2021
DOI: 10.1016/j.coi.2020.08.002
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A unifying hypothesis on the central role of reactive oxygen species in bacterial pathogenesis and host defense in C. elegans

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Cited by 17 publications
(9 citation statements)
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“…Excessive levels of ROS can cause oxidative stress and cellular damage in organisms . Compound A7 at 2, 5, and 10 mg/L caused a significant increase in the ROS levels in B.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Excessive levels of ROS can cause oxidative stress and cellular damage in organisms . Compound A7 at 2, 5, and 10 mg/L caused a significant increase in the ROS levels in B.…”
Section: Resultsmentioning
confidence: 99%
“…28 oxidative stress and cellular damage in organisms. 41 Compound A7 at 2, 5, and 10 mg/L caused a significant increase in the ROS levels in B. xylophilus (Figure 5A,B). As the concentration of compound A7 gradually increased, the level of ROS in the nematodes also increased.…”
Section: ■ Materials and Methodsmentioning
confidence: 97%
“…ROS, which include hydroxyl radicals, superoxide anions, and hydrogen peroxide, are generated from oxygen reduction. While excessive ROS can be toxic to cells ( 74 77 ), they also serve a protective function by killing invading bacteria and fungi ( 72 , 78 ), suggesting dual roles in innate immunity. Recent studies demonstrated that ROS also affect pathogen avoidance ( Figure 1 ).…”
Section: Signalling Crosstalk Between Pathogen Avoidance and Innate I...mentioning
confidence: 99%
“…All organisms have developed mechanisms to cope with stress, and failure to maintain appropriate levels of ROS usually causes oxidative stress and cellular damage. 46,74,75 According to a recent publication, C. elegans' growth, locomotion behavior, feeding, lifespan, and reproduction can be harmed by sublethal exposure to flu, which also induces oxidative stress, as indicated by an increase in ROS production. 30 To explore the mechanism of SPc-based bioactivity enhancement, oxidative stress was also investigated by measuring ROS production.…”
Section: Amplified Adverse Impacts Of Flu Nanoagents On Oxidative Str...mentioning
confidence: 99%