A Unique Case of Bannwarth Syndrome in Early Disseminated Lyme Disease

Omotosho, Yetunde B; Sherchan, Robin; Ying, Grace W; Shayuk, Maryna

doi:10.7759/cureus.14680

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…En adultos, la neuroborreliosis se presenta con mayor frecuencia como síndrome de Bannwarth, que se caracteriza por dolor radicular (100%), trastornos del sueño (75,3%), cefalea (46,8%), fatiga (44,2%), malestar (39%), parestesias (32,5%), signos meníngeos (19,5%) y paresia (7,8%) 13 . Según Roaldsnes y cols., no muy frecuentemente, puede haber neuropatía periférica, deterioro cognitivo, ataxia cerebelosa, encefalitis y mielitis 14 .…”

Section: Discussionunclassified

Encefalitis aguda con síndrome cerebeloso secundario a neuroborreliosis

Aguilar-Andino,

Medina Santos,

Umaña

et al. 2023

Rev. chil. infectol.

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Sin financiamiento. Sin conflicto de interés.Recibido: 5 de septiembre de 2022 / Aceptado: 26 de junio de 2023 ResumenLa enfermedad de Lyme es la infección transmitida por garrapatas más común en Norteamérica y Europa. Sin embargo, en América Latina se han reportado pocos datos. Borrelia burgdorferi es capaz de invadir el sistema nervioso central causando la neuroborreliosis de Lyme. Se comunica el caso de una mujer joven con encefalitis y síndrome cerebeloso, una presentación poco frecuente, que se manifestó con cefalea, marcha atáxica, nistagmo y ptosis palpebral. Se realizó el diagnóstico con serología positiva por Western blot para Borrelia burgdorferi en suero. Recibió tratamiento con mejoría clínica. El diagnóstico de neuroborreliosis es difícil, ya que no existen hallazgos neurológicos o de imagen específicos. Se recomienda tener un mayor nivel de vigilancia epidemiológica en Latinoamérica, así como los antecedentes recreativos o viajes, que deben incluirse en la historia clínica para mejorar la aproximación diagnóstica.Palabras clave: enfermedad de Lyme; neuroborreliosis; enfermedad cerebelosa; infecciones del sistema nervioso central.

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Section: Discussionunclassified

Encefalitis aguda con síndrome cerebeloso secundario a neuroborreliosis

Aguilar-Andino,

Medina Santos,

Umaña

et al. 2023

Rev. chil. infectol.

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“…Borrelia burgdorferi sensu stricto (s.s.) is the major cause of LD in North America; however, its impact on European LD is under-appreciated [36,37]. The most frequent manifestation of B. burgdorferi s.s.-induced neuroborreliosis in the United States is lymphocytic meningitis, whereas European B. garinii-induced LNB, in the majority of cases, is diagnosed as Bannwarth syndrome, with the classic triad of meningitis, cranial neuritis, and painful radiculoneuritis [38], an uncommon manifestation of LNB in the USA [39]. Such differences in clinical manifestations of LNB might be based on different mechanisms of dissemination of the bacterial pathogen into the nervous system, different capabilities of individual species to cross the blood-brain barrier (BBB) by either transcellular or paracellular penetration [40], or hypervariable OspC genotypes [41].…”

Section: Introductionmentioning

confidence: 99%

Concurrent Infection of the Human Brain with Multiple Borrelia Species

Golovchenko,

Opelka,

Vancova

et al. 2023

IJMS

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Lyme disease (LD) spirochetes are well known to be able to disseminate into the tissues of infected hosts, including humans. The diverse strategies used by spirochetes to avoid the host immune system and persist in the host include active immune suppression, induction of immune tolerance, phase and antigenic variation, intracellular seclusion, changing of morphological and physiological state in varying environments, formation of biofilms and persistent forms, and, importantly, incursion into immune-privileged sites such as the brain. Invasion of immune-privileged sites allows the spirochetes to not only escape from the host immune system but can also reduce the efficacy of antibiotic therapy. Here we present a case of the detection of spirochetal DNA in multiple loci in a LD patient’s post-mortem brain. The presence of co-infection with Borrelia burgdorferi sensu stricto and Borrelia garinii in this LD patient’s brain was confirmed by PCR. Even though both spirochete species were simultaneously present in human brain tissue, the brain regions where the two species were detected were different and non-overlapping. The presence of atypical spirochete morphology was noted by immunohistochemistry of the brain samples. Atypical morphology was also found in the tissues of experimentally infected mice, which were used as a control.

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Urinary Tract Dysfunction in Other Rare Neurological Diseases

Sakakibara¹,

Liu²

2023

Handbook of Neurourology

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A Unique Case of Bannwarth Syndrome in Early Disseminated Lyme Disease

Cited by 4 publications

References 17 publications

Encefalitis aguda con síndrome cerebeloso secundario a neuroborreliosis

Encefalitis aguda con síndrome cerebeloso secundario a neuroborreliosis

Concurrent Infection of the Human Brain with Multiple Borrelia Species

Urinary Tract Dysfunction in Other Rare Neurological Diseases

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