A unique structural distribution pattern discovered for the cerebrosides from starfish Asterias amurensis

Yamaguchi, Ryosuke; Kanie, Yoshimi; Kanie, Osamu; Shimizu, Yoshitaka

doi:10.1016/j.carres.2018.12.013

Cited by 6 publications

(3 citation statements)

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“…The compound has also been reported to have activity useful in the management of Alzheimer's and Parkinson's diseases. Certain marine compounds can be further synthesized through this molecule to produce more specific biological effects [76][77][78] (Tables 4 and 5), Figure 2.…”

Section: Conflicts Of Interestmentioning

confidence: 99%

Natural Products for Chronic Diseases: A Ray of Hope

2023

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Section: Conflicts Of Interestmentioning

confidence: 99%

Natural Products for Chronic Diseases: A Ray of Hope

2023

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“…The FA contained in cerebrosides from sea cucumbers is similar to those of common mammals, although it has more double bonds and hydroxylation. The study of the cerebroside composition of the gonads, viscera, and whole body of the starfish Asterias amurensis revealed a characteristic structure distribution that can be divided into three major structural groups [ 146 ].…”

Section: Ms-based Metabolomic Profiling Approaches To the Study Of St...mentioning

confidence: 99%

Application of MS-Based Metabolomic Approaches in Analysis of Starfish and Sea Cucumber Bioactive Compounds

2022

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Today, marine natural products are considered one of the main sources of compounds for drug development. Starfish and sea cucumbers are potential sources of natural products of pharmaceutical interest. Among their metabolites, polar steroids, triterpene glycosides, and polar lipids have attracted a great deal of attention; however, studying these compounds by conventional methods is challenging. The application of modern MS-based approaches can help to obtain valuable information about such compounds. This review provides an up-to-date overview of MS-based applications for starfish and sea cucumber bioactive compounds analysis. While describing most characteristic features of MS-based approaches in the context of starfish and sea cucumber metabolites, including sample preparation and MS analysis steps, the present paper mainly focuses on the application of MS-based metabolic profiling of polar steroid compounds, triterpene glycosides, and lipids. The application of MS in metabolomics studies is also outlined.

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“…The compound has also been reported to have activity useful in the management of Alzheimer’s and Parkinson’s diseases. Certain marine compounds can be further synthesized through this molecule to produce more specific biological effects [ 76 , 77 , 78 ] ( Table 4 and Table 5 ), Figure 2 .…”

Section: Marine Drugs In Neurodegenerationmentioning

confidence: 99%

Biotechnological Innovations from Ocean: Transpiring Role of Marine Drugs in Management of Chronic Disorders

et al. 2022

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Marine drugs are abundant in number, comprise of a diverse range of structures with corresponding mechanisms of action, and hold promise for the discovery of new and better treatment approaches for the management of several chronic diseases. There are huge reserves of natural marine biological compounds, as 70 percent of the Earth is covered with oceans, indicating a diversity of chemical entities on the planet. The marine ecosystems are a rich source of bioactive products and have been explored for lead drug molecules that have proven to be novel therapeutic targets. Over the last 70 years, many structurally diverse drug products and their secondary metabolites have been isolated from marine sources. The drugs obtained from marine sources have displayed an exceptional potential in the management of a wide array of diseases, ranging from acute to chronic conditions. A beneficial role of marine drugs in human health has been recently proposed. The current review highlights various marine drugs and their compounds and role in the management of chronic diseases such as cancer, diabetes, neurodegenerative diseases, and cardiovascular disorders, which has led to the development of new drug treatment approaches.

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A unique structural distribution pattern discovered for the cerebrosides from starfish Asterias amurensis

Cited by 6 publications

References 45 publications

Natural Products for Chronic Diseases: A Ray of Hope

Natural Products for Chronic Diseases: A Ray of Hope

Application of MS-Based Metabolomic Approaches in Analysis of Starfish and Sea Cucumber Bioactive Compounds

Biotechnological Innovations from Ocean: Transpiring Role of Marine Drugs in Management of Chronic Disorders

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