Fractional calculus provides a rigorous mathematical framework to describe anomalous stochastic processes by generalizing the notion of classical differential equations to their fractional-order counterparts. By introducing the fractional orders as uncertain variables, we develop an operator-based uncertainty quantification framework in the context of stochastic fractional partial differential equations (SFPDEs), subject to additive random noise. We characterize different sources of uncertainty and then, propagate their associated randomness to the system response by employing a probabilistic collocation method (PCM). We develop a fast, stable, and convergent Petrov-Galerkin spectral method in the physical domain in order to formulate the forward solver in simulating each realization of random variables in the sampling procedure.Key words. Stochastic fractional PDEs, forward uncertainty quantification, Monte Carlo simulation, probabilistic collocation method, Smolyak sparse grid, Petrov-Galerkin spectral method.1. Introduction. Fractional models construct a tractable mathematical framework to describe and predict the behavior of multi-scales multi-physics complex phenomena. Particularly, fractional differential equations, as a well-structured generalization of their integer order counterparts, provide a rigorous mathematical tool to develop models, describing anomalous behavior in complex physical systems [79,25,27,17,24,45,46,8,43], where the anomalies manifest in heavy tailed distribution of corresponding underlying stochastic processes, moreover, exhibiting sharp peaks, intermittency, and asymmetry in the underlying distributions. Significant approximations as inherent part of assumptions upon which the model is built, lack of information about true values of parameters (incomplete data), and random nature of quantities being modeled pervade uncertainty in the corresponding mathematical formulations [16,55]. In this work, we develop an uncertainty quantification (UQ) framework in the context of stochastic fractional partial differential equations (SFPDEs), in which we characterize different sources of uncertainties and further propagate the associated randomness to the system response quantity of interest (QoI).Types and Sources of Uncertainty. The model uncertainties are in general being classified as aleatory, epistemic, and mixed, according to their fundamental essence. They can also be broadly characterized as occurring in model inputs, numerical approximations, and model form. Model inputs encompass all model parameters coming from geometry, constitutive laws, and fields equation, while also pertaining surrounding interactions, such as boundary conditions and random forcing sources (noise). Numerical approximations, which are an essence of differential equations since they generally do not lend themselves to analytical solutions, introduce uncertainty by imposing different sources of discretization error, iterative convergence error, and round off error. The fractional derivatives introduce derivative ord...