biting attacks. The action of microinjected AVP to increase offensive aggression is blocked by the pretreatment of hamsters with fluoxetine. These data suggest that 5-HT inhibits fighting, in part, by antagonizing the aggressionpromoting action of the AVP system. Two neurotransmitter systems implicated in the control of aggressive behavior are arginine vasopressin (AVP) and serotonin (5-HT). AVP is a neurochemical signal affecting numerous brain functions (DeWied, 1971;Cooper et al., 1979;Pittman et al., 1982;Fehm-Wolfsdorf et al., 1988;Dantzer and Bluthe, 1992), including aggression (Ferris and Potegal, 1988, Koolhaas et al., 1990Potegal and Ferris, 1990;Winslow et al., 1993; Delville et al., 1996a,b). For example, microinjection of AVP V 1A -receptor antagonist into the anterior hypothalamus (AH) of a hamster causes a dose-dependent inhibition of offensive aggression, i.e., initiated attacks and bites toward a conspecific placed into their home cage (Ferris and Potegal, 1988). Similarly, AVP receptor blockade in the AH significantly reduces aggression between hamsters paired together in a neutral arena .Although AVP facilitates offensive aggression, 5-HT is reported to have the opposite effect and diminishes aggressive behavior (for review, see Olivier and Mos, 1990). For example, rats show an increase in offensive aggression after treatment with neurotoxins that deplete 5-HT levels in the hypothalamus (Vergnes et al., 1988). Conversely, rats treated with eltoprazine, a 5-HT 1 receptor agonist, show a dose-dependent decrease in offensive aggressi...

show abstract

“…Flank marking is a form of social communication in which hamsters deposit flank gland secretions by rubbing their flank glands against objects in the environment (Johnston and Brenner, 1982; Johnston and Lee, 1976). Studies of flank marking have not only provided an important window into the mechanisms underlying the control of social behavior by AVP (Ferris et al, 2013), they have also proven to be a powerful bioassay for the behavioral effects of AVP/OT agonists and antagonists in the brain (Albers et al, 1986; Ferris et al, 1988). In the following studies we tested the hypothesis that OT can influence flank marking by acting on V1a receptors.…”

Section: Introductionmentioning

confidence: 99%

Oxytocin induces social communication by activating arginine-vasopressin V1a receptors and not oxytocin receptors

Song

McCann

McNeill

et al. 2014

Psychoneuroendocrinology

101

View full text Add to dashboard Cite

Arginine-vasopressin (AVP) and oxytocin (OT) and their receptors are very similar in structure. As a result, at least some of the effects of these peptides may be the result of crosstalk between their canonical receptors. The present study investigated this hypothesis by determining whether the induction of flank marking, a form of social communication in Syrian hamsters, by OT is mediated by the OT receptor or the AVP V1a receptor. Intracerebroventricular (ICV) injections of OT or AVP induced flank marking in a dose-dependent manner although the effects of AVP were approximately 100 times greater than those of OT. Injections of highly selective V1a receptor agonists but not OT receptor agonists induced flank marking, and V1a receptor antagonists but not OT receptor antagonists significantly inhibited the ability of OT to induce flank marking. Lastly, injection of alpha-melanocyte-stimulating hormone (α-MSH), a peptide that stimulates OT but not AVP release, significantly increased odor-induced flank marking, and these effects were blocked by a V1a receptor antagonist. These data demonstrate that OT induces flank marking by activating AVP V1a and not OT receptors, suggesting that the V1a receptor should be considered to be an OT receptor as well as an AVP receptor.

show abstract

A V1-like receptor mediates vasopressin-induced flank marking behavior in hamster hypothalamus

Cited by 110 publications

References 32 publications

Role of septal vasopressin innervation in paternal behavior in prairie voles (Microtus ochrogaster).

Role of septal vasopressin innervation in paternal behavior in prairie voles (Microtus ochrogaster).

Vasopressin/Serotonin Interactions in the Anterior Hypothalamus Control Aggressive Behavior in Golden Hamsters

Oxytocin induces social communication by activating arginine-vasopressin V1a receptors and not oxytocin receptors

Contact Info

Product

Resources

About