A Tyrosine Phosphatase is Associated with the Somatostatin Receptor

Delesque, Nathalie; Buscail, Louis; Estève, Jean-Pierre; Rauly, Isabelle; Zeggari, M.; Saint-Laurent, Nathalie; Bell, Graeme I.; Vaysse, Nicole; Susini, Christiane

doi:10.1002/9780470514733.ch12

Cited by 7 publications

(3 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Gq, G14, A c c e p t e d M a n u s c r i p t 4 G16). Depending on the cell type, the various sst subtypes have been shown to couple to a diversity of transduction systems (Patel, 1999;Delesque et al, 1995;Ferjoux et al, 2003;Lopez et al, 1996;ten Bokum et al, 2000;Weckbecker et al, 2003). Cortistatin has been shown to diminish cAMP levels through activation of each individual sst subtype (Fukusumi et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

The role of cortistatin in the human immune system

Hagen

Dalm

Staal

et al. 2008

Molecular and Cellular Endocrinology

View full text Add to dashboard Cite

Please cite this article as: van Hagen, P.M., Dalm, V.A., Staal, F., Hofland, L.J., The Role of Cortistatin in the Human Immune System, Molecular and Cellular Endocrinology (2007Endocrinology ( ), doi:10.1016Endocrinology ( /j.mce.2008 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractCortistatin (CST) is a recently described neuropeptide that shares high homology with somatostatin (somatotropin release-inhibiting factor, SRIF) and binds with high affinity to all somatostatin receptor (sst) subtypes. CST is currently known to have a widespread distribution in many human organs including the immune system. The activities specific to CST may be partially attributable to its binding to the growth hormone secretagogue (GHS) receptor (GHS-R) and the orphan Gprotein-coupled receptor MrgX2. Human immune cells produce CST, whereas macrophage lineage and activated endothelium express sst 2 , and human lymphocytes express sst 3 . The human thymus expresses sst 1,2,3 , MrgX2 and almost all immune cells express GHS-R. Moreover, at this very moment promising research with CST in experimental animal models is being performed. On the basis of these promising results, studies aiming to further evaluate the possibilities of CST as a therapeutic agent in human immune mediated inflammatory diseases are warranted.

show abstract

Section: Introductionmentioning

confidence: 99%

The role of cortistatin in the human immune system

Hagen

Dalm

Staal

et al. 2008

Molecular and Cellular Endocrinology

View full text Add to dashboard Cite

show abstract

“…The mechanism of the antiproliferative effect is uncertain, but inhibition of various hormone-releasing factors (including epidermal growth factor, transforming growth factor-b, growth hormone, and insulin-like growth factor-1), modulation of immune activity, and inhibition of angiogenesis have all been postulated. [25][26][27][28][29][30][31] At least 5 structurally related membrane SST receptors (SST1-SST5) have been identified. 32 The most common SST receptor expressed in human tumors is the SST2 subtype.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Tolerability of long-acting Octreotide in the Treatment of Thymic Tumors

Longo¹,

Filippis²,

Zivi³

et al. 2012

American Journal of Clinical Oncology

View full text Add to dashboard Cite

show abstract

“…Ζ ζςιαημζηαηίκδ αζηεί ηζξ θοζζμθμβζηέξ ηδξ δνάζεζξ ιέζς ιειανακζηχκ οπμδμπέςκ ορδθήξ ζοββέκεζαξ (Schonbrunn and Tashjian, 1978) μζ μπμίμζ ζογεφβκοκηαζ ιε Gπνςηεΐκεξ (Reisine and Bell, 1995b) ηαζ ζοκδέμκηαζ ιε πμθθαπθά εηηεθεζηζηά ζοζηήιαηα, υπςξ αοηά ηδξ αδεκοθζηήξ ηοηθάζδξ, δζαφθςκ ζυκηςκ ηαζ θςζθαηαζχκ ηδξ ηονμζίκδξ (Bruns et al, 1995, Delesque et al, 1995, Kleuss, 1995 (Reubi, 1984).…”

Section: γεμικάunclassified

Μελέτη Του Ρόλου Της Σωματοστατίνης Στο Μελάγχρουν Επιθήλιο Του Αμφιβληστροειδούς

Παπαδάκη¹

View full text Add to dashboard Cite

Μελζτθ τθσ παραγωγισ μεταβολιτϊν του μονοξειδίου του αηϊτου από τα κφτταρα D407 . 4.11 Μελζτθ τθσ επίδραςθσ τθσ ςωματοςτατίνθσ και των εκλεκτικϊν αναλόγων τθσ ςτον ρυκμό πολλαπλαςιαςμοφ των κυττάρων D407 με τθν τεχνικι μεταβολιςμοφ του ΜΣΣ .

show abstract

A Tyrosine Phosphatase is Associated with the Somatostatin Receptor

Cited by 7 publications

References 32 publications

The role of cortistatin in the human immune system

The role of cortistatin in the human immune system

Efficacy and Tolerability of long-acting Octreotide in the Treatment of Thymic Tumors

Μελέτη Του Ρόλου Της Σωματοστατίνης Στο Μελάγχρουν Επιθήλιο Του Αμφιβληστροειδούς

Contact Info

Product

Resources

About