A Unique Case of Alpha-Fetoprotein-Negative Hepatoid Adenocarcinoma of the Stomach With Associated Signet Ring Cell Histological Features and Linitis Plastica

Abstract

Wichelmann et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Alpha-Fetoprotein (AFP)-Negative Hepatoid Adenocarcinoma of the Stomach and its Associated Uncommon Features With a Review

“…We reviewed the clinicopathological features of AFP-negative hepatoid adenocarcinoma and is depicted in Table 1. 3,[8][9][10] Histomorphologically, the present tumor showed solid, cords, trabecular, and pseudoglandular patterns of tumor cells. Individual tumor cells are large polygonal cells with abundant eosinophilic granular cytoplasm containing glycogen (PAS positive); some of which contain hyaline globules, centrally placed round to oval nucleus that resembles a welldifferentiated hepatocellular carcinoma (HCC).…”

“…Only less than 20 cases of AFP-negative hepatoid adenocarcinoma have been reported in the literature. 3,8–10 We report an additional case of AFP-negative hepatoid adenocarcinoma and discuss the uncommon histologic features present in our case that are not reported to date and its literature review.…”

“…Some of the AFP-negative hepatoid adenocarcinoma tumors showed tubular patterns and one case associated showed signet ring cell carcinoma. 10 On IHC, AFP was negative. AFP is produced during fetal life by the liver, and yolk sac, and the serum level will come to normal after birth.…”

“…We reviewed the clinicopathological features of AFP-negative hepatoid adenocarcinoma and is depicted in Table 1. 3,8–10…”

“…Some of the AFP-negative hepatoid adenocarcinoma tumors showed tubular patterns and one case associated showed signet ring cell carcinoma. 10…”