A Two-Stage Matched Case–Control Study on Multiple Hypertensive Candidate Genes in Han Chinese

Kuo, Tai Yue; Kang, Mei Jyh; Chen, Jaw Wen; Ho, Hung Yun; Ting, Chih Tai; Lin, Tsung-Hsien; Sheu, Sheng Hsiung; Tsai, Wei Chuan; Chen, Jyh Hong; Leu, Hsin Bang; Yin, Wei Hsian; Chiu, Tai‐Yuan; Chen, Chin Iuan; Lin, Shing Jong; Pan, Wen Harn

doi:10.1038/ajh.2012.44

Cited by 5 publications

(4 citation statements)

References 38 publications

(20 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, gene-gene interactions should be taken into consideration. Until now, >500 candidate genes for hypertension have been suggested from a variety of genetic studies, and this number continues to increase [1], but not all of these genes were associated with an increased risk of stroke. Distribution of the C825T genotypes varies greatly in different ethnicities and the frequency of the T allele is highest in Africans, lowest in Caucasians, and intermediate in Asians.…”

Section: Discussionmentioning

confidence: 99%

“…Hypertension is a major risk factor of stroke, cardiovascular disease, and end-stage renal disease and affects about 1 billion adults worldwide, including 3.8 million in Taiwan and 160 million in China [1]. Stroke is a primary contributor to long-term adult disability and the third most common cause of death in developed countries [2], [3].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The C825T Polymorphism of the G-Protein β3 Subunit Gene and Its Association with Hypertension and Stroke: An Updated Meta-Analysis

et al. 2013

View full text Add to dashboard Cite

ObjectiveSeveral epidemiological studies have evaluated the association between the GNB3 C825T polymorphism and hypertension or stroke. The results of these studies were inconsistent; therefore, we performed a meta-analysis to clarify these discrepancies.MethodsWe systematically searched the PubMed, Embase, Web of Science, CNKI, and CBM databases, and manually searched reference lists of relevant papers, meeting abstracts, and relevant journals. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for dominant, recessive, and allelic models. A fixed or random effects model was separately adopted depending on study heterogeneity. Subgroup and sensitivity analyses were performed to detect study heterogeneity and examine result stability, respectively. Publication bias was tested using funnel plots, the Egger's regression test, and Begg's test.ResultsWe screened 66 studies regarding hypertension and eight concerning stroke. A combined analysis showed that only the allelic model found a marginal association with hypertension (OR = 1.07, 95% CI = 1.01–1.13) and female gender (OR = 1.11, 95% CI = 0.99–1.24). However, no comparison models found an association with stroke (allelic model: OR = 1.11, 95% CI = 0.94–1.32; dominant model: OR = 1.16, 95% CI = 0.92–1.48; and recessive model: OR = 1.05, 95% CI = 0.97–1.14). Sensitivity analysis suggested that all models did not yield a relationship to hypertension or stroke among Asians. Besides, there was a lack of statistical association with hypertension in Caucasians, which maybe due to a small sample size. When we restricted the included studies to normal populations according to the Hardy–Weinberg equilibrium, no association was found.ConclusionsThere was no evidence indicating that the 825T allele or TT genotype was associated with hypertension or stroke in Asians or hypertension in Caucasians. However, further studies regarding Africans and other ethnicities are needed to identify further correlations.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The C825T Polymorphism of the G-Protein β3 Subunit Gene and Its Association with Hypertension and Stroke: An Updated Meta-Analysis

et al. 2013

View full text Add to dashboard Cite

show abstract

“…While these three polymorphisms were associated with obesity, no association with essential arterial hypertension was detected [ 37 , 38 ]. Another single-nucleotide polymorphism of GNB3 , the rs2301339, was linked to the young-onset hypertension in the Chinese population considering 992 young-onset hypertensive cases and 992 matched controls [ 39 ]. Furthermore, increased fasting plasma glucose levels were detected in Japanese patients suffering from diabetes mellitus type II and having the rs2301339 polymorphism of GNB3 [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

