A type of esophageal stent coating composed of one 5-fluorouracil-containing EVA layer and one drug-free protective layer: In vitro release, permeation and mechanical properties

Guo, Qinghai; Guo, Shouwu; Wang, Zhongmin

doi:10.1016/j.jconrel.2006.12.030

Cited by 57 publications

(48 citation statements)

References 23 publications

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“…Bronchotracheal stent coatings need to have proper flexibility to resist the rigors of compression and elongation required for deployment of the stent and subsequent peristaltic movements in situ (Guo et al, 2007). The tensible testing gives an indication of the strength and elasticity of the coating.…”

Section: Mechanical Properties Of the Pu Constructsmentioning

confidence: 99%

Gefitinib/gefitinib microspheres loaded polyurethane constructs as drug-eluting stent coating

Chen

Clauser

Thiebes

et al. 2017

European Journal of Pharmaceutical Sciences

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One of the complications of bronchotracheal cancer is obstruction of the upper airways. Local tumor resection in combination with an airway stent can suppress intraluminal tumor (re)growth. We have investigated a novel drug-eluting stent coating for local release of the anticancer drug gefitinib. A polyurethane (PU) sandwich construct was prepared by a spray coating method in which gefitinib was embedded between a PU support layer of 200 μm and a PU top layer of 50-200 μm. Gefitinib was either embedded in the construct as small crystals or as gefitinib-loaded poly(lactic-co-glycolic acid) (PLGA) microspheres (MSP). The drug was incorporated in the PU constructs with high recovery (83-93%), and the spray coating procedure did not affect the morphologies of the embedded microspheres as demonstrated by scanning electron microscopy (SEM), confocal laser scanning microscopy and fluorescence microscopy analysis. PU constructs loaded with gefitinib crystals released the drug for 7-21 days and showed diffusion based release kinetics. Importantly, directional release of the drug towards the top layer, which is supposed to face the tumor mass, was controlled by the thicknesses of the PU top layer. PU constructs loaded with gefitinib microspheres released the drug in a sustained manner for N 6 months indicating that drug release from the microspheres became the rate limiting step. In conclusion, the sandwich structure of drug-loaded PLGA microspheres in PU coating is a promising coating for airway stents that release anticancer drugs locally for a prolonged time.

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Section: Mechanical Properties Of the Pu Constructsmentioning

confidence: 99%

Gefitinib/gefitinib microspheres loaded polyurethane constructs as drug-eluting stent coating

Chen

Clauser

Thiebes

et al. 2017

European Journal of Pharmaceutical Sciences

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“…Effort has been directed toward suppressing the expansion of hyperplasia by covering the stent with polymeric film or membrane. The stent covering material should have a proper mechanical properties such as elasticity to accommodate the expansion required for the stent placed in a tortuous part of the vessel or tract, and toughness that could resist the rigors of compression to make the profile of the stent as small as possible so that it could be loaded into a delivery catheter with smallest diameter [46]. Minimal profile of the stent and delivery catheter is preferred so that they can be delivered through an endoscope as shown in Figure 3.…”

Section: Non-vascular Stentsmentioning

confidence: 99%

Local Delivery of Antiproliferative Agents via Stents

Kwon

Park

2014

Polymers

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Abstract:A stent is a medical device for serving as an internal scaffold to maintain or increase the lumen of a body conduit. Stent placement has become a primary treatment option in coronary artery disease for more than the last two decades. The stenting is also currently used for relieving the symptoms of narrowed lumen of nonvascular organs, such as esophagus, trachea and bronchi, small and large intestines, biliary, and urinary tract. Local delivery of active pharmaceutical agents via the stents can not only enhance healing of certain diseases, but it can also help decrease the potential risk of the stenting procedure to the surrounding tissue. In this review, we focus on reviewing a variety of drug-impregnated stents and local drug delivery systems using the stents.

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“…The drug-loaded stents and control stents were prepared in our lab as follows: the drug-loaded layer was prepared by fully blending 5-FU particles and melted EVA in various ratios and then compressing the blends into films with a heat source. 25 In brief, 50 g EVA was added into the chamber of HAAKE Rheocord System (Rheocord 90, HAAKE Mess-Technic GmbH, Karlsruhe, Germany) and heated until it was completely melted. Afterward, the micronized 5-FU was added slowly into the melted EVA at the weight ratios of 20/80, 40/60, and 60/40 (5-FU/EVA), and then blended at 958C for 2 h by stirring at 37 rpm.…”

Section: Fabrication Of Drug-loaded Stentsmentioning

confidence: 99%

“…In our previous study, 25,26 we developed a type of esophageal stent coating, which consists of one 5-FUcontaining ethylene-vinyl acetate (EVA) layer and one drug-free EVA protective layer. In the present study, we fabricate and evaluate in vivo a drug-loaded stent which is a combination of a self-expandable commercial nitinol stent and the above coating.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Evaluation of 5-Fluorouracil-Containing Self-Expandable Nitinol Stent in Rabbits: Efficiency in Long-Term Local Drug Delivery

Guo

Wang

Zhang

et al. 2010

Journal of Pharmaceutical Sciences

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A type of esophageal stent coating composed of one 5-fluorouracil-containing EVA layer and one drug-free protective layer: In vitro release, permeation and mechanical properties

Cited by 57 publications

References 23 publications

Gefitinib/gefitinib microspheres loaded polyurethane constructs as drug-eluting stent coating

Gefitinib/gefitinib microspheres loaded polyurethane constructs as drug-eluting stent coating

Local Delivery of Antiproliferative Agents via Stents

In Vivo Evaluation of 5-Fluorouracil-Containing Self-Expandable Nitinol Stent in Rabbits: Efficiency in Long-Term Local Drug Delivery

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