A Universal and Versatile Approach for Surface Biofunctionalization: Layer‐by‐Layer Assembly Meets Host–Guest Chemistry

Cao, Limin; Qu, Yangcui; Hu, Chang‐Ming; Wei, Ting; Zhan, Wenjun; Yu, Qian; Chen, Hong

doi:10.1002/admi.201600600

Cited by 47 publications

(42 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tecothane (TT-1095A) polyurethane (PU) was from Thermedics (Wilmington, MA, USA) and was purified by Soxhlet extraction with methanol, toluene and methanol each for 48 h. 6-amino-2-(2-methacylamido)-hexanoic acid (LysMA), 17 6-(4sulfonylmethyl-1H-[1,2,3]triazol-1-yl)-6-deoxy-β-cyclodextrin (CD-S) 18 , AdaMA 19 and fluorescein isothiocyanate modified βcyclodextrin (CD-FITC) 20 were prepared as described previously. 2, 2'-Azoisobutyronitrile (AIBN) from Tokyo Chemical Industry Company was recrystallized from methanol solution and dried under vacuum.…”

Section: Methodsmentioning

confidence: 99%

A multifunctional surface for blood contact with fibrinolytic activity, ability to promote endothelial cell adhesion and inhibit smooth muscle cell adhesion

Chen

et al. 2017

J. Mater. Chem. B

Self Cite

View full text Add to dashboard Cite

Blood compatible materials are required for a wide variety of medical devices. Despite many years of intensive effort, however, the blood compatibility problem, in particular the ability to prevent thrombosis, remains unsolved. Based on the knowledge that the vascular endothelium, the ultimate blood contacting surface, draws on several mechanisms to maintain blood fluidity, it seems reasonable that analogous multifunctionality should be the goal for blood compatible biomaterials.In the present work, a polyurethane surface was modified with the terpolymer poly(2-hydroxyethyl methacrylate-co-6amino-2-(2-methacylamido)-hexanoic acid-co-1-adamantan-1-yl methyl methacrylate) (poly(HEMA-co-LysMA-co-AdaMA)), referred to as PU-PHLA. Poly(HEMA) and poly(LysMA) were intended to provide, respectively, resistance to non-specific protein adsorption and the ability to lyse incipient clots. The heparin-like moiety, sulfonated β-cyclodextrin was immobilized on the PU-PHLA via host-guest interactions with the poly(AdaMA). This component is expected to inhibit coagulation and smooth muscle cell proliferation and to promote endothelialization. The resulting materials were shown to have multifunctionalities including fibrinolytic activity, anticoagulant activity and the ability to promote endothelial cell adhesion and inhibit smooth muscle cell adhesion. This work provides a new strategy for the development of multifunctional, endothelial-mimicking, biomaterials for blood contacting applications.

show abstract

Section: Methodsmentioning

confidence: 99%

A multifunctional surface for blood contact with fibrinolytic activity, ability to promote endothelial cell adhesion and inhibit smooth muscle cell adhesion

Chen

et al. 2017

J. Mater. Chem. B

Self Cite

View full text Add to dashboard Cite

show abstract

“…To overcome this limitation, we proposed an effective approach to realize surface regeneration by simultaneously releasing inactive biocides together with dead bacteria through immobilization of biocides to the surface in a reversible way using noncovalent interactions (such as host–guest interactions and dynamic covalent bonds). To this end, we designed a multivalent biocidal compound named CD‐QAS, which was synthesized by conjugation of seven QAS groups to the primary hydroxyl groups on the narrow rim of β‐cyclodextrin (β‐CD) via click chemistry . As shown in Figure a, the unique chemical structure of CD‐QAS possesses several advantages to make it suitable for the fabrication of regenerable smart antibacterial coatings: i) seven QAS groups on the narrow rim increase the local density of biocidal groups and thus enhance the antibacterial activity due to multivalent effect; ii) the hydrophobic cavity is suitable for the inclusion of guest molecules such as adamantine (Ada) and azobenzene (Azo) via supramolecular host–guest interaction; and iii) the secondary hydroxyl groups on the wide rim exhibit diol structure that can bind to phenylboronic acid (PBA) groups via sugar/pH‐responsive dynamic boronate ester bonds.…”

Section: Smart “Kill‐and‐release” Antibacterial Coatingsmentioning

confidence: 99%

“…Moreover, in this system, it is facile to incorporate another functional β‐CD derivative together with CD‐QAS on the surface to realize dual functions. In two proof‐of‐concept demonstrations, β‐CD decorated with lysine (which can specifically bind plasminogen to realize fibrinolytic activity)[104a] or Arg–Glu–Asp–Val peptide (which can promote the adhesion and proliferation of endothelial cells) was co‐incorporated with CD‐QAS. It is found that the resulting surfaces exhibited both specific bioactivity and antibacterial ability; these two functions were not compromised by the presence of the other .…”

