A unique case of human Zika virus infection in association with severe liver injury and coagulation disorders

Wu, Yongfeng; Cui, Xiaoyun; Wu, Na; Song, Rui; Yang, Wei; Zhang, Wei; Fan, Dongying; Chen, Zhihai; An, Jing

doi:10.1038/s41598-017-11568-4

Cited by 34 publications

(34 citation statements)

References 25 publications

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“…Furthermore, there was a case reported in 2017 that a patient with human Zika virus infection had markedly elevated LDH, which was associated with 70% mortality in further a Zika-infected animal study. They considered LDH as an indicator of multiorgan injury, not only affecting liver or cardiac function [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Lactate dehydrogenase, an independent risk factor of severe COVID-19 patients: a retrospective and observational study

Han

Zhang

et al. 2020

Aging

215

171

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Background: The World Health Organization has declared coronavirus disease 2019 (COVID-19) a public health emergency of global concern. Updated analysis of cases might help identify the risk factors of illness severity. Results: The median age was 63 years, and 44.9% were severe cases. Severe patients had higher APACHE II (8.5 vs. 4.0) and SOFA (2 vs. 1) scores on admission. Among all univariable parameters, lymphocytes, CRP, and LDH were significantly independent risk factors of COVID-19 severity. LDH was positively related both with APACHE II and SOFA scores, as well as P/F ratio and CT scores. LDH (AUC = 0.878) also had a maximum specificity (96.9%), with the cutoff value of 344.5. In addition, LDH was positively correlated with CRP, AST, BNP and cTnI, while negatively correlated with lymphocytes and its subsets. Conclusions: This study showed that LDH could be identified as a powerful predictive factor for early recognition of lung injury and severe COVID-19 cases. Methods: We extracted data regarding 107 patients with confirmed COVID-19 from Renmin Hospital of Wuhan University. The degree of severity of COVID-19 patients (severe vs. non-severe) was defined at the time of admission according to American Thoracic Society guidelines for community acquired pneumonia.

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Section: Discussionmentioning

confidence: 99%

Lactate dehydrogenase, an independent risk factor of severe COVID-19 patients: a retrospective and observational study

Han

Zhang

et al. 2020

Aging

215

171

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“…preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in further Zika infected animal study. They considered LDH as an indicator of multiorgan injury, not only affecting liver or cardiac function (15).…”

Section: Discussionmentioning

confidence: 99%

Lactate dehydrogenase, a Risk Factor of Severe COVID-19 Patients: A Retrospective and Observational Study

Han¹,

Zhang²,

Mu³

et al. 2020

Preprint

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BACKGROUNDThe World Health Organization (WHO) has recently declared coronavirus disease 2019 (COVID-19) a public health emergency of global concern. Updated analysis of cases might help identify the characteristic and risk factors of the illness severity. METHODSWe extracted data regarding 47 patients with confirmed COVID-19 from Renmin Hospital of Wuhan University between February 1 and February 18, 2020. The degree of severity of COVID-19 patients (severe vs. non-severe) was defined at the time of admission according to American Thoracic Society (ATS) guidelines for communityacquired pneumonia (CAP). RESULTSThe median age was 64.91 years, 26 cases (55.31%) were male of which, and 70.83% were severe cases. Severe patients had higher APACHE II (9.92 vs 4.74) and SOFA (3.0 vs 1.0) scores on admission, as well as the higher PSI (86.13 vs 61.39), Curb-65 (1.14 vs 0.48) and CT semiquantitative scores (5.0 vs 2.0) when compared with nonsevere patients. Among all univariable parameters, APACHE II, SOFA, lymphocytes, CRP, LDH, AST, cTnI, BNP, et al were significantly independent risk factors of COVID-19 severity. Among which, LDH was most positively related both with APACHE II (R = 0.682) and SOFA (R = 0.790) scores, as well as PSI (R = 0.465) andCT (R = 0.837) scores. To assess the diagnostic value of these selected parameters, LDH (0.9727) had maximum sensitivity (100.00%) and specificity (86.67%), with the cutoff value of 283. As a protective factor, lymphocyte counts less than 1.045 x 10 9 /L showed a good accuracy for identification of severe patients with AUC = 0.9845 (95%CI 0.959-1.01), the maximum specificity (91.30%) and sensitivity (95.24%). In addition, LDH was positively correlated with CRP, AST, BNP and cTnI, while negatively correlated with lymphocyte cells and its subsets, including CD3 + , CD4 + and CD8 + T cells (P < 0.01).

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“…Others have shown that serum ALT is elevated following ZIKV infection [ 63 , 64 , 66 , 71 ], in both rhesus and cynomolgus macaques as well as following DENV-2 infections in African green monkeys ( Chlorocebus aethiops ) [ 84 ]. Human disease does not necessarily present with elevated ALT levels but can in cases be associated with hepatic disease and coagulopathy [ 85 ].…”

Section: Discussionmentioning

confidence: 99%

ZIKV Demonstrates Minimal Pathologic Effects and Mosquito Infectivity in Viremic Cynomolgus Macaques

Azar

Rossi

Haller

et al. 2018

Viruses

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To evaluate the effects of ZIKV infection on non-human primates (NHPs), as well as to investigate whether these NHPs develop sufficient viremia to infect the major urban vector mosquito, Aedes aegypti, four cynomolgus macaques (Macaca fascicularis) were subcutaneously infected with 5.0 log10 focus-forming units (FFU) of DNA clone-derived ZIKV strain FSS13025 (Asian lineage, Cambodia, 2010). Following infection, the animals were sampled (blood, urine, tears, and saliva), underwent daily health monitoring, and were exposed to Ae. aegypti at specified time points. All four animals developed viremia, which peaked 3–4 days post-infection at a maximum value of 6.9 log10 genome copies/mL. No virus was detected in urine, tears, or saliva. Infection by ZIKV caused minimal overt disease: serum biochemistry and CBC values largely fell within the normal ranges, and cytokine elevations were minimal. Strikingly, the minimally colonized population of Ae. aegypti exposed to viremic animals demonstrated a maximum infection rate of 26% during peak viremia, with two of the four macaques failing to infect a single mosquito at any time point. These data indicate that cynomolgus macaques may be an effective model for ZIKV infection of humans and highlights the relative refractoriness of Ae. aegypti for ZIKV infection at the levels of viremia observed.

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A unique case of human Zika virus infection in association with severe liver injury and coagulation disorders

Cited by 34 publications

References 25 publications

Lactate dehydrogenase, an independent risk factor of severe COVID-19 patients: a retrospective and observational study

Lactate dehydrogenase, an independent risk factor of severe COVID-19 patients: a retrospective and observational study

Lactate dehydrogenase, a Risk Factor of Severe COVID-19 Patients: A Retrospective and Observational Study

ZIKV Demonstrates Minimal Pathologic Effects and Mosquito Infectivity in Viremic Cynomolgus Macaques

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