A unique reaction of diphenylcyclopropenone and 1,2-aminothiol with the release of thiol for multiple bioconjugation

Liu, Shanshan; Ye, Haishun; Yi, Long; Xi, Zhen

doi:10.1039/d2cc06419g

Chem. Commun.

2023

DOI: 10.1039/d2cc06419g

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A unique reaction of diphenylcyclopropenone and 1,2-aminothiol with the release of thiol for multiple bioconjugation

Shanshan Liu

Haishun Ye

Long Yi

et al.

Abstract: Selective reaction of diphenylcyclopropenone (DPCP) and 1,2-aminothiol in water at pH 7.4 produces an amide conjugate with releasing the thiol. In addition, structural modifications of DPCP enable the coupling rate...

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A unique reaction of diphenylcyclopropenone and 1,2-aminothiol with the release of thiol for multiple bioconjugation

Abstract: Selective reaction of diphenylcyclopropenone (DPCP) and 1,2-aminothiol in water at pH 7.4 produces an amide conjugate with releasing the thiol. In addition, structural modifications of DPCP enable the coupling rate...

Cited by 0 publications

References 67 publications

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