A Unique Dendritic Cell Subset Accumulates in the Celiac Lesion and Efficiently Activates Gluten-Reactive T Cells

Ráki, Melinda; Tollefsen, Stig; Molberg, Øyvind; Lundin, Knut E.A.; Sollid, Ludvig M.; Jahnsen, Frode L.

doi:10.1053/j.gastro.2006.06.002

Cited by 109 publications

(101 citation statements)

References 46 publications

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“…A unique subset of dendritic cells appears to be responsible for loc al ac tivation of glutenreac tive T-c ells in the c eliac lesion [113] . Enteric glial c ells (EGC) release neurotropic fac tors and are ac tivated by inflammatory insults.…”

Section: Alternatives To a Gluten Free Dietmentioning

confidence: 98%

Recent advances in celiac disease

Freeman

Chopra²,

Clandinin³

et al. 2011

WJG

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Celiac disease now affects about one person in a hundred in Europe and North America. In this review, we consider a number of important and exciting recent developments, such as clinical associations, HLA-DQ2 and HLA-DQ8 predispositions, the concept of potential celiac disease, the use of new imaging/endoscopy techniques, and the development of refractory disease. This review will be of use to all internists, pediatricians and gastroenterologists.

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Section: Alternatives To a Gluten Free Dietmentioning

confidence: 98%

Recent advances in celiac disease

Freeman

Chopra²,

Clandinin³

et al. 2011

WJG

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“…8B). To this regard, it is relevant that vast majority of ascribed duodenal mucosa myeloid DCs has been recently described as positive for CD11c, a typical myeloid DC marker (58), and negative for BDCA3, a marker differentially expressed on DC subsets (53,59). These results could suggest the expression of HLA-E molecule on myeloid DC resident in intestinal mucosa of untreated CD patient.…”

Section: Mononuclear Cells Expressing High Levels Of Hla-e and Cd3mentioning

confidence: 99%

Gliadin Regulates the NK-Dendritic Cell Cross-Talk by HLA-E Surface Stabilization

Terrazzano

Sica

Gianfrani

et al. 2007

The Journal of Immunology

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We analyzed the autologous NK cell interaction with gliadin-presenting dendritic cells. Gliadin is the known Ag priming the celiac disease (CD) pathogenesis. We demonstrate that gliadin prevents immature dendritic cells (iDCs) elimination by NK cells. Furthermore, cooperation between human NK cells-iDCs and T cells increases IFN-γ production of anti-gliadin immune response. Gliadin fractions were analyzed for their capability to stabilize HLA-E molecules. The α and ω fractions conferred the protection from NK cell lysis to iDCs and increased their HLA-E expression. Gliadin pancreatic enzyme digest and a peptide derived from gliadin α increased HLA-E levels on murine RMA-S/HLA-E-transfected cells. Analysis of HLA-E expression in the small intestinal mucosa of gluten-containing diet celiac patients and organ culture experiments confirmed the in vitro data.

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“…The number of myeloid DCs is elevated in active celiac mucosa compared with that in treated celiac mucosa and healthy controls, and the cells display an activated and mature phenotype (89,100). Moreover, when CD11c + DCs isolated from untreated celiac mucosa are cultured in vitro with gliadin, they are more efficient than HLA-DQ2 + macrophages in activating gliadin-reactive T cells (100).…”

Section: Figurementioning

confidence: 99%

Dendritic cells in intestinal homeostasis and disease

Rescigno¹,

Sabatino²

2009

J. Clin. Invest.

291

233

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DCs are specialized APCs that orchestrate innate and adaptive immune responses. The intestinal mucosa contains numerous DCs, which induce either protective immunity to infectious agents or tolerance to innocuous antigens, including food and commensal bacteria. Several subsets of mucosal DCs have been described that display unique functions, dictated in part by the local microenvironment. In this review, we summarize the distinct subtypes of DCs and their distribution in the gut; examine how DC dysfunction contributes to intestinal disease development, including inflammatory bowel disease and celiac disease; and discuss manipulation of DCs for therapy.

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A Unique Dendritic Cell Subset Accumulates in the Celiac Lesion and Efficiently Activates Gluten-Reactive T Cells

Cited by 109 publications

References 46 publications

Recent advances in celiac disease

Recent advances in celiac disease

Gliadin Regulates the NK-Dendritic Cell Cross-Talk by HLA-E Surface Stabilization

Dendritic cells in intestinal homeostasis and disease

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