GNB3 c.825C>T (rs5443) Polymorphism and Risk of Acute Cardiovascular Events after Renal Allograft Transplant

Peitz

Möhlendick

Siffert

et al. 2022

IJMS

View full text Add to dashboard Cite

The c.825C>T single-nucleotide polymorphism (rs5443) of the guanine nucleotide-binding protein subunit β3 (GNB3) results in increased intracellular signal transduction via G-proteins. The present study investigated the effect of the GNB3 c.825C>T polymorphism on cardiovascular events among renal allograft recipients posttransplant. Our retrospective study involved 436 renal allograft recipients who were followed up for up to 8 years after transplant. The GNB3 c.825C>T polymorphism was detected with restriction fragment length polymorphism (RFLP) polymerase chain reaction (PCR). The GNB3 TT genotype was detected in 43 (10%) of 436 recipients. Death due to an acute cardiovascular event occurred more frequently among recipients with the TT genotype (4 [9%]) than among those with the CC/CT genotypes (7 [2%]; p = 0.003). The rates of myocardial infarction (MI)–free survival (p = 0.003) and acute peripheral artery occlusive disease (PAOD)–free survival (p = 0.004) were significantly lower among T-homozygous patients. A multivariate analysis showed that homozygous GNB3 c.825C>T polymorphism exerted only a mild effect for the occurrence of myocardial infarction (relative risk, 2.2; p = 0.065) or acute PAOD (relative risk, 2.4; p = 0.05) after renal transplant. Our results suggest that the homozygous GNB3 T allele exerts noticeable effects on the risk of MI and acute PAOD only in the presence of additional nonheritable risk factors.

show abstract

“…These inconsistent results were explained in part by population stratification, race differences, selection bias, genotyping errors, and other factors. In fact, numerous gene variants have been reported to be associated with common diseases, but few have been replicated [40]–[42]. Lack of replication has long been a big challenge in genetic association study.…”

Section: Discussionmentioning

confidence: 99%

Association Analysis of Polymorphisms in ROCK2 with Cardiovascular Disease in a Chinese Population

et al. 2013

View full text Add to dashboard Cite

BackgroundRho-kinase (ROCK) has been shown to play an important role in cardiovascular disease such as coronary artery disease (CAD) and hypertension. Recently, common variants of ROCK2 have been reported to influence blood pressure, but the relationship between common ROCK2 variants and cardiovascular disease has not been extensively studied in the Chinese population.MethodsTo derive a more precise estimation of their relationship, we screened for the common variants by direct sequencing of all exons of ROCK2, and then we performed genetic association analyses in a CAD case–control study, including a total of 1344 cases and 1267 ethnically and geographically matched controls.ResultsUnconditional logistic regression showed that no significant association between common variants in the coding region of ROCK2 and CAD was observed in our study (for rs978906, OR = 0.92, 95% CI 0.72–1.20 and P = 0.63; for rs2230774, OR = 0.90, 95% CI 0.70–1.16 and P = 0.47; for rs56304104, OR = 0.97, 95% CI 0.70–1.31 and P = 0.83; respectively).ConclusionsThe relationship between the ROCK2 polymorphisms and cardiovascular disease risk cannot be entirely discounted and warrants further evaluation in a large population.

show abstract

A Two-Stage Matched Case–Control Study on Multiple Hypertensive Candidate Genes in Han Chinese

Cited by 5 publications

References 38 publications

The C825T Polymorphism of the G-Protein β3 Subunit Gene and Its Association with Hypertension and Stroke: An Updated Meta-Analysis

The C825T Polymorphism of the G-Protein β3 Subunit Gene and Its Association with Hypertension and Stroke: An Updated Meta-Analysis

GNB3 c.825C>T (rs5443) Polymorphism and Risk of Acute Cardiovascular Events after Renal Allograft Transplant

Association Analysis of Polymorphisms in ROCK2 with Cardiovascular Disease in a Chinese Population

Contact Info

Product

Resources

About