A Unique Case of Cerebral Spleen

Rickert, Christian H.; Maasjosthusmann, Ulrich; Probst‐Cousin, Stefan; August, Christian; Gullotta, F.

doi:10.1097/00000478-199807000-00011

Cited by 75 publications

(41 citation statements)

References 11 publications

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“…The cells can implant in any other location and take their blood supply from surrounding structures; splenosis has been reported as intrathoracic where there is a concomitant diaphragmatic injury or intrahepatic following an emergency splenectomy for trauma [4,5] . The pathogenesis is generally accepted to be mechanical implantation of cells, however there are case reports of intracranial splenic deposits from purported haematological spread [6] . Whilst it is assumed to be functional splenic tissue, splenosis usually does not have the histological appearance of normal spleen, nor does it form a hilum or a mature capsule.…”

Section: Discussionmentioning

confidence: 99%

Splenunculi mimicking metastases in a patient with locally advanced prostate cancer

Foreman¹,

Plagakis²

2016

WJCU

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Informed consent statement: The patient gave informed verbal consent for the use of his medical details in this publication.Conflict-of-interest statement: There were no conflicts of interest in this study. AbstractA 61-year-old man with locally advanced prostate cancer was found to have multiple solid intra-abdominal solid lesions during staging investigations. While some were in the pelvis, they were not located in the common landing sites for prostate cancer metastases, and his prostate specific antigen was not significantly elevated to suggest a high burden of metastatic disease. He reported a history of a blunt abdominal trauma due to a motor vehicle accident more than forty years ago which had been conservatively managed. His staging imaging revealed a lack of a discrete spleen in his left upper abdomen and this raised the suspicion that these solid lesions may represent ectopic splenic tissue. Imaging with nuclear medicine scintigraphy confirmed the lesions in his upper abdomen and pelvis to be splenunculi. He proceeded with a combination of androgen deprivation therapy and external beam radiotherapy for locally advanced, non-metastatic prostate cancer. Although it has been described in patients with low risk prostate cancer, this is the first case report of splenunculi mimicking metastases in a patient with locally advanced prostate cancer.

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Section: Discussionmentioning

confidence: 99%

Splenunculi mimicking metastases in a patient with locally advanced prostate cancer

Foreman¹,

Plagakis²

2016

WJCU

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“…It is supposed that the number of nodules of ectopic splenic tissue that develop in the peritoneal cavity correlates with the severity of splenic injury. Another mechanism of splenic tissue transplantation is splenic vein emboli or hematogenous spread of splenic pulp, which is suggested by cases of intrahepatic and intracranial splenosis (13,14). One theory suggests that splenic erythrocytic progenitor cells enter the liver via the portal vein, and then grow in response to tissue hypoxia (15).…”

Section: Discussionmentioning

confidence: 99%

Pelvic splenosis mimicking ovarian metastasis of breast carcinoma: a case report

Metindir¹,

Mersin²,

Bulut³

2011

J Turkish German Gynecol Assoc

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Splenosis is the heterotopic autotransplantation of splenic tissue that usually follows traumatic splenic rupture and splenectomy. Implanted splenic tissue may give rise to a mass or masses in the chest, abdomen, or pelvis which the clinician must distinguish from benign or malignant tumors. A 38-year-old multiparous woman presented for a routine gynecological examination during breast cancer treatment. She had undergone splenectomy following traumatic splenic rupture at the age of 13. Pelvic examination revealed a left adnexal mass. Transvaginal ultrasonography showed a 39x56x40 mm diameter hyperechoic, hypervascular solid tumor on the left ovary. Total abdominal hysterectomy and bilateral salpingo-oophorectomy was performed. The postoperative histological diagnosis was splenic tissue. Splenosis must be considered in the differential diagnosis of previosly splenectomized patients who present with unexplained masses.

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“…Another mechanism of splenic tissue transplantation is splenic vein emboli or hematogenous spread of splenic pulp, which is suggested by cases of intrahepatic and intracranial splenosis (5,(12)(13)(14). One theory suggests that splenic erythrocytic progenitor cells enter the liver via the portal vein, and then grow in response to tissue hypoxia (15).…”

Section: Discussionmentioning

confidence: 99%