A unique fluorescence response of hexaphenylsilole to methyl parathion hydrolase: a new signal generating system for the enzyme label

Zhao, Ge; Tang, Biao; Dong, Yong Qiang; Xie, Wei; Tang, Ben Zhong

doi:10.1039/c4tb00624k

Cited by 15 publications

(5 citation statements)

References 15 publications

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Section: Technological Applicationsmentioning

confidence: 99%

“…AIE strategy has been reported to bring new hope to this area, for an effective signal generating system for MPH has been established on the basis of it (Figure 91). 548 In this reporter system for MPH, the amino-functionalized HPS, i.e., A 2 HPS (350), serves as a signaling moiety whose fluorescence can be modulated between the "on" and "off" state by stimuli, whereas MP is a substrate for MPH and also a quencher to 350. A unique fluorescence response of the ensemble towards MPH has been achieved.…”

Section: Chemical Reviewsmentioning

confidence: 99%

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Aggregation-Induced Emission: Together We Shine, United We Soar!

et al. 2015

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Section: Technological Applicationsmentioning

confidence: 99%

Section: Chemical Reviewsmentioning

confidence: 99%

Aggregation-Induced Emission: Together We Shine, United We Soar!

et al. 2015

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“…The fifth design principle involves the disruption of processes of non-radiative decay, such as photoinduced electron transfer (PET) and energy transfer (ET) (Figure E). This type of AIEgens needs to be modified with quencher groups (e.g., maleimide) or mixed with quenching species (e.g., dabcyl groups and methyl parathion) . In the very beginning, the AIEgens are nonemissive as a result of either electron or energy transfer from the AIEgens to the quencher groups, ensuring low background signals.…”

Section: Bringing Aiegens Into Biomacromolecule Sensingmentioning

confidence: 99%

Aggregation-Induced Emission: A Trailblazing Journey to the Field of Biomedicine

Zhu

Kwok

Lam

et al. 2018

ACS Appl. Bio Mater.

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The emergence of the aggregation-induced emission (AIE) concept significantly changes the cognition of the scientific community toward classic photophysical phenomena. More importantly, the AIE phenomenon has brought huge opportunities for the analysis of bioactive species, the monitoring of complicated biological processes, and the elucidation of key physiological and pathological behaviors. As a class of promising luminescent materials, AIE luminogens (AIEgens) are weakly or non-emissive in the form of isolated molecular species but emit particularly strong fluorescence in the aggregated and solid states. Motivated by the prominent advantages such as high brightness, large Stokes shift, excellent photostability, and good biocompatibility, AIEgen-based bioprobes have been widely explored in the field of biomedicine. This review aims to provide a systematic summary of the developmental history and an in-depth perspective of the current landscape of AIE in the biomedical field, with an emphasis on the discussions of major working principles. The milestones of the historical development of AIE in the biomedical field are first reviewed. A total of four major research directions are then extracted, including biomacromolecule sensing (at the molecular level), in vitro cell imaging (at the cellular level), in vivo imaging (at the animal level), and cancer theranostics (at the cellular and animal levels), together with clear-cut tables showing comprehensive cases for further study. Lastly, this review is concluded by the discussions of several perspectives on future directions. It is believed that AIEgen-based bioprobes will play vital roles in the exploration of mysterious life processes by integration with various cutting-edge modalities and techniques with an ultimate goal of addressing more healthcare issues.

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“…The detection of enzyme activity has values significant to biological research and clinical diagnosis of disease. AIE sensors have been used for detection of various enzymes, including acetylcholinesterase (AChE), alkaline phosphatase (ALP), − esterase, , caspases, − chymase, furin, β-galactosidase, , hyaluronidase, methyl parathion hydrolase (MPH), monoamine oxidases, , NAD(P)H: quinone oxidoreductase-1 (NQO1), sirtuin type 1 (SIRT1), and telomerase. , In this section, we will represent some recent examples of AIE sensors for enzyme detection.…”

Section: Biological Macromoleculesmentioning

confidence: 99%

Fluorescent Sensors Based on Aggregation-Induced Emission: Recent Advances and Perspectives

2017

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Fluorescent sensors with advantages of excellent sensitivity, rapid response, and easy operation are emerging as powerful tools in environmental monitoring, biological research, and disease diagnosis. However, conventional fluorophores featured with π-planar structures usually suffer from serious self-quenching in the aggregated state, poor photostability, and small Stokes' shift. In contrast to conventional aggregation-caused quenching (ACQ) fluorophores, the newly emerged aggregation-induced emission fluorogens (AIEgens) are featured with high emission efficiency in the aggregated state, which provide unique opportunities for various sensing applications with advantages of high signal-to-noise ratio, strong photostability, and large Stokes' shift. In this review, we will first briefly give an introduction of the AIE concept and the turn-on sensing principles. Then, we will discuss the recent examples of AIE sensors according to types of analytes. Finally, we will give a perspective on the future developments of AIE sensors. We hope this review will inspire more endeavors to devote to this emerging world.

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A unique fluorescence response of hexaphenylsilole to methyl parathion hydrolase: a new signal generating system for the enzyme label

Cited by 15 publications

References 15 publications

Aggregation-Induced Emission: Together We Shine, United We Soar!

Aggregation-Induced Emission: Together We Shine, United We Soar!

Aggregation-Induced Emission: A Trailblazing Journey to the Field of Biomedicine

Fluorescent Sensors Based on Aggregation-Induced Emission: Recent Advances and Perspectives

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