A universal bacterial sensor created by integrating a light modulating aptamer complex with photoelectrochemical signal readout

Bakhshandeh, Fatemeh; Saha, Sudip; Sen, Payel; Sakib, Sadman; Maclachlan, Roderick; Kanji, Farhaan; Osman, Enas; Soleymani, Leyla

doi:10.1016/j.bios.2023.115359

Cited by 5 publications

(3 citation statements)

References 70 publications

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“…One of the early examples of aptasensors was developed for detecting thrombin, where a conformational change in the redox-labelled thrombinbound aptamer enabled detection. 158 Over the past twenty years, numerous aptamers have been selected and incorporated into electrochemical assays for detecting different classes of targets, including small molecules (e.g., glucose, adenosine), [159][160][161][162] nucleic acids, 146,163 proteins (e.g., infectious agents, hormones, receptors), 147,[164][165][166][167][168][169] extracellular vesicles, 170,171 and cancer cells. 172,173 Even though such advancements are promising, the degradation of aptamers by nucleases in biological samples is an ongoing concern.…”

Section: Biorecognition Elements and Sensor Functionalizationmentioning

confidence: 99%

Editors’ Choice—Challenges and Opportunities for Developing Electrochemical Biosensors with Commercialization Potential in the Point-of-Care Diagnostics Market

Akhlaghi,

Kaur,

Adhikari

et al. 2024

ECS Sens. Plus

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There is a plethora of electrochemical biosensors developed for ultrasensitive detection of clinically-relevant biomarkers. However, many of these systems lose their performance in heterogeneous clinical samples and are too complex to be operated by end users at the point-of-care (POC), prohibiting their commercial success. Integration of biosensors with sample processing technology addresses both of these challenges; however, it adds to the manufacturing complexity and the overall cost of these systems. Herein, we review the different components of a biosensor and avenues for creating fully-integrated systems. In the context of integration, we focus on discussing the trade-offs between sensing performance, cost, and scalable manufacturing to guide the readers toward designing new electrochemical biosensors with commercialization potential.

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Section: Biorecognition Elements and Sensor Functionalizationmentioning

confidence: 99%

Editors’ Choice—Challenges and Opportunities for Developing Electrochemical Biosensors with Commercialization Potential in the Point-of-Care Diagnostics Market

Akhlaghi,

Kaur,

Adhikari

et al. 2024

ECS Sens. Plus

Self Cite

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“…The continual expansion in photoactive materials and sensing strategies has significantly propelled the rapid progress in PEC analysis [14][15][16][17]. As a result of these advancements, numerous PEC sensing platforms have been successfully established and applied for detecting various analytes, including ions [18], small molecules [19][20][21][22][23][24][25], biomacromolecules [26][27][28][29], cells [30][31][32][33], microorganisms [34][35][36][37], and in vivo detection [38][39][40].…”

Section: Introductionmentioning

confidence: 99%

“…The continual expansion in photoactive materials and sensing strategies has significantly propelled the rapid progress in PEC analysis [14–17]. As a result of these advancements, numerous PEC sensing platforms have been successfully established and applied for detecting various analytes, including ions [18], small molecules [19–25], biomacromolecules [26–29], cells [30–33], microorganisms [34–37], and in vivo detection [38–40]. A number of key reviews have comprehensively summarized significant research advancements in PEC detection, covering topics such as photoactive materials [13, 28, 41–52], sensing modalities [53–58], and target analytes [37, 59–64].…”

Section: Introductionmentioning

confidence: 99%