A urine inhibitor of interleukin 1 activity affects both interleukin 1 alpha and 1 beta but not tumor necrosis factor alpha.

Seckinger, P; Williamson, K; Balavoine, Jean-François; Mach, Bernard; Mazzei, Gonzalo J.; Shaw, Alan; Jm, Dayer

doi:10.4049/jimmunol.139.5.1541

Cited by 125 publications

(2 citation statements)

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“…The activity of both forms of IL-1 is antagonized by IL-l-receptor antagonist protein (IRAP) [40]. IRAP is a specific antagonist that competitively inhibits binding of IL-1 to its receptors but which has no intrinsic agonist activity [8,11,35].…”

Section: Introductionmentioning

confidence: 99%

Synovial fluid cytokine concentrations as possible prognostic indicators in the ACL-deficient knee

Cameron

Paessler³

et al. 1994

Knee Surg, Sports traumatol, Arthroscopy

138

101

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Approximately 44% of patients develop osteoarthritis (OA) following rupture of the anterior cruciate ligament (ACL) if the injury is left unrepaired. Restoring knee stability through reconstruction, while providing symptomatic relief, has not been shown to reduce the incidence of degenerative changes. In fact, recent studies have shown that 50%-60% of ACL-reconstructed patients go on to develop degenerative changes or frank osteoarthritis. In light of these data, our group suggests that the cause of post-traumatic osteoarthritis is not biomechanical but biochemical. To test this hypothesis, we measured levels of nine cytokines which are important in modulating physiological and pathophysiological metabolism of cartilage in knee joint synovial fluid following ACL rupture. Our patient population contained both acute and chronic ACL ruptures. A total of 84 samples were collected and analyzed by enzyme-linked immunosorbent assay. On the basis of the data collected, we were able to identify subgroups of patients who, on the basis of their synovial fluid cytokine profile, may be at greater or lesser risk of developing post-traumatic OA. In general, patients displayed concentrations of interleukin-1 alpha (IL-1 alpha), basic fibroblastic growth factor (bFGF), transforming growth factor-beta (TGF-beta), granulocyte/macrophage-colony stimulating factor (GM-CSF), IL-6, and IL-8 that we interpreted as being consistent with an inflammatory reaction. Of great interest is the fact that the levels of these cytokines were very similar in patients 4 weeks after injury and in chronic patients, leading us to hypothesize that a chronic smoldering inflammatory reaction persists after resolution of the acute effusion.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Introductionmentioning

confidence: 99%

Synovial fluid cytokine concentrations as possible prognostic indicators in the ACL-deficient knee

Cameron

Paessler³

et al. 1994

Knee Surg, Sports traumatol, Arthroscopy

138

101

View full text Add to dashboard Cite

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“…The initial n-3 PUFA-dependent increase in basal levels of IL-1ra in CR KO mice may be related to microglial RvE1 expression. It is uncertain why this effect was limited to the CR KO mice in our study, but an early production of IL-1ra, such as from microglia [136] could limit LPS-induced inflammation through reduced emigration of neutrophils [137] and modulation of IL-1β pro-inflammatory activity [136,138,139]. To expand on our present mRNA expression data, further analysis is required to confirm the potential role of Rv signaling for brain IL-1β/IL-1ra action on protein levels.…”

Section: Discussionmentioning

confidence: 83%

n-3 Polyunsaturated Fatty Acids Modulate LPS-Induced ARDS and the Lung–Brain Axis of Communication in Wild-Type versus Fat-1 Mice Genetically Modified for Leukotriene B4 Receptor 1 or Chemerin Receptor 23 Knockout

Hernandez,

Schäffer,

Herden

et al. 2023

IJMS

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Specialized pro-resolving mediators (SPMs) and especially Resolvin E1 (RvE1) can actively terminate inflammation and promote healing during lung diseases such as acute respiratory distress syndrome (ARDS). Although ARDS primarily affects the lung, many ARDS patients also develop neurocognitive impairments. To investigate the connection between the lung and brain during ARDS and the therapeutic potential of SPMs and its derivatives, fat-1 mice were crossbred with RvE1 receptor knockout mice. ARDS was induced in these mice by intratracheal application of lipopolysaccharide (LPS, 10 µg). Mice were sacrificed at 0 h, 4 h, 24 h, 72 h, and 120 h post inflammation, and effects on the lung, liver, and brain were assessed by RT-PCR, multiplex, immunohistochemistry, Western blot, and LC-MS/MS. Protein and mRNA analyses of the lung, liver, and hypothalamus revealed LPS-induced lung inflammation increased inflammatory signaling in the hypothalamus despite low signaling in the periphery. Neutrophil recruitment in different brain structures was determined by immunohistochemical staining. Overall, we showed that immune cell trafficking to the brain contributed to immune-to-brain communication during ARDS rather than cytokines. Deficiency in RvE1 receptors and enhanced omega-3 polyunsaturated fatty acid levels (fat-1 mice) affect lung–brain interaction during ARDS by altering profiles of several inflammatory and lipid mediators and glial activity markers.

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The Relationship Among Obesity, Inflammation, and Insulin Resistance

Bastard¹,

Fève²

2013

Metabolic Syndrome and Neurological Disorders

311

365

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A urine inhibitor of interleukin 1 activity affects both interleukin 1 alpha and 1 beta but not tumor necrosis factor alpha.

Cited by 125 publications

References 0 publications

Synovial fluid cytokine concentrations as possible prognostic indicators in the ACL-deficient knee

Synovial fluid cytokine concentrations as possible prognostic indicators in the ACL-deficient knee

n-3 Polyunsaturated Fatty Acids Modulate LPS-Induced ARDS and the Lung–Brain Axis of Communication in Wild-Type versus Fat-1 Mice Genetically Modified for Leukotriene B4 Receptor 1 or Chemerin Receptor 23 Knockout

The Relationship Among Obesity, Inflammation, and Insulin Resistance

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