A unique chromosome translocation, t(11;12;18)(q13;q13;q12), in primary lung lymphoma

Kubonishi, Ichiro; S, Sugito; Kobayashi, Makoto; Asahi, Yasutomo; Tsuchiya, Takayuki; Yamashiro, Toshiyuki; Miyoshi, Isao

doi:10.1016/0165-4608(94)00290-r

Cited by 17 publications

(13 citation statements)

References 14 publications

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“…The translocation t(ll;18)(q21;q21) in all reported cases (including the three-way translocation reported by Kubonoshi [18]) is almost always present as a single clonal aberration with the exception of case #3 reported here. In contrast, trisomy 3, identified as the most frequent cytogenetic abnormality associated with MALT lymphomas and present in nine of the 28 clones of the previously published cases, is accompanied by other numerical and structural karyotypic alterations in all but one case [5,[19][20][21].…”

Section: Discussionmentioning

confidence: 79%

“…Cytogenetic analysis of additional cases will be of benefit in further exploring this relationship. Histologically, the three cases reported here, as well as the case published by Leroux [16] and Kubonishi et al [18] with similar cytogenetic abnormalities were histologically classified as extranodal B-cell lymphomas of MALT type. The remaining four cases, reported by Griffin et al [15] and Levine et al [14], were diagnosed as small lymphocytic lymphoma, however the details of their histopathologic appearance are not provided in the respective reports.…”

Section: Discussionmentioning

confidence: 88%

“…The single case of primary MALT lymphoma of the lung documented by Kubonishi et al [18] revealed a three way translocation involving chromosomes 11, 12 and 18. The ISCN description of the translocation indicates breakpoints at Ilql3, 12ql3 and 18ql2, however our review of the published karyotype reveals that the der(ll) is very similar to that found in our cases of t(ll;18) and suggests that breakpoints at Ilq21 and 18q21 may be involved.…”

Section: Discussionmentioning

confidence: 99%

“…We have identified three cases of recurrent t(ll;18)(q21;q21), one of which had been previously published as a single case report [10]. Six additional cases with t(ll;18) were extracted from the literature [14][15][16]18]. All nine cases share similar cyto- [7]/46,XY [15] 46,XX,t(ll,18)(q21;q21) [4] 46,XY,t(ll;18)(q21;q21) [13]/46,XY [5] 46,XX,t(ll;18)(q21;q21) [27]/46,XX [12] 46,XX,t(TT,T8) (q21 ;q21) [22] 46,XY,t(ll;18)(q21;q21) [27]/47,XY,+3 [3] 46,XY,t(ll;18)(q21;q21) [7] 46,XX,t(ll;18)(q21;q21)[ll]/46,XX [9] genetic, histopathologic and clinical characteristics (Tables 3 and 4), suggesting that the t(ll;18)(q21;q21) may identify the location of an oncogene important in the pathogenesis of MALT lymphoma in humans.…”

Section: Discussionmentioning

confidence: 99%

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t(11;18)(q21;q21) is the most common translocation in MALT lymphomas

Auer¹,

Gascoyne²,

Conners³

et al. 1997

Annals of Oncology

237

147

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

t(11;18)(q21;q21) is the most common translocation in MALT lymphomas

Auer¹,

Gascoyne²,

Conners³

et al. 1997

Annals of Oncology

237

147

View full text Add to dashboard Cite

“…4 The pathogenesis of primary pulmonary lymphoma has not yet been clearly established, but an association with chromosome translocation t(11;12;18) (q13;q13;12) has been described. 5 The criteria for diagnosis of primary pulmonary lymphoma include the following : (i) the lung or bronchus, or both, are involved but without evidence of mediastinal or hilar lymphadenopathy on thoracic imaging; (ii) no previous diagnosis of extrathoracic lymphoma has been made; (iii) no concurrent diagnosis of lymphatic leukemia is present; and (iv) the disease is not present outside the thorax for a period of at least 3 months from the time of diagnosis. 6,7 These features are an extension of the Saltztein criteria for this disease.…”

