A unidirectional porous beta-tricalcium phosphate promotes angiogenesis in a vascularized pedicle rat model

Murayama, Akira; Ajiki, Takashi; Hayashi, Yukinori; Takeshita, Katsushi

doi:10.1016/j.jos.2019.07.015

Cited by 10 publications

(9 citation statements)

References 29 publications

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“…Makihara et al 6 demonstrated that this characteristic of UDPTCP allowed the rapid penetration of the tissue into the material when implanted in the tibia of rabbits. Similarly, using a rat model, Murayama et al 15 reported a faster infiltration of the bone into UDPTCP than into other types of β-TCP, resulting in a more rapid formation of capillaries throughout the UDPTCP. To the best of our knowledge, this was the first study that evaluated β-TCP remodeling in different structures and compared the CT attenuation values in humans.…”

Section: Discussionmentioning

confidence: 89%

A radiological study of bone remodeling with two different types of porous β-tricalcium phosphate in humans

Kikuchi

Yoshioka

Arai

et al. 2020

Sci Rep

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In this study we compared the bone remodeling of unidirectional (UDPTCP) and spherical porous β-tricalcium phosphate (SPTCP) radiologically in humans. We performed a retrospective analysis of the data of 14 patients (sex, nine men and five women; age, 37–70 years) who underwent medial opening-wedge high tibial osteotomy (MOWHTO) and were followed up for 12 months after surgery. Two wedge-shaped β-TCPs (one UDPTCP and one SPTCP) were cut and placed parallel to each other in the gap. In Group A (eight knees), UDPTCP was implanted anteriorly and SPTCP posteriorly, while in Group B (six knees), SPTCP was implanted anteriorly and UDPTCP posteriorly. Computed tomography (CT) was performed at 1 week, 6 months, and 12 months after surgery, with the CT attenuation values calculated for UDPTCP and SPTCP. In Groups A and B, the CT attenuation values for UDPTCP were significantly lower at 6 and 12 months after surgery compared to those at 1 week (P < 0.05); nevertheless, no statistical difference in the comparison with SPTCP was observed. After a short-term follow-up of 12 months following MOWHTO, UDPTCP provided earlier bone remodeling than SPTCP. This outcome was achieved regardless of the position, anterior or posterior, in the MOWHTO gap.

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Section: Discussionmentioning

confidence: 89%

A radiological study of bone remodeling with two different types of porous β-tricalcium phosphate in humans

Kikuchi

Yoshioka

Arai

et al. 2020

Sci Rep

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“…In fact, unidirectional porous β-TCP, Affinos ® promotes angiogenesis than β-TCP with a spherical interconnected porous structure [ 12 ] and absorption and replacement by the patient’s own bone occurred earlier in Affinos ® than in β-TCP with a spherical interconnected porous structure [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…It was determined that it is desirable to mix 50% or more of the autogenous bone when using Affinos ® for grafting near or outside the bone [ 11 ]. In a study from a different facility, it was reported that Affinos ® promotes angiogenesis than β-TCP bone with a spherical interconnected porous structure in a vascularized pedicle rat model [ 12 ].…”

Section: Animal Experiments During the Development Of Affinos ® Unidirectional Porous β-Tcpmentioning

confidence: 99%

Unidirectional porous beta-tricalcium phosphate and hydroxyapatite artificial bone: a review of experimental evaluations and clinical applications

et al. 2021

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In Japan, where allograft bone transplantation is not widespread, prospects for artificial bones are very high. Therefore, artificial bones with various compositions, porous structures, and porosities have been developed and employed for clinical use. Both Affinos® and Regenos® (made of beta-tricalcium phosphate and hydroxyapatite, respectively) are artificial bones with a unique unidirectional porous structure, in which pores with a diameter suitable for tissue penetration (25–300 μm) are aligned in one direction. The unidirectional porous structure allows rapid penetration of blood deep into the materials by a capillary effect. In animal experiments, Affinos® showed well-balanced resorption and was replaced with the host’s own bone from an early stage after implantation and new bone formation and remodeling were observed in the cortical bone and medullary cavity. When implanted for clinical situation, resorption from an early stage and good replacement with the patient’s own bone were also observed. Regenos® has an internal osteon-like material and a vascular-like structure that is maintained within the pores even after long-term implantation, as noted in an animal experiment. When implanted for clinical situation, good osteoconductivity was observed from an early stage of implantation. In addition, the material was observed to be slowly absorbed over time in some cases. We have discussed the beneficial effects of combining teriparatide and platelet-rich plasma impregnation and the potential prospects of these artificial bones.

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“…The use of porous scaffolds and their comparison was done by the group of Murayama. They compared different types of porosity in β-tricalcium phosphate scaffolds (β-TCP), in rats and showed that the pore structures were filled with capillaries after three weeks [36]. The same kind of scaffolds was also used by Gu and colleagues.…”

Section: Angiogenesis In Bone Transplantsmentioning

confidence: 99%

Polysaccharide-Based Systems for Targeted Stem Cell Differentiation and Bone Regeneration

et al. 2019

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Bone tissue engineering is an ever-changing, rapidly evolving, and highly interdisciplinary field of study, where scientists try to mimic natural bone structure as closely as possible in order to facilitate bone healing. New insights from cell biology, specifically from mesenchymal stem cell differentiation and signaling, lead to new approaches in bone regeneration. Novel scaffold and drug release materials based on polysaccharides gain increasing attention due to their wide availability and good biocompatibility to be used as hydrogels and/or hybrid components for drug release and tissue engineering. This article reviews the current state of the art, recent developments, and future perspectives in polysaccharide-based systems used for bone regeneration.

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A unidirectional porous beta-tricalcium phosphate promotes angiogenesis in a vascularized pedicle rat model

Cited by 10 publications

References 29 publications

A radiological study of bone remodeling with two different types of porous β-tricalcium phosphate in humans

A radiological study of bone remodeling with two different types of porous β-tricalcium phosphate in humans

Unidirectional porous beta-tricalcium phosphate and hydroxyapatite artificial bone: a review of experimental evaluations and clinical applications

Polysaccharide-Based Systems for Targeted Stem Cell Differentiation and Bone Regeneration

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