Section: Smart “Kill‐and‐release” Antibacterial Coatingsmentioning

confidence: 99%

“…It is found that the resulting surfaces exhibited both specific bioactivity and antibacterial ability; these two functions were not compromised by the presence of the other . Moreover, because the LBL deposition can be performed on almost all kinds of substrates and both LBL assembly and the incorporation of CD‐QAS can be conducted under mild conditions,[104a,114] this method offers a versatile and universal approach for fabrication of smart antibacterial coatings.…”

Section: Smart “Kill‐and‐release” Antibacterial Coatingsmentioning

confidence: 99%

See 1 more Smart Citation

Responsive and Synergistic Antibacterial Coatings: Fighting against Bacteria in a Smart and Effective Way

Wei

Chen

2019

Adv Healthcare Materials

Self Cite

302

207

View full text Add to dashboard Cite

Antibacterial coatings that eliminate initial bacterial attachment and prevent subsequent biofilm formation are essential in a number of applications, especially implanted medical devices. Although various approaches, including bacteria‐repelling and bacteria‐killing mechanisms, have been developed, none of them have been entirely successful due to their inherent drawbacks. In recent years, antibacterial coatings that are responsive to the bacterial microenvironment, that possess two or more killing mechanisms, or that have triggered‐cleaning capability have emerged as promising solutions for bacterial infection and contamination problems. This review focuses on recent progress on three types of such responsive and synergistic antibacterial coatings, including i) self‐defensive antibacterial coatings, which can “turn on” biocidal activity in response to a bacteria‐containing microenvironment; ii) synergistic antibacterial coatings, which possess two or more killing mechanisms that interact synergistically to reinforce each other; and iii) smart “kill‐and‐release” antibacterial coatings, which can switch functionality between bacteria killing and bacteria releasing under a proper stimulus. The design principles and potential applications of these coatings are discussed and a brief perspective on remaining challenges and future research directions is presented.

show abstract

“…In this regard, surface functionalization represents one of the straightforward and effective methods to endow biomaterials with excellent properties and functions [5,6]. According to the mechanism of the interaction between the implant and the surrounding physiological environment, the introduction of bioactive factors on the surface by physical or chemical conjugation can endow the inert biomaterial with good biological activities, so as to regulate the cellmaterial interaction behaviors, induce speci c cell responses, and prevent the infection caused by implantation and related biological effects [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Assembly of Gentamicin and Zn2+ Loaded Coatings on TiO2 Nanotubes to Synergistically Improve the Blood Compatibility, Endothelial Cell Growth and Antibacterial Activities

Pan

Yang

et al. 2020

Preprint

View full text Add to dashboard Cite

Titanium and its alloys are widely used in blood contacting implantable and interventional medical devices; however, their biocompatibility is still facing great challenges. In this study, with the aim of improving the biocompatibility and antibacterial activities of titanium, TiO2 nanotubes with a diameter of about 30 nm were firstly prepared on the titanium surface by anodization, followed by the introduction of polyacrylic acid (PAA) and gentamicin (GS) on the nanotube surface by layer-by-layer method, and finally zinc ions were loaded into the surface to improve the bioactivities. The nanotubes have excellent hydrophilic properties and special nanotube-like structure, which can selectively promote the albumin adsorption and enhance the blood compatibility and promote the growth and functional expression of endothelial cells to a certain extent. After the introduction of PAA and GS, although the super-hydrophilicity cannot be achieved, the results of platelet adhesion, cGMP activity, hemolysis rate and partial thromboplastin time (APTT) showed that the blood compatibility was improved, and the blood compatibility was further enhanced after zinc ions loading on the surface. On the other hand, the surface modified materials showed good cytocompatibility to endothelial cells. The introduction of PAA and zinc ions not only promoted the adhesion and proliferation of endothelial cells, but also up-regulated expression of vascular endothelial growth factor (VEGF) and nitric oxide (NO). The slow and continuous release of GS and Zn2+ for more than 14 days, which can significantly improve the antibacterial properties of the materials. Therefore, the present study provides an effective method for the surface modification of titanium-based blood-contacting materials to simultaneously endow with good blood compatibility, endothelial growth behaviors and antibacterial properties.

show abstract

A Universal and Versatile Approach for Surface Biofunctionalization: Layer‐by‐Layer Assembly Meets Host–Guest Chemistry

Cited by 47 publications

References 56 publications

A multifunctional surface for blood contact with fibrinolytic activity, ability to promote endothelial cell adhesion and inhibit smooth muscle cell adhesion

A multifunctional surface for blood contact with fibrinolytic activity, ability to promote endothelial cell adhesion and inhibit smooth muscle cell adhesion

Responsive and Synergistic Antibacterial Coatings: Fighting against Bacteria in a Smart and Effective Way

Assembly of Gentamicin and Zn2+ Loaded Coatings on TiO2 Nanotubes to Synergistically Improve the Blood Compatibility, Endothelial Cell Growth and Antibacterial Activities

Contact Info

Product

Resources

About