Section: Discussionmentioning

confidence: 99%

A Pulmonary Lesion Which Is More Than Meets the Eye

Gunaratnam¹,

Murphy²,

Razak³

et al. 2004

Clinical Pulmonary Medicine

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A 69-year-old female smoker presented with dyspnea, anorexia, weight loss, and bone pain. Chest radiography showed a large pulmonary mass. Initial clinical investigations suggested probable metastatic bronchogenic carcinoma, but biopsy revealed that the lesion represented primary pulmonary lymphoma. The pathogenesis of primary pulmonary parenchymal lymphoma is discussed, and differential diagnosis of this entity is reviewed.A 69-year-old woman presented with a 3 month history of increasing dyspnea, anorexia, and weight loss of 4 kg. She also complained of lower back and right-sided chest wall pain at presentation. The past medical history was remarkable for chronic obstructive pulmonary disease and a 40 pack a year history of smoking.Mild bilateral wheezing was noted on physical examination, but evidence of digital clubbing, lymphadenopathy, or focal bone tenderness was not noted. Chest radiography showed a 4-ϫ-6-cm left lower lobe mass ( Fig. 1). Laboratory investigations were remarkable only for an elevated erythrocyte sedimentation rate of 39 mm/hour (normal Ͻ12 mm/ hour).Thoracic computed tomography (CT; Fig. 2) demonstrated emphysema and a left anterior-medial basal segment mass, but no evidence of lymphadenopathy or other pulmonary abnormalities was found. No adrenal lesions were noted. Radionuclide bone scanning showed focal tracer accumulation within the T9 thoracic vertebral body and within 2 right lower posterior ribs. Bronchogenic carcinoma, possibly metastatic, was the presumptive diagnosis.Flexible fiberoptic bronchoscopy was performed and showed an endobronchial lesion within the left anterior basal region. Endobronchial biopsies and bronchoalveolar washings were performed and sent for histopathological assessment.Histopathological assessment of the material obtained at bronchoscopy showed sheets of large, pleomorphic, malignant appearing lymphoid cells (Fig. 3). Epithelial markers CAM 5.2 and AE1/AE3 for carcinoma were negative. These findings were consistent with high grade, large B-cell lymphoma.CT scanning of the abdomen and the pelvis performed for staging revealed no significant abnormalities. Bone marrow aspirate and biopsy showed normal cellularity. Hematological investigations were normal. Dedicated radiographs of the right lower ribs and the thoracic spine showed that the areas of tracer accumulation on the bone scan represented degenerative changes. Based on CT findings, analysis of the histopathological specimens, and the bone marrow aspirate, a diagnosis of stage II E non-Hodgkin primary pulmonary lymphoma was made. The patient underwent standard CHOP regimen chemotherapy; cyclophosphamide 750 mg/m 2 IV on day 1, doxorubicin 50 mg/m 2 IV on day 1, vincristine 1.4 mg/m 2 IV capped at 2 mg on day 1, and prednisolone 100 mg PO qd on days 1 through 5. This regimen was repeated every 21 days for 4 cycles.

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Reinterpretation of G-banded complex karyotypes by fluorescence in situ hybridization with chromosome-specific DNA painting probes and alpha-satellite centromere-specific DNA probes in malignant hematological disorders

1997

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In this study, we have performed fluorescence in situ hybridization (FISH) with chromosome-specific DNA painting probes 1, 2, 3, 4, 6, 8, and 12 and centromere-specific DNA probes 7, 10, 12, 17, 18, and X after G-banding on the same metaphase spreads from four patients with malignant hematological disorders to more precisely interpret their complex karyotypes. The findings demonstrated that the application of combined G-banding and FISH can more accurately explain complex karyotypes of hematological malignancies. FISH can detect not only the origin of marker chromosomes, but also the complex rearrangements that cannot be identified by routine banding techniques. This approach is very important to complement the cytogenetic analysis of malignant disorders and to evaluate the role of chromosome change in the development, progression, and prognosis of tumors. Am. J. Hematol. 55:69-76, 1997.

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A unique chromosome translocation, t(11;12;18)(q13;q13;q12), in primary lung lymphoma

Cited by 17 publications

References 14 publications

t(11;18)(q21;q21) is the most common translocation in MALT lymphomas

t(11;18)(q21;q21) is the most common translocation in MALT lymphomas

A Pulmonary Lesion Which Is More Than Meets the Eye

Reinterpretation of G-banded complex karyotypes by fluorescence in situ hybridization with chromosome-specific DNA painting probes and alpha-satellite centromere-specific DNA probes in malignant hematological disorders

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