A Unified Nomenclature for Yeast Autophagy-Related Genes

Klionsky, Daniel J.; Cregg, James M.; Dunn, William A.; Emr, Scott D.; Sakai, Yasuyoshi; Sandoval, Ignacio V.; Sibirny, Andriy А.; Subramani, Suresh; Thumm, Michael; Veenhuis, Marten; Ohsumi, Yoshinori

doi:10.1016/s1534-5807(03)00296-x

Cited by 1,129 publications

(829 citation statements)

References 90 publications

Supporting

Mentioning

806

Contrasting

Unclassified

Order By: Relevance

“…Yeast genetic studies have identified more than 20 genes (ATG genes) required for autophagy, most of which function in autophagosome formation. 3,4 With these remarkable findings, studies of autophagy have been rapidly progressed for the past decade. In particular, biological significance of autophagy is now being revealed in various organisms.…”

Section: Introductionmentioning

confidence: 99%

The pleiotropic role of autophagy: from protein metabolism to bactericide

2005

View full text Add to dashboard Cite

Autophagy is in principle a nonselective, bulk degradation system within cells, with a contribution to intracellular protein degradation estimated to be as large as that of the ubiquitin--proteasome system. The primary roles of autophagy are baseline turnover of intracellular proteins and organelles, production of amino acids in nutrient emergency, and regression of retired tissues. These functions guarantee rejuvenation and adaptation to adverse conditions, and even underlie dynamic processes such as development/metamorphosis. In addition, several other roles for autophagy have recently been discovered, such as presentation of endogenous antigens and degradation of invasive bacteria. This review will discuss the biological significance of autophagy from yeast to higher eukaryotes.

show abstract

Section: Introductionmentioning

confidence: 99%

The pleiotropic role of autophagy: from protein metabolism to bactericide

2005

View full text Add to dashboard Cite

show abstract

“…[14][15][16][17] ATG16L1 encodes a protein that interacts with the Atg12p-Atg5p conjugate during formation of the preautophagosomal structure, which is essential for autophagy. [18][19][20] Association of CD with the ATG16L1 T300A (rs2241880) polymorphism was reported simultaneously by different GWASs. [14][15][16] A large number of subsequent association studies have replicated the strong association of this gene with CD.…”

Section: Introductionmentioning

confidence: 99%

Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: a meta-analysis approach

et al. 2009

View full text Add to dashboard Cite

The aim of this study was to determine the role of the ATG16L1 (rs2241880) and IRGM (rs13361189 and rs4958847) genes polymorphism in Crohn's disease (CD) and ulcerative colitis (UC). Our study included 557 CD and 425 UC patients and 672 ethnically matched Spanish controls and a meta-analysis with the data published to date. The polymorphisms were genotyped using predesigned TaqMan single nucleotide polymorphism genotyping assays. There was a statistically significant difference in the distribution of the ATG16L1 rs2241880 G allele between CD patients and controls in the Spanish population: P ¼ 6.5 Â 10 À9 , odds ratio (OR) ¼ 1.62. Although no differences were observed between UC patients and controls in the Spanish cohort, a meta-analysis demonstrated that the ATG16L1 G allele increase significantly risk for UC (P ¼ 0.0003, pooled OR ¼ 1.08). In addition, our meta-analysis data showed that IRGM rs13361189 and rs4958847 polymorphisms were associated with CD (rs13361189 C allele P ¼ 1.07 Â 10 À19 , pooled OR ¼ 1.34; rs4958847 A allele P ¼ 2.78 Â 10 À17 , pooled OR ¼ 1.31) and UC (rs13361189 P ¼ 0.0069, pooled OR ¼ 1.16; rs4958847 P ¼ 0.014, pooled OR ¼ 1.13). In conclusion, our results confirm the ATG16L1 rs2241880 and IRGM rs13361189 and rs4958847 polymorphisms as important markers for CD susceptibility and indicate that these variants are also associated with UC.

show abstract

“…Some similar, but not identical, mammalian counterparts of the yeast autophagic machinery have been identified, and a unified nomenclature was recently adopted. 5 Macroautophagy consists of a random sequestration of cytosolic portions in double-membrane-bound vesicles called autophagosomes. 1 Vesicular factors mediate the fusion of the outer membrane of autophagosomes with autolysosomes in mammals or with vacuoles in yeast.…”

Section: Introductionmentioning

confidence: 99%

Impairing the bioenergetic status and the biogenesis of mitochondria triggers mitophagy in yeast

et al. 2005

View full text Add to dashboard Cite

Autophagy, a highly regulated programme found in almost all eukaryotes, is mainly viewed as a catabolic process that degrades nonessential cellular components into molecular building blocks, subsequently available for biosynthesis at a lesser expense than de novo synthesis. Autophagy is largely known to be regulated by nutritional conditions. Here we show that, in yeast cells grown under nonstarving conditions, autophagy can be induced by mitochondrial dysfunction. Electron micrographs and biochemical studies show that an autophagic activity can result from impairing the mitochondrial electrochemical transmembrane potential. Furthermore, mitochondrial damage-induced autophagy results in the preferential degradation of impaired mitochondria (mitophagy), before leading to cell death. Mitophagy appears to rely on classical macroautophagy machinery while being independent of cellular ATP collapse. These results suggest that in this case, autophagy can be envisioned either as a process of mitochondrial quality control, or as an ultimate cellular response triggered when cells are overwhelmed with damaged mitochondria.

show abstract

A Unified Nomenclature for Yeast Autophagy-Related Genes

Abstract: Developmental Cell 5 (2003) 539-545. doi:10.1016/S1534-5807(03)00296-XReceived by publisher: 0000-01-01Harvest Date: 2016-01-04 12:23:40DOI: 10.1016/S1534-5807(03)00296-XPage Range: 539-54

Cited by 1,129 publications

References 90 publications

The pleiotropic role of autophagy: from protein metabolism to bactericide

The pleiotropic role of autophagy: from protein metabolism to bactericide

Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: a meta-analysis approach

Impairing the bioenergetic status and the biogenesis of mitochondria triggers mitophagy in yeast

Contact Info

Product

Resources

About