A two-step mechanism for the regulation of tryptophan pyrrolase

Julian, Jose; Chytil, Frank

doi:10.1016/0006-291x(69)90467-7

Cited by 14 publications

(3 citation statements)

References 7 publications

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“…GCs reach the nuclei of many cell types by forming a complex after binding to a specific cytoplasmic receptor protein ( Figure 1 ). There, they induce the synthesis of tyrosine-aminotransferase and tryptophan pyrrolase, 11 which exerts a number of tissue-specific and systemic effects as follows: reduction of chemotaxis, a pivotal process in inflammatory reactions and neutrophil activity, 12 reduction of vessel wall permeability, leading to less edema formation, exudation and migration of inflammatory cells, 10 reduction of antigen phagocytosis, 10 increase in hepatic gluconeogenesis, 10 downregulation of peripheral protein metabolism but enhanced hepatic protein synthesis, 10 alanine release from the musculature (increased plasma levels); this gluconeogenesis substrate surplus induces pancreatic glucagon secretion (from A cells) and subsequent hyperglucagonemia, 10 and fatty acid mobilization from subcutaneous storage (mainly in the extremities) and blockage of lipogenesis at these sites. In contrast, lipogenesis is increased in abdominal fat tissue.…”

Section: Immunosuppressive Drug Classesmentioning

confidence: 99%

Immunosuppression for in vivo research: state-of-the-art protocols and experimental approaches

et al. 2016

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Almost every experimental treatment strategy using non-autologous cell, tissue or organ transplantation is tested in small and large animal models before clinical translation. Because these strategies require immunosuppression in most cases, immunosuppressive protocols are a key element in transplantation experiments. However, standard immunosuppressive protocols are often applied without detailed knowledge regarding their efficacy within the particular experimental setting and in the chosen model species. Optimization of such protocols is pertinent to the translation of experimental results to human patients and thus warrants further investigation. This review summarizes current knowledge regarding immunosuppressive drug classes as well as their dosages and application regimens with consideration of species-specific drug metabolization and side effects. It also summarizes contemporary knowledge of novel immunomodulatory strategies, such as the use of mesenchymal stem cells or antibodies. Thus, this review is intended to serve as a state-of-the-art compendium for researchers to refine applied experimental immunosuppression and immunomodulation strategies to enhance the predictive value of preclinical transplantation studies.

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Section: Immunosuppressive Drug Classesmentioning

confidence: 99%

Immunosuppression for in vivo research: state-of-the-art protocols and experimental approaches

et al. 2016

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“…Pituitary-adrenal activation,[19] or exogenous hydrocortisone administration,[20] have been demonstrated to increase the synthesis of tryptophan pyrrolase. This may lead to increased degradation of tryptophan, and in turn, reduction in 5-HT levels, which may lead to depression.…”

Section: Discussionmentioning

confidence: 99%

“…[21] It is also demonstrated that the rise of tryptophan pyrrolase activity, mediated by hydrocortisone, was prevented by the concurrent administration of the xanthine oxidase inhibitor, allopurinol. [20]…”

Section: Discussionmentioning

confidence: 99%

Evaluation of effect of allopurinol and febuxostat in behavioral model of depression in mice

2013

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Objective:To evaluate the effects of allopurinol and febuxostat on depression using Forced Swim Test (FST) in mice.Materials and Methods:Allopurinol (39 mg/kg p. o) and febuxostat (15.6 mg/kg p. o) were administered once daily for 21 successive days to Swiss Albino mice. On the 21st day, the effect of the drug on locomotion was tested using photo-actometer followed by the recording of immobility period in the FST and the results were compared with the standard drug fluoxetine (10 mg/kg p. o).Results:Allopurinol and febuxostat expressed significant antidepressant like effect as indicated by reduction in the immobility period of mice in the FST as compared to control group. The effects of allopurinol and febuxostat were found to be comparable to that of fluoxetine.Conclusion:The results of the present study indicate that allopurinol and febuxostat possess significant antidepressant like activity.

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Glucocorticoid Therapy

Kannan

1988

The Adrenal Gland

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A two-step mechanism for the regulation of tryptophan pyrrolase

Cited by 14 publications

References 7 publications

Immunosuppression for in vivo research: state-of-the-art protocols and experimental approaches

Immunosuppression for in vivo research: state-of-the-art protocols and experimental approaches

Evaluation of effect of allopurinol and febuxostat in behavioral model of depression in mice

Glucocorticoid Therapy

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